Experimental Models of Traumatic Brain Injury: Clinical Relevance and Shortcomings

2016 ◽  
pp. 118-183
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Relevance ◽  
Experimental Models

scholarly journals Large animal models of stroke and traumatic brain injury as translational tools

2018 ◽  
Vol 315 (2) ◽  
pp. R165-R190 ◽  
Author(s):  
Annabel J. Sorby-Adams ◽  
Robert Vink ◽  
Renée J. Turner
Keyword(s):  
Traumatic Brain Injury ◽  
Ischemic Stroke ◽  
Brain Injury ◽  
Animal Models ◽  
Animal Species ◽  
Experimental Models ◽  
Clinical Translation ◽  
Large Animal ◽  
Large Animal Models ◽  
Significant Burden

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide. Studies in animal models have greatly enhanced our understanding of the complex pathophysiology that underlies TBI and stroke and enabled the preclinical screening of over 1,000 novel therapeutic agents. Despite this, the translation of novel therapeutics from experimental models to clinical therapies has been extremely poor. One potential explanation for this poor clinical translation is the choice of experimental model, given that the majority of preclinical TBI and ischemic stroke studies have been conducted in small animals, such as rodents, which have small lissencephalic brains. However, the use of large animal species such as nonhuman primates, sheep, and pigs, which have large gyrencephalic human-like brains, may provide an avenue to improve clinical translation due to similarities in neuroanatomical structure when compared with widely adopted rodent models. This purpose of this review is to provide an overview of large animal models of TBI and ischemic stroke, including the surgical considerations, key benefits, and limitations of each approach.

scholarly journals Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury

2020 ◽  
Vol 37 (22) ◽  
pp. 2381-2400 ◽  
Author(s):  
Sandy R. Shultz ◽  
Stuart J. McDonald ◽  
Frances Corrigan ◽  
Bridgette D. Semple ◽  
Sabrina Salberg ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Animal Models ◽  
Clinical Relevance

Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models

2010 ◽  
Vol 13 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Peter-Georg Hoffmeister ◽  
Cornelius K. Donat ◽  
Martin U. Schuhmann ◽  
Cornelia Voigt ◽  
Bernd Walter ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Nicotinic Receptor ◽  
Experimental Models ◽  
Receptor Density

scholarly journals The pathophysiology of repetitive concussive traumatic brain injury in experimental models; new developments and open questions

2015 ◽  
Vol 66 ◽  
pp. 91-98 ◽  
Author(s):  
David L. Brody ◽  
Joseph Benetatos ◽  
Rachel E. Bennett ◽  
Kristen C. Klemenhagen ◽  
Christine L. Mac Donald
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Experimental Models ◽  
New Developments ◽  
Open Questions
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