Applied Chemistry Research Notes

2006 ◽  
Vol 78 (5) ◽  
pp. iv
Author(s):  
Chunli Bai

"Creativity is the soul of a nation and an inexhaustible source of a country's prosperity." Original innovation, as the major source of new technologies, will not only bring about technological breakthroughs, but give rise to new industries and new economic structures, offering unlimited opportunities for later starters to overtake the frontrunners. "Innovation in Chemistry" is the specific theme for the 40th International Union of Pure and Applied Chemistry (IUPAC) Congress, which was held on 14-19 August 2005 in Beijing, China. The Congress provided an excellent forum for presenting the latest innovative achievements in the chemical sciences and in the practice of chemistry.A total of 1083 participants from 64 countries attended the Congress. With 412 of the participants from mainland China and 556 from other countries and regions, the Congress helped to build a bridge between Chinese chemists and the world, encouraging cooperation and excellence in fundamental research and industrializations.The high-scientific value of the Congress was evident in the plenary lectures, which were delivered by eight distinguished chemists, including three Nobel Laureates and one Einstein Award Winner. A total of 1145 papers and 622 posters were presented in the eight sessions of the Congress: (1) Environmental Chemistry and Green Chemistry; (2) Chemistry in the Life Sciences and Chemical Biology; (3) Materials Chemistry, Supermolecular Chemistry, and Nanochemistry; (4) Information Technology in Chemistry and Computational Chemistry; (5) Innovation in Physical Chemistry and Biophysical Chemistry: Research Methods and Techniques; (6) Innovation in Methodology, Technique, and Instrumentation and Analytical Chemistry; (7) Innovation in Chemical Education and Teaching Methods; (8) Innovation in the Chemical and Petrochemical Industries and "Responsible Care" for Society.Fourteen papers selected from the plenary and invited lectures from the 40th IUPAC Congress are published in this special issue of Pure and Applied Chemistry (PAC), which cover a spectrum from theoretical chemistry to chemical engineering, from micro/nanoscale studies to industrial-scale process/equipment evaluations. The review on the study of single molecules and their assembly provides a comprehensive, up-to-date summary of the field based on the fundamental research; much of the information presented falls within the special expertise of the group. The paper on the superheavy element describes the latest developments in a field that has shown higher activity in recent years as the predicted "island of stability" comes within the reach of the available hardware. This area is always of special interest to international scientists owing to the special synthesis techniques for superheavy elements employed by the Dubna group. Green chemistry is becoming a characteristic area in China that plays a significant role in motivating the development of new synthetic techniques, such as cross-dehydrogenative coupling. Other papers in this issue address a variety of topics from novel instrumentation for electrochemical impedance spectroscopy to synthesis of oxide nanomaterials; from catalysts to waste water treatment. These papers give a snapshot of the research reported at the 40th IUPAC Congress. I sincerely hope that this special issue of PAC brings some fresh ideas, novel concepts, and useful data to the readers.The International Organizing Committee contributed to the shaping of an important area of emerging science and technology. Thanks and appreciations are due to the Local Organizing Committee for the efficiency and excellence of the local arrangements and for the gracious hospitality. I am grateful to those who contributed their latest research work to this issue, and the support from Dr. John W. Jost, IUPAC Executive Director.Chunli BaiPresident of the 40th IUPAC Congress,President of the Chinese Chemical Society,and Executive Vice President of the Chinese Academy of Sciences


Author(s):  
J. Kulik ◽  
Y. Lifshitz ◽  
G.D. Lempert ◽  
S. Rotter ◽  
J.W. Rabalais ◽  
...  

Carbon thin films with diamond-like properties have generated significant interest in condensed matter science in recent years. Their extreme hardness combined with insulating electronic characteristics and high thermal conductivity make them attractive for a variety of uses including abrasion resistant coatings and applications in electronic devices. Understanding the growth and structure of such films is therefore of technological interest as well as a goal of basic physics and chemistry research. Recent investigations have demonstrated the usefulness of energetic ion beam deposition in the preparation of such films. We have begun an electron microscopy investigation into the microstructure and electron energy loss spectra of diamond like carbon thin films prepared by energetic ion beam deposition.The carbon films were deposited using the MEIRA ion beam facility at the Soreq Nuclear Research Center in Yavne, Israel. Mass selected C+ beams in the range 50 to 300 eV were directed onto Si {100} which had been etched with HF prior to deposition.


2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>


2019 ◽  
Vol 16 (3) ◽  
pp. 290-306
Author(s):  
Rina Das ◽  
Gyati S. Asthana ◽  
Krishan A. Suri ◽  
Dinesh Mehta ◽  
Abhay Asthana

Tuberculosis (TB) is a global health disaster and is a wide-reaching hitch. The improper use of antibiotics in chemotherapy of TB patients led to the current problem of tuberculosis therapy which gives rise to Multi-Drug Resistant (MDR) strains. Nitrogen heterocycles including azole compounds are an important class of therapeutic agent with electron-rich property. Azole-based derivatives easily bind with the enzymes and receptors in organisms through noncovalent interactions, thereby possessing various applications in medicinal chemistry. Research on azoles derivatives have been expansively carried out and have become one of the extremely active area in recent years and the progress is quite rapid. A genuine attempt to review chemistry of azoles and to describe various azole-based compounds synthesized in the last two decades having promising antitubercular potential is described in the present article. It is hopeful that azole compounds may continue to serve as an important direction for the exploitation of azole-based antitubercular drugs with better curative effect, lower toxicity, less side effects, especially fewer resistances and so on.


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