scholarly journals Infectious Diseases of the Brain

2016 ◽  
pp. 631-680
Keyword(s):  
Infectious Diseases ◽  
The Brain

scholarly journals Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Gwang-Ho Kim ◽  
Sun Shin Yi
Keyword(s):  
Infectious Diseases ◽  
Rapid Assessment ◽  
Foot And Mouth Disease ◽  
Vaccine Safety ◽  
International Standards ◽  
First Century ◽  
Safety Testing ◽  
Live Vaccines ◽  
Safety Test ◽  
The Brain

AbstractIn the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very prevalent, causing treat harm to humans and animals in aspect of public health, and economical issues. The critical problem is that newly-reported infectious diseases that humans firstly experience are expected to continue to emerge, and these diseases will be spreading out rapidly. Therefore, rapid and safe supplies of effective vaccines are most pivotal to prevent the rapid prevalent of new infection, but international standards or assessing protocol the safety of urgent vaccines are not established well. In our previous study, since we established a module to assess the brain safety of urgent vaccines, therefore, it is necessary to verify that this established module for assessing brain safety could work effectively in commercially available two vaccines (one killed- and on live-vaccines). We compared the results of Evans blue (EB) assay and qPCR analysis by injection of two kinds of vaccines, PBS and Lipopolysaccharide (LPS) under the condition of the module previously reported. We confirmed that the brain safety test module for urgent vaccine we established is very reproducible. Therefore, it is believed that this vaccine safety testing method can be used to validate brain safety when prompt supply of a newly developed vaccines is needed.

scholarly journals A IS FOR AMYLOID

2020 ◽  
pp. 1-2
Author(s):  
D.J. Selkoe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Infectious Diseases ◽  
Task Force ◽  
Modern Medicine ◽  
Disease Modifying ◽  
The Brain ◽  
The Eu

In the age of COVID-19, we are reminded that despite the enormous strides modern medicine has made against acute infectious pathogens, we can still be overwhelmed. And in the field of chronic non-infectious diseases of the brain, we, too, have been traveling a long and unpredictable road. For years, there has been a sense of pessimism about the halting march toward disease-modifying treatments for Alzheimer’s disease. But recent events may have begun to part the clouds. In this issue of JPAD, Aisen et al. (1), representing the EU/US CTAD 2019 Task Force, provide a thoughtful perspective on progress in certain anti-amyloid trials and the resultant lessons for our next steps toward success.

Ultrasound neuroimaging as a technology for screening diagnostics of the central nervous system pathology in children

2020 ◽  
Vol 18 (6) ◽  
pp. 83-96
Author(s):  
Yu. P. VASILYEVA ◽  
◽  
N. V. SKRIPCHENKO ◽  
A. V. KLIMKIN ◽  
A. A. VILNITS ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Spinal Cord ◽  
Infectious Diseases ◽  
Ultrasound Screening ◽  
Pathological Changes ◽  
Prophylactic Examination ◽  
Primary Diagnostics ◽  
The Central Nervous System ◽  
Screening Diagnostics ◽  
The Brain

The article presents the results of analysis of 3466 examinations (2012–2018), obtained from screening of brain (neurosonography) and spinal cord (spinal ultrasonography) in children during an outpatient prophylactic examination (n = 593) and in the infectious hospital as a primary structural diagnostics of patients with a suspected infectious disease (n = 2873). In prophylactic screening, over a half of children (67%) demonstrated pathological changes in brain, of which 4,1% patients had symptomless course of structural deficit, which may cause unfavorable consequences. Spinal ultrasonography during an outpatient screening showed ultrasound symptoms of the spinal cord in 61% cases. When an infectious disease was suspected in the infectious hospital, neurosonography showed pathological changes in brain in 45% patients, and in 90% of cases the revealed disorders were not of infectious nature, but served as the ground for changing the therapeutic tactics, which determined the outcome of the main disease. The presented clinical cases substantiate the need for ultrasound screening of not only the brain but also the spinal cord at dispensarization of young children. The obtained results show the need to perform planned neurosonography at birth, at 1 and 3 months, at 1 year, further on indications stemming from previous examinations. Spinal ultrasonography should be performed to all children at the age of 1 month. The article also presents the experience of sonography screening in children with infectious diseases, which confirms the need to perform neurosonography during primary diagnostics in children of all ages with infectious diseases accompanied by general cerebral syndrome.

Relation of diseases of the nervous system to diseases of the upper respiratory tract

1927 ◽  
Vol 23 (4) ◽  
pp. 473-473
Author(s):  
M. F. Tsytovich
Keyword(s):  
Nervous System ◽  
Infectious Diseases ◽  
Respiratory Tract ◽  
Cranial Nerves ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Nutritional Disturbances ◽  
Almost All ◽  
The Brain

Noting that diseases of the cranial nervous system may result from 1) infection, 2) nutritional disturbances, and 3) disturbances of normal stimuli (reflexes), the author points out that a huge percentage of infectious diseases of the brain and the meninges have their source in the nose and its appendage cavities. Almost all cranial nerves can also be infected from the nose and its appendages.

scholarly journals Renal Hydatid Cyst in a 50-year-old woman: A Case Report

2019 ◽  
Author(s):  
Khadijeh Abdal ◽  
Mohammad Reza HafeziAhmadi
Keyword(s):  
Case Report ◽  
Infectious Diseases ◽  
Hydatid Cyst ◽  
Rare Occurrence ◽  
The Brain

Introduction: Hydatidosis (hydatid cyst) is one of the most common infectious diseases between humans and animals that it is created by parasite (tapeworm) the echinococcusgranulosus larvae, which randomly infects an individual to one or more cysts. The hydatid cyst can affect all organs. The most common sites of involvement is liver and lung and rarely other organs, such as the kidneys, the brain, the heart, the bone and the spleen, can also be involved. Due to the rare occurrence of renal hydatid cyst in this article, we report a 50 year old patient with renal hydatid cyst

scholarly journals Infectious Diseases of the Brain

2005 ◽  
Vol 13 (1) ◽  
pp. A4.0.1-A4.0.1
Author(s):  
Andrew E. Auber ◽  
Clifford Belden
Keyword(s):  
Infectious Diseases ◽  
The Brain
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