Genetic Polymorphisms and Gene–Nutrient Interaction in Metabolic Syndrome

2015 ◽  
pp. 69-114
Author(s):  
Edna Reiche ◽  
Ana Kallaur ◽  
Fernando Reiche ◽  
Paulo Graça
Keyword(s):  
Metabolic Syndrome ◽  
Genetic Polymorphisms ◽  
Nutrient Interaction

scholarly journals Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia

2008 ◽  
Vol 192 (6) ◽  
pp. 424-428 ◽  
Author(s):  
Olga O. Yevtushenko ◽  
Stephen J. Cooper ◽  
Ryan O'Neill ◽  
Jennifer K. Doherty ◽  
Jayne V. Woodside ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Drug Treatment ◽  
Genetic Polymorphisms ◽  
Genetic Risk ◽  
Antipsychotic Drugs ◽  
Genetic Risk Factors ◽  
Metabolic Disturbances ◽  
Genotype Combination ◽  
Increased Risk

BackgroundObesity and metabolic syndrome are significant problems for patients taking antipsychotic drugs. Evidence is emerging of genetic risk factors.AimsTo investigate the influence of two candidate genes, smoking and drug treatment on obesity and metabolic syndrome in patients with schizophrenia.MethodPatients (n=134) were assessed for measures of obesity, other factors contributing to metabolic syndrome, and two genetic polymorphisms (5-HT2C receptor −759C/T and leptin −2548A/G).ResultsNeither genotype nor smoking was significantly associated with measures of obesity. However, both leptin genotype and smoking were significantly associated with metabolic syndrome. Significant interaction occurred between the genetic polymorphisms for effects on obesity, whereby a genotype combination increased risk. Drug treatment showed significant effects on measures of obesity and triglyceride concentrations; risperidone was associated with lower values than olanzapine or clozapine.ConclusionsThe findings suggest interacting genetic risk factors and smoking influence development of metabolic syndrome in patients on antipsychotic drugs.

scholarly journals Association of genetic polymorphisms of PON1 and CETP with the presence of metabolic syndrome; the effects of genotypes on their serum activity and concentrations

2018 ◽  
Vol 19 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Behdokht Fathi Dizaji ◽  
Mahdi Rivandi ◽  
Ali Javandoost ◽  
Maryam Saberi Karimian ◽  
Atena Raei ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Genetic Polymorphisms ◽  
Serum Activity

Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome

2019 ◽  
Vol 47 (2) ◽  
pp. 867-875 ◽  
Author(s):  
Hamideh Ghazizadeh ◽  
Majid Rezaei ◽  
Amir Avan ◽  
Mohammad Fazilati ◽  
Alireza Pasdar ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Genetic Polymorphisms ◽  
Cell Adhesion Molecules ◽  
Hs Crp
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