Adverse Outcome Pathways for Developmental Toxicity

2015 ◽  
pp. 304-337
Keyword(s):  
Adverse Outcome ◽  
Developmental Toxicity ◽  
Adverse Outcome Pathways

scholarly journals SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?

2021 ◽  
Vol 22 (22) ◽  
pp. 12362
Author(s):  
Constantin Yanicostas ◽  
Nadia Soussi-Yanicostas
Keyword(s):  
Oxidative Stress ◽  
Adverse Effects ◽  
Succinate Dehydrogenase ◽  
Adverse Outcome ◽  
Current Knowledge ◽  
Developmental Toxicity ◽  
Axon Growth ◽  
Brachydanio Rerio ◽  
Almost All ◽  
Adverse Outcome Pathways

Succinate dehydrogenase inhibitor (SDHI) fungicides are increasingly used in agriculture to combat molds and fungi, two major threats to both food supply and public health. However, the essential requirement for the succinate dehydrogenase (SDH) complex—the molecular target of SDHIs—in energy metabolism for almost all extant eukaryotes and the lack of species specificity of these fungicides raise concerns about their toxicity toward off-target organisms and, more generally, toward the environment. Herein we review the current knowledge on the toxicity toward zebrafish (Brachydanio rerio) of nine commonly used SDHI fungicides: bixafen, boscalid, fluxapyroxad, flutolanil, isoflucypram, isopyrazam, penthiopyrad, sedaxane, and thifluzamide. The results indicate that these SDHIs cause multiple adverse effects in embryos, larvae/juveniles, and/or adults, sometimes at developmentally relevant concentrations. Adverse effects include developmental toxicity, cardiovascular abnormalities, liver and kidney damage, oxidative stress, energy deficits, changes in metabolism, microcephaly, axon growth defects, apoptosis, and transcriptome changes, suggesting that glycometabolism deficit, oxidative stress, and apoptosis are critical in the toxicity of most of these SDHIs. However, other adverse outcome pathways, possibly involving unsuspected molecular targets, are also suggested. Lastly, we note that because of their recent arrival on the market, the number of studies addressing the toxicity of these compounds is still scant, emphasizing the need to further investigate the toxicity of all SDHIs currently used and to identify their adverse effects and associated modes of action, both alone and in combination with other pesticides.

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

2011 ◽  
pp. n/a-n/a ◽  
Author(s):  
Gerald T. Ankley ◽  
Richard S. Bennett ◽  
Russell J. Erickson ◽  
Dale J. Hoff ◽  
Michael W. Hornung ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Conceptual Framework ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways

scholarly journals An Update on Adverse Outcome Pathways Leading to Liver Injury

2017 ◽  
Vol 3 (4) ◽  
pp. 283-285 ◽  
Author(s):  
Eva Gijbels ◽  
Mathieu Vinken
Keyword(s):  
Liver Injury ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways

Adverse outcome pathways, key events, and radiation risk assessment

2020 ◽  
pp. 1-18
Author(s):  
R. Julian Preston ◽  
Werner Rühm ◽  
Edouard I. Azzam ◽  
John D. Boice ◽  
Simon Bouffler ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Adverse Outcome ◽  
Radiation Risk ◽  
Key Events ◽  
Adverse Outcome Pathways

Adverse Outcome Pathways Knowledge Base (AOP-KB)

2015 ◽  
Vol 238 (2) ◽  
pp. S309
Author(s):  
C. Wittwehr ◽  
S. Munn ◽  
B. Landesmann ◽  
M. Whelan
Keyword(s):  
Knowledge Base ◽  
Adverse Outcome ◽  
Adverse Outcome Pathways
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