Animal Model Cluster IDs: Mechanisms and Risk Factors for SUDEP

2015 ◽  
pp. 157-164
Author(s):  
Claire Lathers
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Model Cluster

Recombinant human regenerating gene 4 attenuates the severity of osteoarthritis by promoting the proliferation of articular chondrocyte in an animal model

2021 ◽  
Vol 14 ◽  
Author(s):  
Xue-jia Li ◽  
Fei Zhu ◽  
Bo Li ◽  
Dong Zhang ◽  
Cheng-Wei Liang
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Sprague Dawley ◽  
Articular Chondrocyte ◽  
Chondrocyte Proliferation ◽  
Histological Changes ◽  
Proper Role ◽  
Sprague Dawley Rats ◽  
Gene 4

Introduction: Osteoarthritis (OA) is a dominant cause of morbidity and disability. As a chronic disease, its etiological risk factors and most therapies at present, are empirical and symptomatic. Regenerating gene 4 (Reg4) is involved in cell growth, survival, regeneration, adhesion, and resistance to apoptosis, which are partially thought to be the pathogenic mechanisms of OA. However, the proper role of Reg4 in OA is still unknown. Methods: In this study, a consecutive administration of rhReg4 was applied to normal Sprague-Dawley rats or rats after OA induction. Histological changes and chondrocyte proliferation in the articular cartilage were measured. Results: We found that RhReg4 promotes chondrocyte proliferation in normal rats, and RhReg4 attenuated the severity of OA in rats by promoting chondrocytes’ proliferation in OA rats. Conclusion: In conclusion, recombinant human regenerating gene 4 (rhReg4) attenuates the severity of osteoarthritis in OA animal models and may be used as a new method for the treatment of osteoarthritis.

scholarly journals Influence of a probiotic soy product on fecal microbiota and its association with cardiovascular risk factors in an animal model

2011 ◽  
Vol 10 (1) ◽  
pp. 126 ◽  
Author(s):  
Daniela CU Cavallini ◽  
Juliana Y Suzuki ◽  
Dulcinéia SP Abdalla ◽  
Regina C Vendramini ◽  
Nadiége D Pauly-Silveira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Fecal Microbiota

scholarly journals A Rhesus Monkey Model of Non-suicidal Self-Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Melinda A. Novak ◽  
Jerrold S. Meyer
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Rhesus Monkey ◽  
Treatment Modalities ◽  
Behavioral Correlates ◽  
Pharmacological Agents ◽  
Monkey Model ◽  
Self Injury ◽  
Potential Risk Factors ◽  
Clinical Conditions

Non-suicidal self-injury (NSSI) is a type of behavioral pathology seen not only in a variety of clinical conditions but also among non-clinical populations, particularly adolescents and young adults. With the exception of rare genetic conditions that give rise to self-harming behaviors, the etiology of NSSI and the events that trigger specific episodes of this behavior remain poorly understood. This review presents the features of an important, extensively studied animal model of NSSI, namely spontaneously occurring self-injurious behavior (SIB) in rhesus macaque monkeys. We compare and contrast rhesus monkey SIB with NSSI with respect to form, prevalence rates, environmental and biological risk factors, behavioral correlates, proposed functions, and treatment modalities. Many parallels between rhesus monkey SIB and NSSI are demonstrated, which supports the validity of this animal model across several domains. Determining the etiology of spontaneously occurring SIB in monkeys, its underlying biological mechanisms, and which pharmacological agents are most effective for treating the disorder may aid in identifying potential risk factors for the occurrence of NSSI in humans and developing medications for severe cases that are resistant to conventional psychotherapeutic approaches.

scholarly journals MP24-03 FECAL TRANSPLANT MODULATES URINARY STONE RISK FACTORS IN AN ANIMAL MODEL

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Joshua Stern ◽  
Robert Burk ◽  
Daniel Schoenfeld ◽  
Kelvin Davies ◽  
John Asplin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Urinary Stone ◽  
Fecal Transplant

scholarly journals An experimental model for hypertensive crises emergencies: Long-term high-fat diet followed by acute vasoconstriction stress on spontaneously hypertensive rats

2018 ◽  
Vol 243 (5) ◽  
pp. 481-495
Author(s):  
Hong Liu ◽  
Wei-Wei Su ◽  
Chao-Feng Long ◽  
Wei-Jian Zhang ◽  
Pei-Bo Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Early Intervention ◽  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
High Fat ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hypertensive Crises

Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0.8 mg/kg). Forty-four biochemical parameters were detected, covering hepatic and renal function, blood glucose and lipid levels, myocardial enzymes and energy metabolisms, blood coagulative and anti-coagulative system, oxidative stress and anti-inflammatory cytokine, blood viscosity, and RAAS system. Six tissues including heart, brain, liver, kidney, coronary arteries, and mesenteries were removed for pathological observations with hematoxylin–eosin staining. As a result, multi-organ dysfunctions in the heart, brain, liver, kidney, vascular endothelium, and blood system were testified in the modeling rats at weeks 6 and 8. In conclusion, severe consequences of this animal model were highly similar to those in hypertensive crises emergencies, which could be further utilized in the early intervention of hypertensive crises emergencies including the possible risk factors control and efficient therapies assessment. Impact statement In the late 90s, numerous reports predicted that 1–2% of hypertensive individuals would undergo hypertensive crises (HPC) and figures reached as high as 7% when no antihypertensive therapies were administrated. Currently, clinical failures appear frequently due to the improper or excessive medication regimen instead of the illness itself. Therefore, early evaluations and observations of HPC on appropriate animal models ahead of patients should be discussed and emphasized more widely. In the present study, an appropriate animal model for HPC emergencies was firstly established, in which the consequences of long-term high-fat diet feeding followed by an acute vasoconstriction stress on the spontaneously hypertensive rats were experimentally testified. The proposed model would have a wide application prospects in early intervention of HPC emergencies including the controls of possible risk factors and assessments of efficient therapies.

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