Analysis of energy coupling between the computer chassis and electromagnetic pulse

2015 ◽  
pp. 349-352
Author(s):  
J Liu ◽  
Y Wang ◽  
Z Chen ◽  
C Yu
Keyword(s):  
Electromagnetic Pulse ◽  
Energy Coupling

RF energy coupling to high-pressure optically pumped nonequilibrium plasmas

2001 ◽  
Author(s):  
Peter Palm ◽  
Elke Plonjes ◽  
Wonchul Lee ◽  
Kraig Frederickson ◽  
Walter Lempert ◽  
...  
Keyword(s):  
High Pressure ◽  
Energy Coupling ◽  
Optically Pumped ◽  
Nonequilibrium Plasmas ◽  
Rf Energy

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

2020 ◽  
Author(s):  
Eleonora Diamanti ◽  
Inda Setyawati ◽  
Spyridon Bousis ◽  
leticia mojas ◽  
lotteke Swier ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Energy Coupling ◽  
Coupling Factor ◽  
Design Synthesis ◽  
Screening Design ◽  
Starting Point ◽  
Wide Range ◽  
Vitamin Uptake

Here, we report on the virtual screening, design, synthesis and structure–activity relationships (SARs) of the first class of selective, antibacterial agents against the energy-coupling factor (ECF) transporters. The ECF transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that depend on vitamin uptake. Because of their central role in the metabolism of bacteria and their absence in humans, ECF transporters are novel potential antimicrobial targets to tackle infection. The hit compound’s metabolic and plasma stability, the potency (20, MIC Streptococcus pneumoniae = 2 µg/mL), the absence of cytotoxicity and a lack of resistance development under the conditions tested here suggest that this scaffold may represent a promising starting point for the development of novel antimicrobial agents with an unprecedented mechanism of action.<br>

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