Articular Cartilage Biomechanics

2008 ◽  
pp. 85-94
Author(s):  
Jennifer Wayne
Keyword(s):  
Articular Cartilage ◽  
Cartilage Biomechanics

scholarly journals Early Detection of Cartilage Degeneration: A Comparison of Histology, Fiber Bragg Grating-Based Micro-Indentation, and Atomic Force Microscopy-Based Nano-Indentation

2020 ◽  
Vol 21 (19) ◽  
pp. 7384
Author(s):  
Bastian Hartmann ◽  
Gabriele Marchi ◽  
Paolo Alberton ◽  
Zsuzsanna Farkas ◽  
Attila Aszodi ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Articular Cartilage ◽  
Fiber Bragg Grating ◽  
Cartilage Degeneration ◽  
Bragg Grating ◽  
Polarization Microscopy ◽  
Force Microscopy ◽  
Fbg Sensor ◽  
Atomic Force ◽  
Cartilage Biomechanics

We have determined the sensitivity and detection limit of a new fiber Bragg grating (FBG)-based optoelectronic micro-indenter for biomechanical testing of cartilage and compared the results to indentation-type atomic force microscopy (IT-AFM) and histological staining. As test samples, we used bovine articular cartilage, which was enzymatically degraded ex vivo for five minutes using different concentrations of collagenase (5, 50, 100 and 500 µg/mL) to mimic moderate extracellular matrix deterioration seen in early-stage osteoarthritis (OA). Picrosirius Red staining and polarization microscopy demonstrated gradual, concentration-dependent disorganization of the collagen fibrillar network in the superficial zone of the explants. Osteoarthritis Research Society International (OARSI) grading of histopathological changes did not discriminate between undigested and enzymatically degraded explants. IT-AFM was the most sensitive method for detecting minute changes in cartilage biomechanics induced by the lowest collagenase concentration, however, it did not distinguish different levels of cartilage degeneration for collagenase concentrations higher than 5 µg/mL. The FBG micro-indenter provided a better and more precise assessment of the level of cartilage degeneration than the OARSI histological grading system but it was less sensitive at detecting mechanical changes than IT-AFM. The FBG-sensor allowed us to observe differences in cartilage biomechanics for collagenase concentrations of 100 and 500 µg/mL. Our results confirm that the FBG sensor is capable of detecting small changes in articular cartilage stiffness, which may be associated with initial cartilage degeneration caused by early OA.

scholarly journals The effect of lipus on tibial articular cartilage biomechanics in rabbit model of OA

2014 ◽  
Vol 22 ◽  
pp. S459
Author(s):  
Z.S. Rezaeian ◽  
G. Torkaman ◽  
R. Ravanbod ◽  
A. Esteki ◽  
A. Sabbaghian
Keyword(s):  
Articular Cartilage ◽  
Rabbit Model ◽  
Cartilage Biomechanics

Human articular cartilage biomechanics of the second metatarsal intermediate cuneiform joint

1997 ◽  
Vol 36 (5) ◽  
pp. 367-374 ◽  
Author(s):  
George T. Liu ◽  
Lawrence A. Lavery ◽  
Robert C. Schenck ◽  
Dan R. Lanctot ◽  
Chong F. Zhu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Human Articular Cartilage ◽  
Second Metatarsal ◽  
Cartilage Biomechanics

scholarly journals Temperature effects in articular cartilage biomechanics

2010 ◽  
Vol 213 (22) ◽  
pp. 3934-3940 ◽  
Author(s):  
R. K. June ◽  
D. P. Fyhrie
Keyword(s):  
Articular Cartilage ◽  
Temperature Effects ◽  
Cartilage Biomechanics

Articular Cartilage Biomechanics Modeled via an Intrinsically Compressible Biphasic Model: Implications and Deviations From an Incompressible Biphasic Approach

2013 ◽  
Author(s):  
Francesco Travascio ◽  
Roberto Serpieri ◽  
Shihab Asfour
Keyword(s):  
Articular Cartilage ◽  
Experimental Testing ◽  
Solid Matrix ◽  
Hydraulic Permeability ◽  
Theoretical Frameworks ◽  
Theoretical Formulation ◽  
New Model ◽  
Biphasic Model ◽  
Testing Procedures ◽  
Cartilage Biomechanics

Biphasic continuum models have been extensively deployed for modeling macroscopic articular cartilage biomechanics [1,2]. This consolidated theoretical approach schematizes tissue as a mixture of an elastic solid matrix embedded in a fluid phase. In physiological conditions, intrinsic compressibility of each phase is very limited when compared to the whole tissue macroscopic counterpart. Based on such experimental evidence, intrinsic phase compressibility is generally reasonably neglected [3]. Hence, traditionally, cartilage biomechanics models have been developed on the basis of incompressible biphasic formulations [3–5], often referred to as Incompressible Theories of Mixtures (ITM). Alternatively, a more general biphasic model for cartilage biomechanics, accounting for full intrinsic compressibility of phases, may be considered. A consistent theoretical formulation of this type has been recently made available [6,7], hereby referred to as Theory of Microscopically Compressible Porous Media (TMCPM). In the present contribution, a new model for articular cartilage biomechanics, based on TMCPM, was developed. Predictions of this new model, and its deviations from a traditional ITM approach were studied. In particular, deviations between compressible and incompressible theoretical frameworks were investigated with a specific focus on the repercussions on models’ capability of characterizing fundamental tissue properties, such as hydraulic permeability, via established experimental testing procedures.

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