Postmortem toxicology of ketamine

Ketamine ◽  
2015 ◽  
pp. 243-248 ◽  
Author(s):  
James Watterson
Keyword(s):  
Postmortem Toxicology

scholarly journals Postmortem Toxicology Findings of Acetyl Fentanyl, Fentanyl, and Morphine in Heroin Fatalities in Tampa, Florida

2015 ◽  
Vol 5 (4) ◽  
pp. 676-689 ◽  
Author(s):  
Julia Pearson ◽  
Justin Poklis ◽  
Alphonse Poklis ◽  
Carl Wolf ◽  
Mary Mainland ◽  
...  
Keyword(s):  
Postmortem Toxicology ◽  
Acetyl Fentanyl

scholarly journals Issues in the interpretation of postmortem toxicology

2011 ◽  
Vol 8 (3) ◽  
pp. 205-207 ◽  
Author(s):  
Roger W. Byard ◽  
Danielle M. Butzbach
Keyword(s):  
Postmortem Toxicology

scholarly journals Evaluation of Intraosseous Fluid as an Alternative Biological Specimen in Postmortem Toxicology

2017 ◽  
Vol 42 (3) ◽  
pp. 163-169 ◽  
Author(s):  
Luke N Rodda ◽  
Justin A Volk ◽  
Ellen Moffat ◽  
Chinyere M Williams ◽  
Kara L Lynch ◽  
...  
Keyword(s):  
Biological Specimen ◽  
Postmortem Toxicology

Method Consolidation to Improve Scope and Efficiency in Postmortem Toxicology

2020 ◽  
Vol 44 (5) ◽  
pp. 422-439 ◽  
Author(s):  
Jirair Gevorkyan ◽  
Megan Wong ◽  
Sue Pearring ◽  
Luke N Rodda
Keyword(s):  
Mass Spectrometry ◽  
San Francisco ◽  
Drugs Of Abuse ◽  
Sample Volume ◽  
Gas Chromatography Mass Spectrometry ◽  
Medical Examiner ◽  
Minimal Sample ◽  
Postmortem Toxicology ◽  
Liquid Chromatography Tandem Mass ◽  
Automated Processing

Abstract Systematic toxicological approaches that employ both ideology changes and improvements in instrumentation and sample extraction allow for improved toxicology testing efficiency through lower sensitivities, higher specificity and minimized resource use. Historically, the San Francisco Office of the Chief Medical Examiner relied heavily on a gas chromatography mass spectrometry (GC–MS) testing regime, comprised of individual drug-class confirmation and quantitation assays. Traditional methods utilizing GC–MS typically require iterations of testing, exhausting sample volume, and hindering productivity and turnaround times, particularly for polypharmacy cases frequently seen in modern postmortem toxicology. The method described here consolidated the scope of seven legacy methods into a single liquid chromatography tandem mass spectrometry (LC–MS/MS) method for better sensitivity, higher throughput, minimal sample consumption for the quantitation of drugs of abuse and improved quality assurance with the incorporation of smart, automated processing. About 100 μL of blood or urine were rapidly extracted using a simple acetonitrile protein crash and subsequent in-vial filtration and injected on to an LC–MS-MS system. The developed method was fully validated to SWGTOX and international guidelines and incorporated 55 analytes along with a customized query that facilitates rapid and consistent application of acceptability criteria for data processing and review. Applicability was demonstrated with the analysis of 1,389 samples (858 blood and 531 urine) where at least 41% of positive results may have been missed due to their decreased sensitivity and 11% of results were not within the scope of the previous analytical methods estimated. On average, cases in this study would have previously required three distinct GC–MS assays, 3 mL of blood, and upwards of 30 h of active staff time. The described LC–MS-MS analytical approach has mitigated the need to perform multiple assays, utilized only 0.1 mL of sample, significantly reduced analyst work time, incorporated 10 additional analytes and allowed for a more comprehensive testing regime to better inform cause of death determinations.

Profiles of pregabalin and gabapentin abuse by postmortem toxicology

2014 ◽  
Vol 241 ◽  
pp. 1-6 ◽  
Author(s):  
Margareeta Häkkinen ◽  
Erkki Vuori ◽  
Eija Kalso ◽  
Merja Gergov ◽  
Ilkka Ojanperä
Keyword(s):  
Postmortem Toxicology

Postmortem Toxicology of Abused Drugs

2008 ◽  
Vol 46 (10) ◽  
pp. 1104-1104
Author(s):  
Jerrold B. Leikin ◽  
Steven B. Karch
Keyword(s):  
Postmortem Toxicology ◽  
Abused Drugs

scholarly journals Postmortem Toxicology of Carbamazepine

2003 ◽  
Vol 27 (4) ◽  
pp. 243-248 ◽  
Author(s):  
Malgorzata Klys ◽  
Beata Bystrowska ◽  
Beata Bujak-Gizycka
Keyword(s):  
Postmortem Toxicology
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