A Research Note on Kinetics of Release Medicinal Substances from Chitosan Films

2015 ◽  
pp. 47-55
Author(s):  
Angela Shurshina ◽  
Elena Kulish ◽  
Roman Lazdin
Keyword(s):  
Research Note ◽  
Medicinal Substances ◽  
Chitosan Films ◽  
Kinetics Of

scholarly journals Study of Kinetics of Medicinal Substances Release from Chitosan Films

2015 ◽  
Vol 9 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Angela Shurshina ◽  
◽  
Elena Kulish ◽  
Roman Lazdin ◽  
◽  
...  
Keyword(s):  
Medicinal Substances ◽  
Chitosan Films ◽  
Kinetics Of

Adsorptive removal kinetics of anionic dye onto chitosan films doped with graphene oxide: An in situ fluorescence monitoring

2018 ◽  
Vol 205 (7) ◽  
pp. 881-887 ◽  
Author(s):  
Nilay Kahya ◽  
Semira Bener ◽  
Hakan Kaygusuz ◽  
Gülşen Akın Evingür ◽  
F. Bedia Erim
Keyword(s):  
Graphene Oxide ◽  
Adsorptive Removal ◽  
Anionic Dye ◽  
Chitosan Films ◽  
Kinetics Of

scholarly journals Research of the adsorption of aliphatic carboxylic acids on the surface of polysorb

2020 ◽  
Vol 64 (10) ◽  
pp. 63-67
Author(s):  
Alexander A. Kimyashov ◽  
◽  
Alexander V. Syromolotov ◽  
Maksim O. Pavlov ◽  
◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Carboxylic Acids ◽  
Targeted Delivery ◽  
Overweight People ◽  
Saturation Region ◽  
Highly Dispersed ◽  
Medicinal Substances ◽  
Pseudo Second Order ◽  
Aliphatic Carboxylic Acids ◽  
Kinetics Of

The enterosorbent "Polysorb" is a highly dispersed powder of silicon dioxide. In medicine, it is used as a detoxifier for poisoning with organic substances and heavy metals. Recently, the direction in pharmaceuticals related to targeted delivery of medicines has begun to develop. One of the carriers of medicinal substances is highly dispersed silicon dioxide. There are explorations that show that with simultaneous oral administration of highly dispersed silicon dioxide and the antibiotic amphotericin, the concentration of the latter in the blood increases significantly. Recently, there have been studies showing that delivering propionic acid to the gut reduces fat accumulation in overweight people. The goal of this work is study the adsorption of aliphatic carboxylic acids, namely: formic, acetic, propionic on the surface of polysorb. Using electron microscopy, it was shown that polysorb powder consists of particles of different sizes and shapes. Their size varies from units to tens of micrometers. Adsorption isotherms of formic, acetic, and propionic acids were constructed at a temperature of 295 K. It is shown that they have an S-shaped character, therefore, adsorption is due to the formation of hydrogen bonds between the silanol groups of the hydrated POLYSORB and the carboxyl groups of acids. It is established that these isotherms are adequately described by the Freundlich model up to the saturation region. With an increase in the hydrocarbon radical, the adsorption capacity of acids decreases. The kinetics of acid adsorption on the polysorb surface was described using pseudo-first and pseudo-second order models. It was found that the adsorption kinetics of carboxylic acids is adequately described by the pseudo-first-order model. The time of onset of adsorption equilibrium is 30 seconds at a temperature of 295 K.

STUDY OF THE PROLONGING EFFECT DUE TO THE INTERACTION OF POLYCOMPLEX COMPOSITES WITH MEDICINAL SUBSTANCES

ASJ. ◽  
2020 ◽  
Vol 1 (39) ◽  
pp. 23-28
Author(s):  
S.Ya Inagamov ◽  
K.K. Shadmanov ◽  
G.I. Muhamedov
Keyword(s):  
Experimental Data ◽  
Ir Spectroscopy ◽  
Slow Release ◽  
Medicinal Substances ◽  
Kinetics Of

The nature of the formation of polycomplexes and polycomplex composites was investigated by IR spectroscopy, and the kinetics of the release of drugs from the base were studied by the pharmacokinetic method. Experimental data obtained under “in vitro” conditions showed a prolonging effect in comparison with the initial polymers (Na – CMC) and hydrophobic petrolatum (control), which can be explained by the interaction of drugs with polycomplexes and polycomplex composites. It was found that a high prolonging effect of drugs due to their slow release from the base layers of polycomplex composites.

EXPRESS METHOD OF QUALITY CONTROL OF DRUGS BY AUTHENTICITY INDICATOR

2020 ◽  
pp. 28-31
Author(s):  
Tarabrina I.V.
Keyword(s):  
Mathematical Model ◽  
Quality Control ◽  
Dosage Forms ◽  
Topological Descriptors ◽  
Express Method ◽  
Back Scattering ◽  
Medicinal Substances ◽  
Tablet Dosage ◽  
Kinetics Of

The work is devoted to the development of an express method of quality control according to the "authenticity indicator" for the drug "Anaferon". The spectra of micron vibration of the surface of the samples were obtained, based on the dependences of topological descriptors on time. Anaferon preparations, its placebo and intact lactose were investigated by the express 2D-DLS method based on the kinetics of changes in the back scattering using a mathematical model of processing. It has been shown that anaferon - powdered medicinal substances and tablet dosage forms - can be reliably distinguished from placebo.

Sign in / Sign up

Export Citation Format

Share Document