The protective potential of fasudil hydrochloride in liver injury induced by intestinal ischemia reperfusion in rats

2015 ◽  
pp. 335-340
Keyword(s):  
Liver Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Protective Potential ◽  
Intestinal Ischemia Reperfusion

scholarly journals Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Xin Fan ◽  
Juan Du ◽  
Mao-Hua Wang ◽  
Jia-Man Li ◽  
Bo Yang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Nlrp3 Inflammasome ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Neutralizing Antibody ◽  
Inflammasome Activation ◽  
High Morbidity ◽  
Antibody Treatment ◽  
Sod Activity ◽  
Intestinal Ischemia Reperfusion

Intestinal ischemia/reperfusion (I/R), which is associated with high morbidity and mortality, is also accompanied with abnormal energy metabolism and liver injury. Irisin, a novel exercise-induced hormone, can regulate adipose browning and thermogenesis. The following study investigated the potential role of dexmedetomidine in liver injury during intestinal I/R in rats. Adult male Sprague–Dawley rats underwent occlusion of the superior mesenteric artery for 90 min followed by 2 h of reperfusion. Dexmedetomidine or irisin-neutralizing antibody was intravenously administered for 1 h before surgery. The results demonstrated that severe intestine and liver injuries occurred during intestinal I/R as evidenced by pathological scores and an apparent increase in serum diamine oxidase (DAO), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels. In addition, the hepatic irisin, cleaved caspase-3, Bax, and NLRP3 inflammasome components (including NLRP3, ASC, and caspase-1), protein expressions, apoptotic index, reactive oxygen species (ROS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 levels increased; however, the serum irisin level and hepatic Bcl-2 protein expression and superoxide dismutase (SOD) activity decreased after intestinal I/R. Interestingly, dexmedetomidine could reduce the above listed changes and increase the irisin levels in plasma and the liver in I/R rats. Dexmedetomidine-mediated protective effects on liver injury and NLRP3 inflammasome activation during intestinal I/R were partially abrogated via irisin-neutralizing antibody treatment. The results suggest that irisin might contribute to the hepatoprotection of dexmedetomidine during intestinal ischemia/reperfusion.

N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion

2016 ◽  
Vol 206 (2) ◽  
pp. 263-272 ◽  
Author(s):  
Konstantinos Kalimeris ◽  
Panagiotis Briassoulis ◽  
Agathi Ntzouvani ◽  
Tzortzis Nomikos ◽  
Kleio Papaparaskeva ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion

2013 ◽  
Vol 48 (8) ◽  
pp. 1707-1715 ◽  
Author(s):  
Mustafa Inan ◽  
Yesim Hulya Uz ◽  
Gulnur Kizilay ◽  
Yeter Topcu-Tarladacalisir ◽  
Melike Sapmaz-Metin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion

scholarly journals Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion

2009 ◽  
Vol 15 (26) ◽  
pp. 3240 ◽  
Author(s):  
Ji-Hong Yao ◽  
Xue-Song Zhang ◽  
Shu-Sen Zheng ◽  
Ying-Hua Li ◽  
Li-Ming Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Intestinal Ischemia Reperfusion
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