Morphological Analysis of Work Activity

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

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Social capital as a function of interethnic community service work activity

PsycEXTRA Dataset ◽

10.1037/e683152011-450 ◽

2011 ◽

Author(s):

August John Hoffman

Keyword(s):

Social Capital ◽

Community Service ◽

Service Work ◽

Work Activity

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Dilemmas at a Primary Health Care Center: a baseline study for Computer-Supported Cooperative Health Care Work

Methods of Information in Medicine ◽

10.1055/s-0038-1634874 ◽

1992 ◽

Vol 31 (03) ◽

pp. 204-209 ◽

Cited By ~ 7

Author(s):

T. Timpka ◽

J. M. Nyce

Keyword(s):

Health Care ◽

Primary Health Care ◽

General Practitioners ◽

Group Process ◽

Critical Incident ◽

Care Work ◽

Work Activity ◽

Health Care Center ◽

Health Care Work ◽

Primary Health

Abstract:For the development of computer-supported cooperative health care work this study investigated, based upon activity theory, daily dilemmas encountered by the members of interprofessional primary health care work groups. The entire staff at four Swedish primary health care centers were surveyed, 199 personal interviews being conducted by the Critical Incident Technique. Medical dilemmas were mainly reported by general practitioners and nurses, organizational dilemmas by laboratory staff, nurses’ aides, and secretaries, and dilemmas in the patient-provider relation by nurses, nurses’ aides, and secretaries. Organizational and communication dilemmas reported by nurses, nurses’ aides, and secretaries often had their cause outside the control of the individual professional. These dilemmas were often “caused” by other group members (general practitioners or nurses), e.g., by not keeping appointment times or by not sharing information with patients. The implication for computer-supported cooperative health care work is that computer support should be planned on two levels. Collective work activity as a whole should benefit from individual clinical decision support for general practitioners and nurses. However, since most patient communication and organizational problems occurred at group level, group process support is required in these areas.

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