- Better exposure measurements through better design

2015 ◽  
pp. 302-331
Keyword(s):  
Exposure Measurements

scholarly journals Validation of Lower Tier Exposure Tools Used for REACH: Comparison of Tools Estimates With Available Exposure Measurements

2017 ◽  
Vol 61 (8) ◽  
pp. 921-938 ◽  
Author(s):  
Martie van Tongeren ◽  
Judith Lamb ◽  
John W Cherrie ◽  
Laura MacCalman ◽  
Ioannis Basinas ◽  
...  
Keyword(s):  
Lower Tier ◽  
Exposure Measurements

scholarly journals Evaluation of Exposure Assessment Tools under REACH: Part II—Higher Tier Tools

2018 ◽  
Vol 63 (2) ◽  
pp. 230-241 ◽  
Author(s):  
Eun Gyung Lee ◽  
Judith Lamb ◽  
Nenad Savic ◽  
Ioannis Basinas ◽  
Bojan Gasic ◽  
...  
Keyword(s):  
Exposure Assessment ◽  
Assessment Tools ◽  
Worst Case ◽  
Local Exhaust Ventilation ◽  
Limit Value ◽  
Exposure Category ◽  
Input Parameters ◽  
Full Shift ◽  
Exposure Levels ◽  
Exposure Measurements

Abstract Stoffenmanager®v4.5 and Advanced REACH Tool (ART) v1.5, two higher tier exposure assessment tools for use under REACH, were evaluated by determining accuracy and robustness. A total of 282 exposure measurements from 51 exposure situations (ESs) were collected and categorized by exposure category. In this study, only the results of liquids with vapor pressure (VP) > 10 Pa category having a sufficient number of exposure measurements (n = 251 with 42 ESs) were utilized. In addition, the results were presented by handling/activity description and input parameters for the same exposure category. It should be noted that the performance results of Stoffenmanager and ART in this study cannot be directly compared for some ESs because ART allows a combination of up to four subtasks (and nonexposed periods) to be included, whereas the database for Stoffenmanager, separately developed under the permission of the legal owner of Stoffenmanager, permits the use of only one task to predict exposure estimates. Thus, it would be most appropriate to compare full-shift measurements against ART predictions (full shift including nonexposed periods) and task-based measurements against task-based Stoffenmanager predictions. For liquids with VP > 10 Pa category, Stoffenmanager®v4.5 appeared to be reasonably accurate and robust when predicting exposures [percentage of measurements exceeding the tool’s 90th percentile estimate (%M > T) was 15%]. Areas that could potentially be improved include ESs involving the task of handling of liquids on large surfaces or large work pieces, allocation of high and medium VP inputs, and absence of local exhaust ventilation input. Although the ART’s median predictions appeared to be reasonably accurate for liquids with VP > 10 Pa, the %M > T for the 90th percentile estimates was 41%, indicating that variance in exposure levels is underestimated by ART. The %M > T using the estimates of the upper value of 90% confidence interval (CI) of the 90th percentile estimate (UCI90) was considerably reduced to 18% for liquids with VP > 10 Pa. On the basis of this observation, users might be to consider using the upper limit value of 90% CI of the 90th percentile estimate for predicting reasonable worst case situations. Nevertheless, for some activities and input parameters, ART still shows areas to be improved. Hence, it is suggested that ART developers review the assumptions in relation to exposure variability within the tool, toward improving the tool performance in estimating percentile exposure levels. In addition, for both tools, only some handling/activity descriptions and input parameters were considered. Thus, further validation studies are still necessary.

Shear Stress Exposure Measurements on the Motionless Fluid Diode Valve in the Pulmonary Position

2010 ◽  
Author(s):  
Tiffany Camp ◽  
Richard S. Figliola ◽  
Timothy A. Conover ◽  
T.-Y. Hsia
Keyword(s):  
Congenital Heart Disease ◽  
Shear Stress ◽  
Heart Disease ◽  
Pressure Gradient ◽  
Pulmonary Circulation ◽  
Congenital Heart ◽  
Pulmonary Insufficiency ◽  
Stress Exposure ◽  
Exposure Measurements

Pulmonary insufficiency is one of the consequences of congenital heart disease, and currently no permanent solution exists. The concept of a motionless diode valve to regulate the pulmonary circulation has been proposed and previously studied. The diode valve has shown the ability to regulate flow with levels of regurgitation and pressure gradient that are acceptable within the pulmonary circulation [1].

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