Biomolecular Electronics

2016 ◽  
pp. 295-338 ◽  
Keyword(s):  
Biomolecular Electronics

scholarly journals How stable are the collagen and ferritin proteins for application in bioelectronics?

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246180
Author(s):  
Jayeeta Kolay ◽  
Sudipta Bera ◽  
Rupa Mukhopadhyay
Keyword(s):  
Electron Transport ◽  
Structural Characteristics ◽  
Transport Capacity ◽  
Loss Of Function ◽  
Solid State Electron ◽  
Current Sensing ◽  
Surface Integration ◽  
Biomolecular Electronics ◽  
Major Factors ◽  
And Storage

One major obstacle in development of biomolecular electronics is the loss of function of biomolecules upon their surface-integration and storage. Although a number of reports on solid-state electron transport capacity of proteins have been made, no study on whether their functional integrity is preserved upon surface-confinement and storage over a long period of time (few months) has been reported. We have investigated two specific cases—collagen and ferritin proteins, since these proteins exhibit considerable potential as bioelectronic materials as we reported earlier. Since one of the major factors for protein degradation is the proteolytic action of protease, such studies were made under the action of protease, which was either added deliberately or perceived to have entered in the reaction vial from ambient environment. Since no significant change in the structural characteristics of these proteins took place, as observed in the circular dichroism and UV-visible spectrophotometry experiments, and the electron transport capacity was largely retained even upon direct protease exposure as revealed from the current sensing atomic force spectroscopy experiments, we propose that stable films can be formed using the collagen and ferritin proteins. The observed protease-resistance and robust nature of these two proteins support their potential application in bioelectronics.

Scanning probe technology in metalloprotein and biomolecular electronics

2004 ◽  
Vol 151 (2) ◽  
pp. 37 ◽  
Author(s):  
J.J. Davis ◽  
D.A. Morgan ◽  
C.L. Wrathmell ◽  
A. Zhao
Keyword(s):  
Scanning Probe ◽  
Biomolecular Electronics

Biomolecular Electronics:  Protein-Based Associative Processors and Volumetric Memories

1999 ◽  
Vol 103 (49) ◽  
pp. 10746-10766 ◽  
Author(s):  
Robert R. Birge ◽  
Nathan B. Gillespie ◽  
Enrique W. Izaguirre ◽  
Anakarin Kusnetzow ◽  
Albert F. Lawrence ◽  
...  
Keyword(s):  
Biomolecular Electronics

Innovations in Biomolecular Electronics

1999 ◽  
Vol 15 (6) ◽  
pp. 963-963 ◽  
Author(s):  
H. Weetall
Keyword(s):  
Biomolecular Electronics

Bacteriorhodopsin as an electronic conduction medium for biomolecular electronics

2008 ◽  
Vol 37 (11) ◽  
pp. 2422 ◽  
Author(s):  
Yongdong Jin ◽  
Tal Honig ◽  
Izhar Ron ◽  
Noga Friedman ◽  
Mordechai Sheves ◽  
...  
Keyword(s):  
Electronic Conduction ◽  
Biomolecular Electronics

scholarly journals Single-molecule conductance of double-stranded RNA oligonucleotides

2021 ◽  
Author(s):  
Subrata Chandra ◽  
Keshani Pattiya Arachchillage ◽  
Evgenii Kliuchnikov ◽  
Farkhad Maksudov ◽  
Steven Ayoub ◽  
...  
Keyword(s):  
Single Molecule ◽  
Duplex Structure ◽  
Double Stranded Rna ◽  
Oh Groups ◽  
Rna Molecules ◽  
Biomolecular Electronics ◽  
Order Of Magnitude ◽  
Dynamics Simulations ◽  
First Time ◽  
Structural Insights

RNA oligonucleotides are crucial for a range of biological functions and in many biotechnological applications. Herein, we measured, for the first time, the conductance of individual double-stranded (ds)RNA molecules and compared it with the conductance of single DNA:RNA hybrids. The average conductance values are similar for both biomolecules, but the distribution of conductance values shows an order of magnitude higher variability for dsRNA, indicating higher molecular flexibility of dsRNA. Microsecond Molecular Dynamics simulations explain this difference and provide structural insights into the higher stability of DNA:RNA duplex with the atomic level of detail. The rotations of 2’-OH groups of the ribose rings and the bases in RNA strands destabilize the duplex structure by weakening base stacking interactions, affecting charge transport, and making single-molecule conductance of dsRNA more variable (dynamic disorder). The results demonstrate that a powerful combination of state-of-the-art biomolecular electronics techniques and computational approaches can provide valuable insights into biomolecules’ biophysics with unprecedented spatial resolution.

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