Paracoccidioidomycosis: An Endemic Mycosis in the Americas

2015 ◽  
pp. 254-273
Author(s):  
Carlos Taborda ◽  
Luiz Travassos
Keyword(s):  
Endemic Mycosis

scholarly journals PARACOCCIDIOIDOMYCOSIS: CHALLENGES IN THE DEVELOPMENT OF A VACCINE AGAINST AN ENDEMIC MYCOSIS IN THE AMERICAS

2015 ◽  
Vol 57 (suppl 19) ◽  
pp. 21-24 ◽  
Author(s):  
Carlos. P. TABORDA ◽  
M.E. URÁN ◽  
J. D. NOSANCHUK ◽  
L.R. TRAVASSOS
Keyword(s):  
Immune Response ◽  
Latin America ◽  
Monoclonal Antibodies ◽  
Clinical Practice ◽  
Therapeutic Vaccines ◽  
Endemic Mycosis ◽  
Paracoccidioides Spp ◽  
Important Means ◽  
Cellular Immune ◽  
Stimulation Of

SUMMARYParacoccidioidomycosis (PCM), caused by Paracoccidioides spp, is an important endemic mycosis in Latin America. There are two recognized Paracoccidioides species, P. brasiliensis and P. lutzii, based on phylogenetic differences; however, the pathogenesis and disease manifestations of both are indistinguishable at present. Approximately 1,853 (~51,2%) of 3,583 confirmed deaths in Brazil due to systemic mycoses from 1996-2006 were caused by PCM. Antifungal treatment is required for patients with PCM. The initial treatment lasts from two to six months and sulfa derivatives, amphotericin B, azoles and terbinafine are used in clinical practice; however, despite prolonged therapy, relapses are still a problem. An effective Th1-biased cellular immune response is essential to control the disease, which can be induced by exogenous antigens or modulated by prophylactic or therapeutic vaccines. Stimulation of B cells or passive transference of monoclonal antibodies are also important means that may be used to improve the efficacy of paracoccidioidomycosis treatment in the future. This review critically details major challenges facing the development of a vaccine to combat PCM.

scholarly journals Acute Pulmonary Histoplasmosis Outbreak in A Documentary Film Crew Travelling from Guatemala to Australia

2019 ◽  
Vol 4 (1) ◽  
pp. 25 ◽  
Author(s):  
Stephen Muhi ◽  
Amy Crowe ◽  
John Daffy
Keyword(s):  
Medical Care ◽  
Documentary Film ◽  
Histoplasma Capsulatum ◽  
Febrile Illness ◽  
Acute Febrile Illness ◽  
Widespread Distribution ◽  
Endemic Mycosis ◽  
Pulmonary Histoplasmosis ◽  
Vampire Bats

Histoplasma capsulatum is an endemic mycosis with a widespread distribution, although it is infrequently reported in travellers. In April 2018, five television crew members developed an acute febrile illness after filming a documentary about vampire bats in Guatemala. Patients developed symptoms after travelling to Australia, where they presented for medical care.

scholarly journals C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North America

2014 ◽  
Vol 192 (3) ◽  
pp. 1107-1119 ◽  
Author(s):  
Huafeng Wang ◽  
Vanessa LeBert ◽  
Chiung Yu Hung ◽  
Kevin Galles ◽  
Shinobu Saijo ◽  
...  
Keyword(s):  
North America ◽  
Th17 Cells ◽  
Lectin Receptors ◽  
Endemic Mycosis ◽  
Vaccine Immunity

scholarly journals Subacute Histoplasmosis with Focal Involvement of the Epiglottis: Importance of Differential Diagnosis

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
F. Ahumada ◽  
D. Pérez ◽  
M. de Górgolas ◽  
B. Álvarez ◽  
A. Ríos ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Relevant Literature ◽  
Clinical Manifestations ◽  
Spanish Patient ◽  
Endemic Mycosis

Histoplasmosis is an endemic mycosis of the Americas, Africa, and Asia. In Spain, it is the most common imported endemic mycosis appearing in the literature, and its incidence is on the rise. Proper differential diagnosis of the disease must be taken into consideration by otorhinolaryngologists, as the clinical manifestations of histoplasmosis may simulate more prevalent diseases such as cancer or tuberculosis. We present the case of a Spanish patient with focal involvement of the larynx and offer a review of the relevant literature.

scholarly journals Isolation of human fungi from soil and identification of two endemic areas of Cryptococcus neoformans and Coccidioides immitis

1989 ◽  
Vol 31 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Héctor Rubinstein ◽  
Blanca Marticorena ◽  
Diana Masih ◽  
Noemi Borletto ◽  
Raul Vega ◽  
...  
Keyword(s):  
Cryptococcus Neoformans ◽  
Clinical Case ◽  
Soil Samples ◽  
Delayed Hypersensitivity ◽  
Coccidioides Immitis ◽  
Pulmonary Cryptococcosis ◽  
Endemic Mycosis ◽  
High Incidence ◽  
Endemic Areas

The present study was carried out in two different areas of Province of Cordoba, Argentina, where there was a suspicious of endemic mycosis. The previous data were the presence of a clinical case of pulmonary cryptococcosis in one area (Alta Gracia) and the previous findings of a high incidence of coccidioidin and cryptococcin reactors in the population of the second one (Villa Dolores). In both areas soil samples for fungi were studied and Cryptococcus neoformans was found in 2/25 samples from Alta Gracia. In Villa Dolores Coccidioides immitis was isolated in 2/40 samples, and C. neoformans in 1/40 samples. Delayed hypersensitivity test with cryptococcin was determined in the population from Alta Gracia and it was found to be 5.3%. Positive cutaneous tests with coccidioidin (33.8%) and cryptococcin (31.9%) in Villa Dolores were obtained. With these findings two endemic areas of systemic mycoses in Cordoba, Argentina were delimited.

scholarly journals A probable association between HTLV-1 and endemic mycosis in Latin America

2011 ◽  
Vol 6 (03) ◽  
pp. 301
Author(s):  
Mey Leon ◽  
Jorge Alave ◽  
Beatriz Bustamante ◽  
Eduardo Gotuzzo ◽  
Carlos Seas
Keyword(s):  
Latin America ◽  
Full Text ◽  
Endemic Mycosis

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