Carbonyl Chemistry in a Multistep Synthesis

2015 ◽  
pp. 84-95
Keyword(s):  
Multistep Synthesis

scholarly journals Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow**

2021 ◽  
Author(s):  
Peter Sagmeister ◽  
René Lebl ◽  
Ismael Castillo ◽  
Jakob Rehrl ◽  
Julia Kruisz ◽  
...  
Keyword(s):  
Real Time ◽  
Continuous Flow ◽  
Time Process ◽  
Process Analytics ◽  
Multistep Synthesis

scholarly journals Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow**

2021 ◽  
Author(s):  
Peter Sagmeister ◽  
René Lebl ◽  
Ismael Castillo ◽  
Jakob Rehrl ◽  
Julia Kruisz ◽  
...  
Keyword(s):  
Real Time ◽  
Continuous Flow ◽  
Time Process ◽  
Process Analytics ◽  
Multistep Synthesis

scholarly journals A Bifunctional Metal/Acid Catalyst for One-pot Multistep Synthesis of Pharmaceuticals

2020 ◽  
Vol 60 (4) ◽  
pp. 499-507
Author(s):  
Maria Victoria Lopez-Prado ◽  
María J. Sabater ◽  
Avelino Corma
Keyword(s):  
Acid Catalyst ◽  
One Pot ◽  
Multistep Synthesis

scholarly journals Integrated flow processing — challenges in continuous multistep synthesis

2017 ◽  
Vol 7 (3–4) ◽  
pp. 129-136 ◽  
Author(s):  
Bartholomäus Pieber ◽  
Kerry Gilmore ◽  
Peter H. Seeberger
Keyword(s):  
Multistep Synthesis

scholarly journals Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

2017 ◽  
Vol 13 ◽  
pp. 960-987 ◽  
Author(s):  
Chinmay A Shukla ◽  
Amol A Kulkarni
Keyword(s):  
Industrial Process ◽  
Pilot Scale ◽  
Laboratory Scale ◽  
Flow Synthesis ◽  
Multistep Synthesis ◽  
Synthesis Strategy ◽  
Line Separation ◽  
Synthesis Approach ◽  
Scale Of Operation

The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature.

14 Electrochemistry in Natural Product Synthesis

2022 ◽  
Author(s):  
K. Lam ◽  
M. C. Leech ◽  
A. J. J. Lennox
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Redox Reactions ◽  
Natural Product Synthesis ◽  
Reaction Type ◽  
Multistep Synthesis ◽  
Reaction Solution ◽  
Electrochemical Redox ◽  
Synthetic Methodologies ◽  
Unique Ability

The multistep synthesis of natural products has historically served as a useful and informative platform for showcasing the best, state-of-the-art synthetic methodologies and technologies. Over the last several decades, electrochemistry has proved itself to be a useful tool for conducting redox reactions. This is primarily due to its unique ability to selectively apply any oxidizing or reducing potential to a sufficiently conductive reaction solution. Electrochemical redox reactions are readily scaled and can be more sustainable than competing strategies based on conventional redox reagents. In this chapter, we summarize the examples where electrochemistry has been used in the synthesis of natural products. The chapter is organized by the reaction type of the electrochemical step and covers both oxidative and reductive reaction modes.

scholarly journals Cu(II) and magnetite nanoparticles decorated melamine-functionalized chitosan: A synergistic multifunctional catalyst for sustainable cascade oxidation of benzyl alcohols/Knoevenagel condensation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zahra Alirezvani ◽  
Mohammad G. Dekamin ◽  
Ehsan Valiey
Keyword(s):  
Catalytic Activity ◽  
Knoevenagel Condensation ◽  
Ambient Pressure ◽  
Reaction Medium ◽  
Environmentally Benign ◽  
One Pot ◽  
Benzyl Alcohols ◽  
External Magnet ◽  
Multistep Synthesis ◽  
Multifunctional Catalyst

AbstractThe uniform decoration of Cu(II) species and magnetic nanoparticles on the melamine-functionalized chitosan afforded a new supramolecular biopolymeric nanocomposite (Cs-Pr-Me-Cu(II)-Fe3O4). The morphology, structure, and catalytic activity of the Cs-Pr-Me-Cu(II)-Fe3O4 nanocomposite have been systematically investigated. It was found that Cs-Pr-Me-Cu(II)-Fe3O4 nanocomposite can smoothly promote environmentally benign oxidation of different benzyl alcohol derivatives by tert-butyl hydroperoxide (TBHP) to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile, as a multifunctional catalyst. Interestingly, Fe3O4 nanoparticles enhance the catalytic activity of Cu(II) species. The corresponding benzylidenemalononitriles were formed in high to excellent yields at ambient pressure and temperature. The heterogeneous Cs-Pr-Me-Cu(II)-Fe3O4 catalyst was also very stable with almost no leaching of the Cu(II) species into the reaction medium and could be easily recovered by an external magnet. The recycled Cs-Pr-Me-Cu(II)-Fe3O4 was reused at least four times with slight loss of its activity. This is a successful example of the combination of chemo- and bio-drived materials catalysis for mimicing biocatalysis as well as sustainable and one pot multistep synthesis.

scholarly journals Bio-Based Chemicals from Renewable Biomass for Integrated Biorefineries

Energies ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 233 ◽  
Author(s):  
Kirtika Kohli ◽  
Ravindra Prajapati ◽  
Brajendra Sharma
Keyword(s):  
Large Scale ◽  
Large Fraction ◽  
Single Step ◽  
Industrial Chemicals ◽  
Renewable Biomass ◽  
Platform Chemicals ◽  
Multistep Synthesis ◽  
Renewable Feedstock ◽  
Biomass Sugars ◽  
Conversion Technologies

The production of chemicals from biomass, a renewable feedstock, is highly desirable in replacing petrochemicals to make biorefineries more economical. The best approach to compete with fossil-based refineries is the upgradation of biomass in integrated biorefineries. The integrated biorefineries employed various biomass feedstocks and conversion technologies to produce biofuels and bio-based chemicals. Bio-based chemicals can help to replace a large fraction of industrial chemicals and materials from fossil resources. Biomass-derived chemicals, such as 5-hydroxymethylfurfural (5-HMF), levulinic acid, furfurals, sugar alcohols, lactic acid, succinic acid, and phenols, are considered platform chemicals. These platform chemicals can be further used for the production of a variety of important chemicals on an industrial scale. However, current industrial production relies on relatively old and inefficient strategies and low production yields, which have decreased their competitiveness with fossil-based alternatives. The aim of the presented review is to provide a survey of past and current strategies used to achieve a sustainable conversion of biomass to platform chemicals. This review provides an overview of the chemicals obtained, based on the major components of lignocellulosic biomass, sugars, and lignin. First, important platform chemicals derived from the catalytic conversion of biomass were outlined. Later, the targeted chemicals that can be potentially manufactured from the starting or platform materials were discussed in detail. Despite significant advances, however, low yields, complex multistep synthesis processes, difficulties in purification, high costs, and the deactivation of catalysts are still hurdles for large-scale competitive biorefineries. These challenges could be overcome by single-step catalytic conversions using highly efficient and selective catalysts and exploring purification and separation technologies.

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