Sequence, Haplotype, and Ancestry: Using the Mitochondrial DNA Hypervariable Region to Predict Forensic “Race”

2014 ◽  
pp. 308-329
Keyword(s):  
Mitochondrial Dna ◽  
Hypervariable Region

Nucleotide sequence analysis of the hypervariable region III of mitochondrial DNA in Thais

2016 ◽  
Vol 41 ◽  
pp. 10-14 ◽  
Author(s):  
Punlop Thongngam ◽  
Worraanong Leewattanapasuk ◽  
Tanin Bhoopat ◽  
Padchanee Sangthong
Keyword(s):  
Mitochondrial Dna ◽  
Sequence Analysis ◽  
Nucleotide Sequence ◽  
Hypervariable Region ◽  
Nucleotide Sequence Analysis

scholarly journals Mitochondrial DNA (hypervariable region I) diversity in Basrah population – Iraq

Genomics ◽  
2020 ◽  
Vol 112 (5) ◽  
pp. 3560-3564 ◽  
Author(s):  
Bassim Muften Ohied ◽  
Adnan Issa Al-Badran
Keyword(s):  
Mitochondrial Dna ◽  
Hypervariable Region ◽  
Region I ◽  
Hypervariable Region I

Mitochondrial DNA variation and matrilineal structure in blue sheep populations of Helan Mountain, China

2006 ◽  
Vol 84 (10) ◽  
pp. 1431-1439 ◽  
Author(s):  
Xiao-Ming Wang ◽  
Li-Rong Cao ◽  
Zhen-Sheng Liu ◽  
Sheng-Guo Fang
Keyword(s):  
Mitochondrial Dna ◽  
Control Region ◽  
Nature Reserve ◽  
Isolation By Distance ◽  
Management Strategies ◽  
Haplotype Diversity ◽  
Hypervariable Region ◽  
Population History ◽  
Blue Sheep ◽  
Helan Mountain

Mitochondrial DNA (mtDNA) control region (5′ hypervariable region, 554 bp) sequences from 71 samples of blue sheep ( Pseudois nayaur Hodgson, 1833) collected from six study localities throughout Helan Mountain Nature Reserve in Ningxia province of China were investigated to analyse distribution patterns of genetic variability, elucidate matrilineal structure, and investigate population history. Haplotype diversity (h) among the 71 samples was estimated to be 0.792 ± 0.037, and nucleotide diversity (Π) was relatively low (0.00392 ± 0.00046). A χ2 contingency analysis of all mtDNA haplotype frequencies revealed that these haplotypes were distributed in a nonrandom fashion among study localities (χ2 = 86.205, P = 0.092). Additional evidence of matrilineal structure was provided by the finding that a significant amount (9.02%; P < 0.01) of mtDNA variation was partitioned among different localities in the study area. We conclude that blue sheep of Helan Mountain Nature Reserve are structured spatially along matrilines. Pairwise computations of Φst and an AMOVA indicated that some sampling localities are differentiated relative to a random collection of genotypes and reflected differences in the spatial distribution of genetic variation. Isolation-by-distance (IBD) models (Mantel tests) revealed no obvious association between genetic differentiation and geographical distance. These results could be a basis for the development of suitable management strategies for conservation purposes. This work represents the first analysis of blue sheep mitochondrial control region DNA to be performed from a population genetics perspective.

scholarly journals Mitochondrial DNA hypervariable region 1 diversity in Nigerian goats – CORRIGENDUM

2017 ◽  
pp. 1
Author(s):  
Moses Okpeku ◽  
Sunday O. Peters ◽  
Ikhide G. Imumorin ◽  
Kyle C. Caires ◽  
Varun K. Sharma ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Hypervariable Region ◽  
Hypervariable Region 1

Mitochondrial DNA hypervariable region-1 sequence variation and phylogeny of the concolor gibbons,Nomascus

2007 ◽  
Vol 69 (11) ◽  
pp. 1285-1306 ◽  
Author(s):  
Keri Monda ◽  
Rachel E. Simmons ◽  
Philipp Kressirer ◽  
Bing Su ◽  
David S. Woodruff
Keyword(s):  
Mitochondrial Dna ◽  
Sequence Variation ◽  
Hypervariable Region ◽  
Hypervariable Region 1

A new polymorphic positions discovered in mitochondrial DNA hypervariable region HVIII from central and north-central of Iraq

2015 ◽  
Vol 27 (5) ◽  
pp. 3250-3254 ◽  
Author(s):  
Muhanned Abdulhassan Kareem ◽  
Ameer Ibrahim Abdulzahra ◽  
Imad Hadi Hameed ◽  
Mohammed Abdullah Jebor
Keyword(s):  
Mitochondrial Dna ◽  
Hypervariable Region ◽  
North Central

scholarly journals Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness

2021 ◽  
Author(s):  
Elena Arance ◽  
Viviana Ramírez ◽  
Alejandro Rubio-Roldan ◽  
Francisco M. Ocaña-Peinado ◽  
Catalina Romero-Cachinero ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Hypervariable Region ◽  
Digital Pcr ◽  
Complex Iii ◽  
Mtdna Copy Number ◽  
Non Invasive ◽  
Apocytochrome B ◽  
Cancer Aggressiveness ◽  
Next Generation Sequencing Ngs ◽  
First Time

Abstract Background: Components of liquid biopsy are promising non-invasive biomarkers for monitoring the renal cell carcinoma (RCC) status. Present study tries to evaluate the role of exosomes and mitochondrial DNA (mtDNA) as promise, novel and stable biomarkers that could improve current ones in RCC. Methods: A total of 140 fractions obtained by ultracentrifugations of whole blood samples stored in EDTA anticoagulant from 28 (13 patients and 15 controls) were included in present study. An exosome collection protocol and exhaustive analysis of all phases obtained by ultracentrifugations (named from B to F) was performed. Subsequently, an analysis of dPCR (digital PCR) using the QuantStudio™ 3D Digital PCR platform and the quantification of mtDNA copy number using by QuantStudioTM 12K Flex Real-Time PCR System (qPCR) was developed. Moreover, Next Generation Sequencing (NGS) analyses were included using MiSeq system (Illumina, CA, USA). Results: F fraction, which contains all exosomes´ data and all mitochondrial markers (hypervariable region 1 (HV1) and apocytochrome b of complex III (MT-CYB)) were statistically identified in dPCR and qPCR (p values < 0.05) when a comparison between cases and controls was performed. Moreover, the studied mitochondrial genes shown a relevant significance in RCC aggressiveness analyses (metastasis and stages 4).Conclusions: To sum up, this is the first time a relation between mtDNA genetic markers in exosome and clinical management of RCC is suggested.

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