PK/TK of Xenobiotics Absorbed through the Skin (Transdermal Absorption)

2015 ◽  
pp. 418-445 ◽  
Keyword(s):  
Transdermal Absorption

Transdermal absorption of active substances from cosmetic vehicles

2019 ◽  
Vol 18 (5) ◽  
pp. 1410-1415 ◽  
Author(s):  
Jana Pavlačková ◽  
Pavlína Egner ◽  
Jana Polašková ◽  
Jarmila Hojerová ◽  
Lucie Pinďáková ◽  
...  
Keyword(s):  
Transdermal Absorption ◽  
Active Substances

Transdermal Absorption of Dimethindene in Man

1995 ◽  
Vol 328 (2) ◽  
pp. 127-129
Author(s):  
Susanne Radler ◽  
Gottfried Blaschke
Keyword(s):  
Transdermal Absorption

scholarly journals Effect of drug lipophilicity and polar surface area on iontophoretic transdermal absorption.

2001 ◽  
Vol 16 (5) ◽  
pp. 419-423
Author(s):  
Yoshikazu Tashiro ◽  
Mari Sami ◽  
Shozo Shichibe ◽  
Yasuki Kato ◽  
Eiji Hayakawa ◽  
...  
Keyword(s):  
Surface Area ◽  
Polar Surface Area ◽  
Polar Surface ◽  
Transdermal Absorption

Transdermal Absorption Kinetics

1985 ◽  
pp. 19-31 ◽  
Author(s):  
RICHARD H. GUY ◽  
JONATHAN HADGRAFT ◽  
HOWARD I. MAIBACH
Keyword(s):  
Absorption Kinetics ◽  
Transdermal Absorption

scholarly journals Verification of P-Glycoprotein Function at the Dermal Barrier in Diffusion Cells and Dynamic “Skin-On-A-Chip” Microfluidic Device

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 804
Author(s):  
Ágnes Bajza ◽  
Dorottya Kocsis ◽  
Orsolya Berezvai ◽  
András József Laki ◽  
Bence Lukács ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Topical Administration ◽  
Transdermal Absorption ◽  
P Glycoprotein ◽  
Diffusion Cells ◽  
Defensive Role ◽  
Dermal Drug Delivery

The efficacy of transdermal absorption of drugs and the irritation or corrosion potential of topically applied formulations are important areas of investigation in pharmaceutical, military and cosmetic research. The aim of the present experiments is to test the role of P-glycoprotein in dermal drug delivery in various ex vivo and in vitro platforms, including a novel microchip technology developed by Pázmány Péter Catholic University. A further question is whether the freezing of excised skin and age have any influence on P-glycoprotein-mediated dermal drug absorption. Two P-glycoprotein substrate model drugs (quinidine and erythromycin) were investigated via topical administration in diffusion cells, a skin-on-a-chip device and transdermal microdialysis in rat skin. The transdermal absorption of both model drugs was reduced by P-glycoprotein inhibition, and both aging and freezing increased the permeability of the tissues. Based on our findings, it is concluded that the process of freezing leads to reduced function of efflux transporters, and increases the porosity of skin. P-glycoprotein has an absorptive orientation in the skin, and topical inhibitors can modify its action. The defensive role of the skin seems to be diminished in aged individuals, partly due to reduced thickness of the dermis. The novel microfluidic microchip seems to be an appropriate tool to investigate dermal drug delivery.

Transdermal absorption of L-deprenyl

1990 ◽  
Vol 183 (2) ◽  
pp. 367-368
Author(s):  
K. Magyar ◽  
K. Kovács ◽  
J. Lengyel ◽  
L. Darkó
Keyword(s):  
Transdermal Absorption

Transdermal absorption enhancement of papain loaded in elastic niosomes incorporated in gel for scar treatment

2013 ◽  
Vol 48 (3) ◽  
pp. 474-483 ◽  
Author(s):  
Aranya Manosroi ◽  
Charinya Chankhampan ◽  
Worapaka Manosroi ◽  
Jiradej Manosroi
Keyword(s):  
Absorption Enhancement ◽  
Transdermal Absorption ◽  
Scar Treatment
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