Clinical applications and side effects of ketamine

Ketamine ◽  
2015 ◽  
pp. 28-51 ◽  
Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1379 ◽  
Author(s):  
Sarah Stewart ◽  
Juan Domínguez-Robles ◽  
Ryan Donnelly ◽  
Eneko Larrañeta

The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.


Author(s):  
Adam K. Jacob ◽  
James R. Hebl

Ankle blockade is a safe, efficacious, and well-tolerated anesthetic for foot and ankle surgery The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications.


Author(s):  
Adam K. Jacob

Sciatic nerve blockade is performed to achieve anesthesia and analgesia of the distal lower extremity, including the anterior and posterolateral leg, ankle, and foot. The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications. Use of ultrasound guidance is also discussed.


Author(s):  
David E. Byer

Wrist blockade anesthetizes the median, ulnar, and radial nerves at the level of the wrist. The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications.


Author(s):  
Michelle A. O. Kinney

The intersternocleidomastoid block is indicated for procedures of the shoulder, upper arm, and forearm. The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications.


Author(s):  
Linwei Lu ◽  
Jianhua Huang ◽  
Xiaohong Deng ◽  
Xianjun Sun ◽  
Jingcheng Dong

Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19). This paper briefly summarizes the mechanism of glucocorticoids and their receptors and clinical applications in COVID-19. Through reviewing the current literature, our aim is to have a deeper understanding of the mechanism of GCs and their clinical applications, so as to find possible ways to enhance their efficacy and reduce drug resistance or side effects.


Author(s):  
David E. Byer

Digital nerve blocks are used to provide anesthesia to one or more fingers or toes The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications.


Author(s):  
Thomas J. Jurrens

Suprascapular blockade provides analgesia of the shoulder joint, capsule, and skin without anesthetizing the phrenic nerve. The following aspects of the procedure are reviewed: clinical applications, relevant anatomy, patient position, technique (including neural localization techniques, needle insertion site, and needle redirection cues), and side effects and complications.


Ketamine ◽  
2015 ◽  
pp. 13-36 ◽  
Author(s):  
Ou Sha ◽  
Yue Hao ◽  
Eric Cho ◽  
Li Zhou

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