Invited perspectives on hypofractionated stereotactic radiosurgery

2016 ◽  
pp. 1-8
Keyword(s):  
Stereotactic Radiosurgery ◽  
Hypofractionated Stereotactic Radiosurgery

scholarly journals Cyberknife® hypofractionated stereotactic radiosurgery (CK-hSRS) as salvage treatment for brain metastases

2021 ◽  
Author(s):  
Sergej Telentschak ◽  
Daniel Ruess ◽  
Stefan Grau ◽  
Roland Goldbrunner ◽  
Niklas von Spreckelsen ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Poor Prognosis ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Salvage Treatment ◽  
Treatment Modalities ◽  
Large Tumor ◽  
Fractionated Radiotherapy ◽  
Hypofractionated Stereotactic Radiosurgery

Abstract Purpose The introduction of hypofractionated stereotactic radiosurgery (hSRS) extended the treatment modalities beyond the well-established single-fraction stereotactic radiosurgery and fractionated radiotherapy. Here, we report the efficacy and side effects of hSRS using Cyberknife® (CK-hSRS) for the treatment of patients with critical brain metastases (BM) and a very poor prognosis. We discuss our experience in light of current literature. Methods All patients who underwent CK-hSRS over 3 years were retrospectively included. We applied a surface dose of 27 Gy in 3 fractions. Rates of local control (LC), systemic progression-free survival (PFS), and overall survival (OS) were estimated using Kaplan–Meier method. Treatment-related complications were rated using the Common Terminology Criteria for Adverse Events (CTCAE). Results We analyzed 34 patients with 75 BM. 53% of the patients had a large tumor, tumor location was eloquent in 32%, and deep seated in 15%. 36% of tumors were recurrent after previous irradiation. The median Karnofsky Performance Status was 65%. The actuarial rates of LC at 3, 6, and 12 months were 98%, 98%, and 78.6%, respectively. Three, 6, and 12 months PFS was 38%, 32%, and 15%, and OS was 65%, 47%, and 28%, respectively. Median OS was significantly associated with higher KPS, which was the only significant factor for survival. Complications CTCAE grade 1–3 were observed in 12%. Conclusion Our radiation schedule showed a reasonable treatment effectiveness and tolerance. Representing an optimal salvage treatment for critical BM in patients with a very poor prognosis and clinical performance state, CK-hSRS may close the gap between surgery, stereotactic radiosurgery, conventional radiotherapy, and palliative care.

The Outcome of Hypofractionated Stereotactic Radiosurgery for Large Vestibular Schwannomas

2016 ◽  
Vol 93 ◽  
pp. 398-409 ◽  
Author(s):  
Mario Teo ◽  
Michael Zhang ◽  
Amy Li ◽  
Patricia A. Thompson ◽  
Armine T. Tayag ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Vestibular Schwannomas ◽  
Hypofractionated Stereotactic Radiosurgery

Experience with hypofractionated stereotactic radiosurgery in a series of patients with skull base tumors

2018 ◽  
Vol 7 (4) ◽  
pp. 307-315
Author(s):  
Diego Aldo Hernández ◽  
Juan M. Zaloff Dakoff ◽  
Cynthia Auad ◽  
Víctor Eduardo Derechinsky ◽  
Roberto Rosler ◽  
...  
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Skull Base Tumors ◽  
Hypofractionated Stereotactic Radiosurgery

Assessment of the alpha/beta ratio of the optic pathway to adjust hypofractionated stereotactic radiosurgery regimens for perioptic lesions

2019 ◽  
Vol 8 (3) ◽  
pp. 279-289
Author(s):  
Herwin Speckter ◽  
Jairo Santana ◽  
Isidro Miches ◽  
Giancarlo Hernandez ◽  
Jose Bido ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Optic Pathway ◽  
Alpha Beta ◽  
Hypofractionated Stereotactic Radiosurgery
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