Dissemination and adhesion of peritoneal cancer cells to the peritoneal wall

2015 ◽  
pp. 71-82
Author(s):  
Elly De Vlieghere ◽  
Marc Bracke ◽  
Laurine Verset ◽  
Pieter Demetter ◽  
Olivier De Wever
Keyword(s):  
Cancer Cells ◽  
Peritoneal Cancer ◽  
Peritoneal Wall

Abstract 1552: Resveratrol increases sensitivity of human peritoneal cancer cells to macrophage-mediated cytolysis

2012 ◽  
Author(s):  
Donald P. Braun ◽  
Adriana Rosales ◽  
Komen Brown ◽  
Timothy C. Birdsall ◽  
Edgar D. Staren ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Peritoneal Cancer

Abstract 1876: Oxidative metabolism by human peritoneal cancer cells stimulated with death ligands.

2013 ◽  
Author(s):  
Donald P. Braun ◽  
Derek M. Johnson ◽  
Adriana Rosales ◽  
C. Komen Brown
Keyword(s):  
Cancer Cells ◽  
Oxidative Metabolism ◽  
Peritoneal Cancer

scholarly journals Detection of Free Peritoneal Cancer Cells in Gastric Cancer Using Cancer-Specific Newcastle Disease Virus

2009 ◽  
Vol 14 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Joyce Wong ◽  
Allison Schulman ◽  
Kaitlyn Kelly ◽  
Dmitriy Zamarin ◽  
Peter Palese ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Newcastle Disease Virus ◽  
Cancer Cells ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Peritoneal Cancer

Surgery-Induced Peritoneal Cancer Cells in Patients Who Have Undergone Curative Gastrectomy for Gastric Cancer

2014 ◽  
Vol 21 (6) ◽  
pp. 1991-1997 ◽  
Author(s):  
Katsushi Takebayashi ◽  
Satoshi Murata ◽  
Hiroshi Yamamoto ◽  
Mitsuaki Ishida ◽  
Tsuyoshi Yamaguchi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Curative Gastrectomy ◽  
Peritoneal Cancer

1015 Enhancing Detection of Free Peritoneal Cancer Cells in Gastric Cancer Using Newcastle Disease Virus

2009 ◽  
Vol 136 (5) ◽  
pp. A-883
Author(s):  
Joyce Wong ◽  
Allison Schulman ◽  
Kaitlyn Kelly ◽  
Dmitriy Zamarin ◽  
Peter Palese ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Newcastle Disease Virus ◽  
Cancer Cells ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Peritoneal Cancer

scholarly journals Reprogramming of pro-tumor macrophages by hydroxychloroquine in an abdominally metastasized diffuse midline glioma

2021 ◽  
Author(s):  
Hendrik G Stunnenberg ◽  
Cristian Ruiz Moreno ◽  
Farid Keramati ◽  
Peter Brazda ◽  
Wout Megchelenbrink ◽  
...  
Keyword(s):  
Single Cell ◽  
Cancer Cells ◽  
Immune Cell ◽  
Cytotoxic T Cells ◽  
Suppressor Cells ◽  
Peritoneal Cancer ◽  
Inflammatory State ◽  
Therapeutic Decision Making ◽  
Inflammatory Macrophages ◽  
Diffuse Midline Glioma

Macrophage (Mφ) repolarization from a pro-tumor, immunosuppressive phenotype towards an anti-tumor, pro-inflammatory state represents a promising therapeutic strategy in patients with cancer1. Successful reprogramming of Mφ in a clinical setting has not been documented. Here, we traced the evolution at single-cell resolution of a diffuse midline glioma (DMG) with H3K27M mutation which metastasized in the abdomen after placing a ventriculoperitoneal (VP) shunt and exploited this information for therapeutic decision-making. The primary tumor showed a complex cellular and genomic landscape characterized by heterogeneous cancer cells and a tumor-supportive immune microenvironment. Upon metastasis, malignant cells populated the peritoneum and triggered a massive anti-inflammatory immune cell infiltration and expansion of myeloid-derived suppressor cells (MDSCs) in peripheral blood. Hydroxychloroquine adjuvant treatment started to overcome the immunosuppressive milieu, which resulted in a decrease in peritoneal cancer cells and pro-tumor innate immune cells. Importantly, an emergence of anti-tumor, pro-inflammatory macrophages and cytotoxic T-cells was observed, accompanied by the activation of monocytes in the blood. Our study advocates the employment of single-cell technologies to better understand and inspire therapeutic regimens in patients with cancer.

Abstract 1802: Genomic changes elicited by mitomycin C that confer increased sensitivity of peritoneal cancer cells to death ligands

2011 ◽  
Author(s):  
Donald P. Braun ◽  
Derek M. Johnson ◽  
C. Komen Brown ◽  
Adriana Rosales ◽  
David Berd ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mitomycin C ◽  
Peritoneal Cancer ◽  
Genomic Changes ◽  
Increased Sensitivity

Ultrastructural modification of cellular interactions in cancer tumor

1978 ◽  
Vol 36 (2) ◽  
pp. 318-319
Author(s):  
N. P. Dmitrieva
Keyword(s):  
Cancer Cells ◽  
Human Thyroid ◽  
Adjacent Cell ◽  
Main Role ◽  
Cellular Interactions ◽  
Electron Microscopic ◽  
Cancer Tumor ◽  
Normal Human ◽  
Characteristic Features

One of the most characteristic features of cancer cells is their ability to metastasia. It is suggested that the modifications of the structure and properties of cancer cells surfaces play the main role in this process. The present work was aimed at finding out what ultrastructural features apear in tumor in vivo which removal of individual cancer cells from the cell population can provide. For this purpose the cellular interactions in the normal human thyroid and cancer tumor of this gland electron microscopic were studied. The tissues were fixed in osmium tetroxide and were embedded in Araldite-Epon.In normal human thyroid the most common type of intercellular contacts was represented by simple junction formed by the parallelalignment of adjacent cell membranees leaving in between an intermembranes space 15-20 nm filled with electronlucid material (Fig. 1a). Sometimes in the basal part of cells dilatations of the intercellular space 40-50 nm wide were found (Fig. 1a). Here the cell surfaces may form single short microvilli.

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

Sign in / Sign up

Export Citation Format

Share Document