Dose–exposure and exposure–response models for longitudi- nal data

2015 ◽  
pp. 55-84
Keyword(s):  
Response Models ◽  
Exposure Response

Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models

2019 ◽  
Vol 21 (5) ◽  
Author(s):  
Theodoros Papathanasiou ◽  
Anders Strathe ◽  
Rune Viig Overgaard ◽  
Trine Meldgaard Lund ◽  
Andrew C. Hooker
Keyword(s):  
Drug Combinations ◽  
Dose Finding ◽  
Response Models ◽  
Exposure Response

scholarly journals Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

2015 ◽  
Vol 4 (1) ◽  
pp. 12-27 ◽  
Author(s):  
DR Mould ◽  
A‐C Walz ◽  
T Lave ◽  
JP Gibbs ◽  
B Frame
Keyword(s):  
Drug Treatment ◽  
Anticancer Drug ◽  
Response Models ◽  
Exposure Response

scholarly journals Effects of Nocturnal Aircraft Noise and Non-Acoustical Factors on Short-Term Annoyance in Primary School Children

2021 ◽  
Vol 18 (13) ◽  
pp. 6959
Author(s):  
Julia Quehl ◽  
Susanne Bartels ◽  
Rolf Fimmers ◽  
Daniel Aeschbach
Keyword(s):  
Primary School ◽  
School Children ◽  
Noise Exposure ◽  
Aircraft Noise ◽  
Primary School Children ◽  
Short Term ◽  
Response Models ◽  
Logistic Regression Models ◽  
Time In Bed ◽  
Exposure Response

Children are considered at higher risk for harmful noise effects due to their sensitive development phase. Here, we investigated the effects of nocturnal aircraft noise exposure on short-term annoyance assessed in the morning in 51 primary school children (8–10 years) living in the surrounding community of Cologne-Bonn Airport. Child-appropriate short-term annoyance assessments and associated non-acoustical variables were surveyed. Nocturnal aircraft noise exposure was recorded inside the children’s bedrooms. Exposure–response models were calculated by using random effects logistic regression models. The present data were compared with those from a previous study near Cologne-Bonn Airport in adults using very similar methodology. Short-term annoyance reaction in children was not affected by the nocturnal aircraft noise exposure. Non-acoustical factors (e.g., the attitude that “aircraft are dangerous” or noise sensitivity), however, significantly impacted on children’s short-term annoyance. In contrast to children, the probability of moderate to high annoyance in adults increased with the number of aircraft flyovers during the time in bed. It is concluded that short-term annoyance from nocturnal aircraft noise in children is mainly determined by non-acoustical factors. Unlike in adults, acoustical factors did not play a significant role.

Differences in the association between the 2018 ACGIH TLV for Hand Activity and carpal tunnel syndrome by gender and age

2021 ◽  
Vol 65 (1) ◽  
pp. 708-709
Author(s):  
C Harris-Adamson ◽  
A Meyers ◽  
R Bonfiglioli ◽  
J Kapellusch ◽  
AM Dale ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Older Workers ◽  
Response Models ◽  
Exposure Response ◽  
Younger Workers ◽  
Increased Risk ◽  
Gender And Age ◽  
Tunnel Syndrome ◽  
Working Populations

The recently revised ACGIH TLV for Hand Activity (TLV2018) is a widely used tool for assessing risk for upper limb musculoskeletal disorders. The purpose of this analysis was to compare the strength of the exposure-response relationships between the TLV2018 and carpal tunnel syndrome (CTS) between men and women and across age strata. Heterogeneity of the effect size by sex or age would be important to specialists using the method for prevention of CTS among working populations. Data from two large prospective studies were combined to allow for stratification of exposure-response models assessing the association between the TLV2018 and CTS by gender and age. Results show greater risk for women than men and for younger workers than older workers for TLV2018 values above the action limit. Although the TLV2018 is an effective surveillance tool for estimating increased risk of CTS with increasing exposure, these analyses show that such increase are not homogeneous across sex and age.

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