The Role of Sleep and Light Therapy in Depression

2015 ◽  
pp. 333-355
Author(s):  
Robin May-Davis
Keyword(s):  
Light Therapy

Decoding the Inter-relationship between Sleep Disorders and Alzheimer’s disease Pathogenesis

2020 ◽  
Vol 19 ◽  
Author(s):  
Zeba Mueed ◽  
Pankaj Kumar Rai ◽  
Mohammad A. Kamal ◽  
Nitesh Kumar Poddar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Mammalian Target Of Rapamycin ◽  
Light Therapy ◽  
Paired Helical Filaments ◽  
Bidirectional Relationship ◽  
Causative Agents

Alzheimer’s disease (AD), characterized by abnormally phosphorylated tau, paired helical filaments (PHFs), neurofibrillary tangles (NFTs), deregulated mammalian target of rapamycin (mTOR), Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its association with AD pathology. We have also discussed the role of melatonin in regulating sleep disorders and AD. The neuroprotective action of melatonin via inhibiting tau hyperphosphorylation and Aβ deposition has also been pondered upon. Moreover, astrocytes involvement in aggravating AD has also been highlighted in this review. Several therapeutic approaches aimed at improving both sleep disorders and AD have been duly discussed such as administration of antidepressants and antihistamines, immunotherapy, metal chelators, melatonin supplementation, light therapy and physical activity. Despite consistent efforts, the complete etiology concerning sleep disorder and AD is still unclear. Therefore, further research is needed to unravel the mechanism involved and also to develop strategies that may help in obstructing AD in its preclinical stage.

The Role of Bright Light Therapy in Managing Insomnia

2013 ◽  
Vol 8 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Nicole Lovato ◽  
Leon Lack
Keyword(s):  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy

scholarly journals PHYSICAL FACTORS AND THEIR ROLE IN ONCOLOGY

2019 ◽  
Vol 1 (3) ◽  
pp. 12-17 ◽  
Author(s):  
T Ya Kucherova ◽  
M V Vusik ◽  
O V Cheremisina
Keyword(s):  
Physical Therapy ◽  
Tumor Growth ◽  
Light Therapy ◽  
Physical Factors ◽  
Historical Aspect ◽  
Scientific Results ◽  
Effective Adjunct ◽  
Stimulate Tumor Growth

The analysis of the effect of various physical therapy methods on tumor growth in the historical aspect and comparison with our own scientific results were carried out. The role of physical therapy methods such as galvanization (electrophoresis), light therapy (ultraviolet irradiation, lasers of different light wave spectra), alternating currents (UHF, microwave, inductothermia), mechanical vibrations (ultrasound, vibration), magnetic field, pulse currents (DDT, SMT), high voltage currents (darsonvalization), and thermal factors (mud and heat treatment) in stimulation of tumor growth was studied. The results of our own studies confirm the statement that the physiotherapeutic factors used do not stimulate tumor growth, and can have a beneficial influence on the improvement of the quality of life of cancer patients. Thus, there is a growing evidence that physiotherapy is a safe and effective adjunct to cancer treatment.

Effects of ultraviolet light in vascular cells in vitro and in intact atherosclerotic explants: potential role of apoptosis in vascular biology

1996 ◽  
Vol 74 (3) ◽  
pp. 333-345 ◽  
Author(s):  
Angel López-Candales ◽  
Michael J. Scott ◽  
Samuel A. Wickline ◽  
Dennis R. Holmes ◽  
Robert W. Thompson
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Short Wavelength ◽  
Ex Vivo ◽  
Zealand White Rabbit ◽  
Light Therapy ◽  
Vascular Cells

Complex cell-to-cell interactions are known to participate during vascular injury and remodeling, resulting in smooth muscle cell proliferation. Mechanical interventions have yielded little benefit in limiting this process and several site-specific genetic therapies are not yet clinically available. The aim of this study was to delineate the effect of very short wavelength ultraviolet (UVC) light therapy on the viability of macrophage and smooth muscle cells. Vascular cells were both treated in vitro and in intact explanted atherosclerotic aortic segments ex vivo with UVC light. Brief exposure to short wavelength UVC light in the absence of photosensitizers elicited a differential temporal and functional response among treated cells. However, dramatic reduction in both cellular viability and proliferative capacity with eventual cell demise was observed in all UVC-treated cells. Flow cytometry and immunohistochemical analyses revealed the presence of extensive DNA fragmentation, suggestive of apoptosis as a predominant pathway of cell death in these cells exposed to UVC light. We hypothesize that selective induction of apoptosis, in contrast to necrosis, with UVC light may represent a beneficial approach to interdict the complex biologic cascade of messengers that participate in the restenotic response to vascular injury.Key words: apoptosis, macrophage, smooth muscle cell, atherosclerotic aorta, New Zealand White rabbit.

scholarly journals A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

2022 ◽  
Vol 23 (1) ◽  
pp. 504
Author(s):  
Xuemin Peng ◽  
Rongping Fan ◽  
Lei Xie ◽  
Xiaoli Shi ◽  
Kun Dong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Light Therapy

Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer’s disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms in many diseases. Circadian rhythm disruption is considered to contribute to both T2DM and AD. Here, we review the relationship among circadian rhythm disruption, T2DM and AD, and suggest that the occurrence and progression of T2DM and AD may in part be associated with circadian disruption. Then, we summarize the promising therapeutic strategies targeting circadian dysfunction for T2DM and AD, including pharmacological treatment such as melatonin, orexin, and circadian molecules, as well as non-pharmacological treatments like light therapy, feeding behavior, and exercise.

scholarly journals Low-Intensity Light Therapy: Exploring the Role of Redox Mechanisms

2008 ◽  
Vol 26 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Joseph Tafur ◽  
Paul J. Mills
Keyword(s):  
Light Therapy ◽  
Low Intensity

Can Sunlight Revolutionize the Light Therapy Technique

2021 ◽  
pp. 1-2
Author(s):  
Ali O Islam ◽  
Keyword(s):  
Light Therapy ◽  
Natural Process ◽  
The Sun ◽  
Human History ◽  
Therapy Technique ◽  
Life On Earth

Throughout human history, the role of sunlight to sustain life on earth has been recognized. The contribution of sunlight starts with photosynthesis, promoting the growth of plants and crops, which then feed the entire lifecycle, humans being an integral part of the natural process. Interestingly, over 100 years ago as the plastic revolution began and everything natural started to be replaced with their artificial version, sunlight didn’t lose its appeal. Only recently, scientists started to think of the sun as a liability.

Chronobiology and Chronotherapy in Depression: Current Knowledge and Chronotherapeutic Promises

2021 ◽  
Vol 16 (3) ◽  
pp. 179-193
Author(s):  
Milagros Rojas ◽  
Mervin Chávez-Castillo ◽  
Daniela Pírela ◽  
Ángel Ortega ◽  
Juan Salazar ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Bright Light ◽  
Light Therapy ◽  
Symptoms Of Depression ◽  
Organic Systems ◽  
Treatment Of Depression ◽  
Promising Treatment ◽  
And Behavior ◽  
Pathophysiologic Mechanisms

Background: Depression is a heavily prevalent mental disorder. Symptoms of depression extend beyond mood, cognition, and behavior to include a spectrum of somatic manifestations in all organic systems. Changes in sleep and neuroendocrine rhythms are especially prominent, and disruptions of circadian rhythms have been closely related to the neurobiology of depression. With the advent of increased research in chronobiology, various pathophysiologic mechanisms have been proposed, including anomalies of sleep architecture, the effects of clock gene polymorphisms in monoamine metabolism, and the deleterious impact of social zeitgebers. The identification of these chronodisruptions has propelled the emergence of several chronotherapeutic strategies, both pharmacological and non-pharmacological, with varying degrees of clinical evidence. Methods: The fundamental objective of this review is to integrate current knowledge about the role of chronobiology and depression and to summarize the interventions developed to resynchronize biorhythms both within an individual and with geophysical time. Results: We have found that among the non-pharmacological alternatives, triple chronotherapywhich encompasses bright light therapy, sleep deprivation therapy, and consecutive sleep phase advance therapy-has garnered the most considerable scientific interest. On the other hand, agomelatine appears to be the most promising pharmacological option, given its unique melatonergic pharmacodynamics. Conclusions: Research in chronotherapy as a treatment for depression is currently booming. Novel interventions could play a significant role in adopting new options for the treatment of depression, with Tripe Cronotherapy standing out as the most promising treatment.

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