The Anti-Inflammatory Properties of Different Naturally Occurring Halloysites

2015 ◽  
pp. 475-486
Keyword(s):  
Naturally Occurring ◽  
Anti Inflammatory

scholarly journals Pharmacologic Activities¬ of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity

2015 ◽  
Vol 18 (4) ◽  
pp. 713 ◽  
Author(s):  
Jody K Takemoto ◽  
Connie M. Remsberg ◽  
Neal M. Davies
Keyword(s):  
Histone Deacetylase ◽  
Inhibitory Activity ◽  
Sirtuin 1 ◽  
In Vitro Assays ◽  
Naturally Occurring ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
First Time ◽  
Stilbene Compounds

Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’-Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated.  Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats

1991 ◽  
Vol 12 (10) ◽  
pp. 1949-1952 ◽  
Author(s):  
Takuji Tanaka ◽  
Toshihiro Kojima ◽  
Naoki Yoshimi ◽  
Shigeyuki Sugie ◽  
Hideki Mori
Keyword(s):  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Naturally Occurring ◽  
Anti Inflammatory

THE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENT

1957 ◽  
Vol 79 (20) ◽  
pp. 5577-5578 ◽  
Author(s):  
F. A. Kuehl ◽  
T. A. Jacob ◽  
O. H. Ganley ◽  
R. E. Ormond ◽  
M. A. P. Meisinger
Keyword(s):  
Inflammatory Agent ◽  
Naturally Occurring ◽  
Anti Inflammatory

Synthesis and evaluation of antibacterial and anti-inflammatory properties of naturally occurring coumarins

2015 ◽  
Vol 13 ◽  
pp. 399-405 ◽  
Author(s):  
Jabrane Azelmat ◽  
Serena Fiorito ◽  
Vito Alessandro Taddeo ◽  
Salvatore Genovese ◽  
Francesco Epifano ◽  
...  
Keyword(s):  
Naturally Occurring ◽  
Anti Inflammatory

scholarly journals Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.

2017 ◽  
Vol 8 (3) ◽  
pp. 975-984 ◽  
Author(s):  
Inés Jabeur ◽  
Natália Martins ◽  
Lillian Barros ◽  
Ricardo C. Calhelha ◽  
Josiana Vaz ◽  
...  
Keyword(s):  
Biological Activities ◽  
Phenolic Composition ◽  
Naturally Occurring ◽  
Antitumor Potential ◽  
Tilia Platyphyllos ◽  
Anti Inflammatory

Naturally-occurring phytochemicals have received pivotal attention in the last few years, due to the increasing evidence of biological activities.

scholarly journals Strong and Long-Lasting Antinociceptive and Anti-inflammatory Conjugate of Naturally Occurring Oleanolic Acid and Aspirin

2016 ◽  
Vol 7 ◽  
Author(s):  
Barbara Bednarczyk-Cwynar ◽  
Natalia Wachowiak ◽  
Michal Szulc ◽  
Ewa Kamińska ◽  
Anna Bogacz ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Naturally Occurring ◽  
Anti Inflammatory

scholarly journals UPEI-400, a Conjugate of Lipoic Acid and Scopoletin, Mediates Neuroprotection in a Rat Model of Ischemia/Reperfusion

2016 ◽  
Author(s):  
Barry J. Connell ◽  
Monique C. Saleh ◽  
Desikan Rajagopal ◽  
Tarek M. Saleh
Keyword(s):  
Cell Death ◽  
Lipoic Acid ◽  
Ischemia Reperfusion ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Covalent Bond ◽  
Male Rats ◽  
In Vivo Model ◽  
Naturally Occurring ◽  
Anti Inflammatory

Background: Previously, our laboratory has provided evidence that pre-administration of the antioxidant, lipoic acid covalently bonded to various naturally occurring antioxidants, enhanced neuroprotective capacity compared to the administration of lipoic acid on its own. The naturally occurring compound scopoletin, a coumarin derivative, has been shown in various in vitro studies to have both antioxidant and anti-inflammatory mechanism of actions. To date, the effect of scopoletin on neuronal cell death in an in vivo model of ischemia or ischemia-reperfusion has not been investigated. Therefore, the present investigation was designed to determine if scopoletin on its own, or a co-drug consisting of lipoic acid and scopoletin covalent bond, named UPEI-400, would be capable of demonstrating a similar neuroprotective efficacy. Methods: Using a rodent model of stroke in male rats (anesthetized with Inactin®; 100 mg/kg, iv), the middle cerebral artery was permanently occluded for 6 hours (pMCAO), or in separate animals, occluded for 30 min followed by 5.5 hrs of reperfusion (ischemia/reperfusion; I/R). Results: Pre-administration of either scopoletin or UPEI-400 significantly decreased infarct volume in the I/R model (p<0.05), but not in the pMCAO model of stroke. However, UPEI-400 was ~1000 times more potent as compared to scopoletin on its own. The optimal dose of UPEI-400 was then injected during the occlusion and at several time points during reperfusion and significant neuroprotection was observed for up to 150 mins following the start of reperfusion (p<0.05). Conclusion: The data suggest that synthetic combination of scopoletin with lipoic acid (UPEI-400) is a more effective neuroprotectant that either compound on their own. Also, since UPEI-400 was only effective in a model of I/R, it is possible that it may act to enhance neuronal antioxidant capacity and/or upregulate anti-inflammatory pathways to prevent the neuronal cell death.

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