Essential Oils, the Immune System, and Inammation

Aromatherapy ◽  
2015 ◽  
pp. 300-327
Keyword(s):  
Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Ghasemi Pirbalouti ◽  
E Pirali ◽  
G Pishkar ◽  
S Mohammadali Jalali ◽  
M Reyesi ◽  
...  

2019 ◽  
Author(s):  
Markus Rienth ◽  
Julien Crovadore ◽  
Sana Ghaffari ◽  
François Lefort

AbstractThe reduction of synthetic fungicides in agriculture a major challenge in maintaining sustainable production, protecting the environment and consumers’ health. Downy mildew caused by the oomycete Plasmopora viticola is the major pathogen in viticulture worldwide and responsible for up to 60% of pesticide treatments. Alternatives to reduce fungicides are thus utterly needed to ensure sustainable vineyard-ecosystems, consumer health and public acceptance. Essential oils (EOs) are amongst the most promising natural plant protection alternatives and have shown their antibacterial, antiviral and antifungal properties on several agricultural crops. However, the efficiency of EOs highly depends on timing, application method and the molecular interactions between the host, the pathogen and EO. Despite proven EO efficiency, the underlying processes are still not understood and remain a black box. The objectives of the present study were: a) to evaluate whether a continuous fumigation of a particular EO can control downy mildew in order to circumvent the drawbacks of direct application, b) to decipher molecular mechanisms that could be triggered in the host and the pathogen by EO application and c) to try to differentiate whether essential oils directly repress the oomycete or act as plant resistance primers.A custom-made climatic chamber was used for a continuous fumigation of potted vines with different EOs during long-term experiments. The grapevine (Vitis vinifera) cv Chasselas was chosen in reason of its high susceptibility to Plasmopara viticola. Grapevine cuttings were infected with P. viticola. and subsequently exposed to continuous fumigation of different EOs at different concentrations, during 2 application time spans (24 hours and 10 days). Experiments were stopped when infection symptoms were clearly observed on the leaves of the control plants. Plant physiology (photosynthesis and growth rate parameters) were recorded and leaves were sampled at different time points for subsequent RNA extraction and transcriptomics analysis. Strikingly, the Oregano vulgare essential oil vapour treatment during 24h post-infection proved to be sufficient to reduce downy mildew development by 95%. Total RNA was extracted from leaves of 24h and 10d treatments and used for whole transcriptome shotgun sequencing (RNA-seq). Sequenced reads were then mapped onto the V. vinifera and P. viticola genomes. Less than 1% of reads could be mapped onto the P. viticola genome from treated samples, whereas up to 30 % reads from the controls mapped onto the P. viticola genome, thereby confirming the visual observation of P. viticola absence in the treated plants. On average, 80 % of reads could be mapped onto the V. vinifera genome for differential expression analysis, which yielded 4800 modulated genes. Transcriptomic data clearly showed that the treatment triggered the plant’s innate immune system with genes involved in salicylic, jasmonic acid and ethylene synthesis and signaling, activating Pathogenenesis-Related-proteins as well as phytoalexin synthesis.These results elucidate EO-host-pathogen interactions for the first time and indicate that the antifungal efficiency of EO is mainly due to the triggering of resistance pathways inside the host plants. This is of major importance for the production and research on biopesticides, plant stimulation products and for resistance-breeding strategiesAuthor SummaryThe reduction of synthetic plant protection products is a major concern of modern agriculture. The oomycetePlasmopora viticolawhich causes downy mildew in grapevine is amongst the most important grapevine pests and responsible for the dispersion of huge amounts of pesticides in vineyards. Among the evaluated alternatives to reduce or replace synthetic pesticides, plant volatile compounds could represent a sustainable solution. Some plant essential oils (EOs) have already shown antifungal capacities. However, their application is often difficult in terms of the right timing of treatment, degradation, bad rainfastness, mixability and phytotoxicity.The aim of the present work was to investigate whether the vapour phase, applied by a continuous fumigation of different EOs, might inhibit the development of downy mildew on grapevine, and in case of proven efficiency, to study the induced transcriptomic changes by RNA-sequencing in an attempt to elucidate the underlaying molecular interactions. Our results showed that the vapour phases ofO. vulgareandT. vulgariswere highly efficient against the pathogen. The study of differentially expressed genes indicated that the EO vapour triggered the main mechanisms of the plant’s innate immune system such as PTI (Pattern-Triggered Immunity) and ETI (Effector Triggered immunity).For the first time these results highlight the effects of EOs vapour on plant genes expression, which is very valuable information for the development of new natural plant protection products, as well as for breeding disease resistant cultivars.


2022 ◽  
Vol 146 ◽  
pp. 112514
Author(s):  
Mansi Sharma ◽  
Kamaljit Grewal ◽  
Rupali Jandrotia ◽  
Daizy Rani Batish ◽  
Harminder Pal Singh ◽  
...  

2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Крикорова ◽  
S. Krikorova ◽  
Бобкова ◽  
A. Bobkova ◽  
Деревнина ◽  
...  

Purpose of this research is to study the effects of a essential oils mixture applications on the dynamics of the correlation of the immune and hormonal status, and the treatment efficiency of osteoarthritis. Materials and methods. 30 women with OA were treated with applications of 5% mix EO: lavender, gin-ger, peppermint, rosemary, pine, clove, nutmeg, eucalyptus, thyme, anise. Dynamics of the correlation of immu-nological status indicators: total number of cells; absolute and % of number of total lympho-cytes,CD3,CD4+,CD8+, To cells, indicators immune-regulatory index CD4+/CD8+, absolute and % indicators CD19, IgG, IgA, IgM was studied. Dynamics of the correlation of endocrine system: STH, PL, cortisol, , TTH, fT4, fT3, PTH, CT, osteocalcin, LH, FSH, ED and TS, DHEA, AS, PG, INS, С-P, index HOMA-IR was also studied. Results. Before treatment - immunodeficiency CD3, CD4, increase CD8+ (cytotoxic cells), low level in-dicators index CD4+ /CD8+ were revealed. Low level indicators CD3, CD4 according to the correlation analysis resulted in reducing the formation of IgM, IgG, IgA was noted. Before treatment low levels of sex steroids ED, TS were revealed. The main hormones support the immune system before treatment, were ED, PTH, CT. After treatment – there were increase in CD3, CD4-cells, index indicators CD4+ /CD8+, reduced CD8, a statistically significant increase in TS (p<0.05), reducing INS and glucose (p<0.05), index HOMA-IR (p<0.05).The main hormones support the immune system after treatment began INS (p<0.05) and thyroid hormones, PTH. The dynamics of the correlation of the immune and hormonal status is associated with a decrease in pain, improved joint function, according to index Lekena (p<0.05).


2021 ◽  
Vol 914 (1) ◽  
pp. 012073
Author(s):  
A Aswandi ◽  
C R Kholibrina

Abstract The global pandemic Covid-19 has become a worldwide challenge. Many continuous efforts have been conducted to prevent and combat the diseases that attack human respiratory system. This situation encourages the exploration of potential herbal remedies involving essential oils from forest to boost human immune system. The objectives of study were to explore the traditional application of forest’s essential oils and to identify the phytochemical content of herbal medicines in respiratory and cardiovascular treatments in Northern Sumatra. In-depth interviews were conducted with 27 local people who applied essential oils in their traditional remedies in Karo and Toba, North Sumatra; and Singkil and South Aceh during 2020. The essential oils benefits in Covid-19 treatment were identified by inhaling application to seven positive suspects. The study also reviewed previous findings according the phytochemical content of forest essential oils identified. The study identified twelve forest’s essential oils applied in respiratory and cardiovascular treatments, including Cinnamomum zeylanicum, Dryobalanops aromatica, Eucalyptus sp., Litsea cubeba, Melaleuca cajuput, Myristica fragrans, Styrax sumatrana, Syzygium aromaticum, and. Zanthoxylum acanthopodium. The oils were distilled from plant part such as flowers, leaves, fruits, seeds, and barks or extracted from resin. Several phytochemicals with medicinal properties were identified including 1.8-cineole, apinene, camphene, eugenol, limonene, linalool, and p-cymene. In aromatherapeutic practices by both inhalation and massage, the phytochemical content gives relaxing effects and improve the respiratory and cardiovascular system. The results also show that inhaling the essential oils also helps Covid-19 patients relieve their breathing, therefore prospective for respiratory treatment. The high stress conditions faced by patients were also reduced by inhaling aromatherapy. The study re-discovered the essential oils benefits for various conditions such as headaches and hypertension, while having high potential as an expectorant and immune system booster.


1963 ◽  
Vol 35 (5) ◽  
pp. 5-0 ◽  
Author(s):  
James A. Rogers
Keyword(s):  

1980 ◽  
Vol 19 (5) ◽  
pp. 1537-1539 ◽  
Author(s):  
W Campbell
Keyword(s):  

2007 ◽  
Vol 38 (3) ◽  
pp. 25
Author(s):  
MARY ANN MOON
Keyword(s):  

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