Lung transplantation for idiopathic pulmonary fibrosis

2016 ◽  
pp. 183-190
Author(s):  
Joshua C. Grimm ◽  
Leann L. Silhan ◽  
Ashish S. Shah
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation

scholarly journals Sex Differences in the Incidence and Outcomes of Patients Hospitalized by Idiopathic Pulmonary Fibrosis (IPF) in Spain from 2016 to 2019

2021 ◽  
Vol 10 (16) ◽  
pp. 3474
Author(s):  
Belén López-Muñiz Ballesteros ◽  
Marta López-Herranz ◽  
Ana Lopez-de-Andrés ◽  
Valentín Hernandez-Barrera ◽  
Rodrigo Jiménez-García ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Sex Differences ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Primary Diagnosis ◽  
Secondary Diagnosis ◽  
National Hospital ◽  
Hospital Discharges ◽  
Discharge Database

(1) Background: To assess sex differences in the incidence, characteristics, procedures and outcomes of patients admitted with idiopathic pulmonary fibrosis (IPF); and to analyze variables associated with in-hospital mortality (IHM). (2) Methods: We analyzed data collected by the Spanish National Hospital Discharge Database, 2016–2019. (3) Results: We identified 13,278 hospital discharges (66.4% men) of IPF (primary diagnosis 32.33%; secondary diagnosis: 67.67%). Regardless of the diagnosis position, IPF incidence was higher among men than women, increasing with age. Men had 2.74 times higher IPF incidence than women. Comorbidity was higher for men in either primary or secondary diagnosis. After matching, men had higher prevalence of pulmonary embolism and pneumonia, and women of congestive heart failure, dementia, rheumatoid disease and pulmonary hypertension. Invasive ventilation, bronchoscopy and lung transplantation were received more often by men than women. IHM was higher among men with IPF as primary diagnosis than among women and increased with age in both sexes and among those who suffered cancer, pneumonia or required mechanical ventilation. (4) Conclusions: Incidence of IPF was higher among men than women, as well as comorbidity and use of bronchoscopy, ventilation and lung transplantation. IHM was worse among men than women with IPF as primary diagnosis, increasing with age, cancer, pneumonia or mechanical ventilation use.

Patients with idiopathic pulmonary fibrosis referred for lung transplantation: Initial institutional experience in Turkey

2021 ◽  
Vol 28 (5) ◽  
pp. 987
Author(s):  
Mustafa Vayvada ◽  
Ayse Halis ◽  
Pinar Guney ◽  
Sevinc Citak ◽  
Ali Yiginsu ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Institutional Experience

scholarly journals Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease

2021 ◽  
Author(s):  
Jonathan K. Alder ◽  
Rachel M. Sutton ◽  
Carlo J. Iasella ◽  
Mehdi Nouraie ◽  
Ritchie Koshy ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation

Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis

2021 ◽  
pp. 2004053
Author(s):  
Amisha V. Barochia ◽  
Maryann Kaler ◽  
Nargues Weir ◽  
Elizabeth M. Gordon ◽  
Debbie M. Figueroa ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Serum Lipids ◽  
Serum Levels ◽  
High Density Lipoproteins ◽  
Discovery Cohort ◽  
Clinical Endpoints ◽  
Multivariable Analyses ◽  
Lipids And Lipoproteins

BackgroundSerum lipoproteins, such as high density lipoproteins (HDL), may influence disease severity in idiopathic pulmonary fibrosis (IPF). Here, we investigated associations between serum lipids and lipoproteins and clinical endpoints in IPF.MethodsClinical data and serum lipids were analyzed from a discovery cohort (59 IPF subjects, 56 healthy volunteers) and validated using an independent, multicenter cohort (207 IPF subjects) from the Pulmonary Fibrosis Foundation registry. Associations between lipids and clinical endpoints (FVC, forced vital capacity; 6MWD, 6 min walk distance; GAP (Gender Age Physiology) index; death or lung transplantation) were examined using Pearson's correlation and multivariable analyses.ResultsSerum concentrations of small HDL particles (S-HDLPNMR), measured by nuclear magnetic resonance (NMR) spectroscopy, correlated negatively with the GAP index in the discovery cohort of IPF subjects. The negative correlation of S-HDLPNMR with GAP index was confirmed in the validation cohort of IPF subjects. Higher levels of S-HDLPNMR were associated with lower odds of death or its competing outcome, lung transplantation (OR of 0.9 for each 1 μmol·L−1 increase in S-HDLPNMR, p<0.05), at 1, 2, and 3 years from study entry in a combined cohort of all IPF subjects.ConclusionsHigher serum levels of S-HDLPNMR are negatively correlated with the GAP index, as well as with lower observed mortality or lung transplantation in IPF subjects. These findings support the hypothesis that S-HDLPNMR may modify mortality risk in patients with IPF.

scholarly journals Long-Term Combined Training in Idiopathic Pulmonary Fibrosis: A Case Study

2020 ◽  
Vol 17 (14) ◽  
pp. 5091
Author(s):  
José Naranjo-Orellana ◽  
Alfredo Santalla
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Interval Training ◽  
Load Resistance ◽  
Supplemental Oxygen ◽  
Peak Oxygen Uptake ◽  
Combined Training ◽  
Walking Capacity

A supervised combined training program was applied to a sedentary 56-year-old man with idiopathic pulmonary fibrosis (IPF) along three years, until lung transplantation. It included: (a) aerobic continuous (CT) and interval training (IT), (b) high load resistance training (RT) and (c) inspiratory muscle training (IMT). IT and IMT were applied for two years, while CT and RT could be maintained until transplantation using supplemental oxygen. Maximal inspiratory pressure (MIP) kept above 180 cm H2O and forced vital capacity (FVC) remained stable until lung transplantation. Peak oxygen uptake VO2 increased during 1.5 years before its decline, staying above the poor prognosis level two years. Finally, the patient maintained his walking capacity and independence for 2 years, before the decline due to the disease. After receiving a two-lung transplant, the patient remained intubated for 12 h, left the intensive care unit after 3.5 days and was discharged after 18 days (average values: 48 h, 7–10 days and 25–35 days, respectively). These results show that systematic and supervised combined training can be safety applied in an IPF patient to maintain functionality and quality of life. In addition, we show that RT can be maintained for as long as necessary without complications.

scholarly journals Single and Double Lung Transplantation Have Equivalent Survival for Idiopathic Pulmonary Fibrosis

2020 ◽  
Vol 109 (1) ◽  
pp. 211-217 ◽  
Author(s):  
Neel K. Ranganath ◽  
Jad Malas ◽  
Katherine G. Phillips ◽  
Melissa B. Lesko ◽  
Deane E. Smith ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation
Sign in / Sign up

Export Citation Format

Share Document