Structural and Dynamical Hierarchy of Fibrillar Collagen

2014 ◽  
pp. 118-135 ◽  
Keyword(s):  
Fibrillar Collagen

Production and Analysis of High Resolution Polymer Replicas of Fibrillar Collagen

1999 ◽  
Vol 5 (S2) ◽  
pp. 398-399
Author(s):  
P. Sims ◽  
B. Todd ◽  
S. Eppell ◽  
T. Li ◽  
K. Park ◽  
...  
Keyword(s):  
Cellular Response ◽  
Physical Nature ◽  
Cell Types ◽  
Artificial Substrates ◽  
Adherent Cell ◽  
Fibrillar Collagen ◽  
New Materials ◽  
Substrate Interactions ◽  
Number Of Factors ◽  
Cell Substrate

Adherent cells generally construct the immediate substrate upon which they reside. This may occur via synthesis and secretion of new materials and/or by rearrangement and modification of existing substrate. The response of adherent cell types to an existing substrate can be influenced by a number of factors which include both the chemical and physical nature of the substrate. Cell adhesion, proliferation, differentiation and death can all be substrate dependent. Much effort has been directed toward chemical modification of substrates to regulate one or more of the parameters noted above. A significant, but somewhat smaller, degree of attention has been paid to the effects of the topography and microtopography on the cell response to substrate materials. Studies to date strongly suggest the topography is a significant factor in cell-substrate interactions. As noted above, it is most probable that both the chemistry and the structure of a substrate simultaneously influence the cellular response. However we wished to determine, particularly for artificial substrates, the role which microtopography can play in cell-substrate interactions.

scholarly journals Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII α1 Chain

2015 ◽  
Vol 97 (6) ◽  
pp. 878-885 ◽  
Author(s):  
Clare V. Logan ◽  
Judith Cossins ◽  
Pedro M. Rodríguez Cruz ◽  
David A. Parry ◽  
Susan Maxwell ◽  
...  
Keyword(s):  
Collagen Type ◽  
Congenital Myasthenic Syndrome ◽  
Syndrome Type ◽  
Fibrillar Collagen ◽  
Myasthenic Syndrome

Influence of surface pretreatment of titanium- and cobalt-based biomaterials on covalent immobilization of fibrillar collagen

Biomaterials ◽  
2006 ◽  
Vol 27 (22) ◽  
pp. 4059-4068 ◽  
Author(s):  
Rainer Müller ◽  
Jochen Abke ◽  
Edith Schnell ◽  
Dieter Scharnweber ◽  
Richard Kujat ◽  
...  
Keyword(s):  
Covalent Immobilization ◽  
Fibrillar Collagen ◽  
Surface Pretreatment

Fibrillar Collagen Genes.

1990 ◽  
Vol 580 (1 Structure, Mo) ◽  
pp. 74-80 ◽  
Author(s):  
FRANCESCO RAMIREZ ◽  
SHARON BOAST ◽  
MARINA D'ALESSIO ◽  
BRENDAN LEE ◽  
JAMES PRINCE ◽  
...  
Keyword(s):  
Fibrillar Collagen ◽  
Collagen Genes

Molecular Biology of the Human Fibrillar Collagen Genes

1988 ◽  
Vol 543 (1 Third Interna) ◽  
pp. 109-116 ◽  
Author(s):  
FRANCESCO RAMIREZ ◽  
WOUTER WET
Keyword(s):  
Molecular Biology ◽  
Fibrillar Collagen ◽  
Collagen Genes

scholarly journals Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel

2019 ◽  
Vol 83 ◽  
pp. 221-232 ◽  
Author(s):  
Chun Liu ◽  
Benjamin Chiang ◽  
Daniela Lewin Mejia ◽  
Kathryn E. Luker ◽  
Gary D. Luker ◽  
...  
Keyword(s):  
Fibrillar Collagen ◽  
Nanocomposite Hydrogel

Collagen Phagocytosis by Fibroblasts in the Periodontal Ligament of the Mouse Molar During the Initial Phase of Hypofunction

1987 ◽  
Vol 66 (12) ◽  
pp. 1708-1712 ◽  
Author(s):  
W. Beertsen
Keyword(s):  
Electron Microscopy ◽  
Morphometric Analysis ◽  
Extracellular Space ◽  
Periodontal Ligament ◽  
Initial Phase ◽  
Volume Density ◽  
Collagen Fibrils ◽  
Fibrillar Collagen ◽  
Collagen Phagocytosis

This study was undertaken in order to determine whether hypofunction of teeth is associated with changes in collagen phagocytosis by fibroblasts of the periodontal ligament. In mice, the lower right molars were extracted and the animals killed one, two, three, four, or seven days later. The maxillary first molars with their surrounding periodontium were processed for electron microscopy and their periodontal ligament subjected to morphometric analysis. It was observed that, whereas the volume density of extracellular collagen in the ligament of the hypofunctional molars decreased from 50% to 30% during the course of the experiment the fraction of fibrillar collagen ingested by the cells increased over two-fold. This increase was already manifest very shortly after the onset of the experiment and offers an explanation for the net loss of collagen fibrils from the extracellular space.

scholarly journals An In Vitro Model for Assessing Corneal Keratocyte Spreading and Migration on Aligned Fibrillar Collagen

2018 ◽  
Vol 9 (4) ◽  
pp. 54 ◽  
Author(s):  
Pouriska Kivanany ◽  
Kyle Grose ◽  
Nihan Yonet-Tanyeri ◽  
Sujal Manohar ◽  
Yukta Sunkara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Cell Movement ◽  
Time Lapse ◽  
Collagen Fibrils ◽  
Fibrillar Collagen ◽  
Freeze Injury

Background: Corneal stromal cells (keratocytes) are responsible for developing and maintaining normal corneal structure and transparency, and for repairing the tissue after injury. Corneal keratocytes reside between highly aligned collagen lamellae in vivo. In addition to growth factors and other soluble biochemical factors, feedback from the extracellular matrix (ECM) itself has been shown to modulate corneal keratocyte behavior. Methods: In this study, we fabricate aligned collagen substrates using a microfluidics approach and assess their impact on corneal keratocyte morphology, cytoskeletal organization, and patterning after stimulation with platelet derived growth factor (PDGF) or transforming growth factor beta 1 (TGFβ). We also use time-lapse imaging to visualize the dynamic interactions between cells and fibrillar collagen during wound repopulation following an in vitro freeze injury. Results: Significant co-alignment between keratocytes and aligned collagen fibrils was detected, and the degree of cell/ECM co-alignment further increased in the presence of PDGF or TGFβ. Freeze injury produced an area of cell death without disrupting the collagen. High magnification, time-lapse differential interference contrast (DIC) imaging allowed cell movement and subcellular interactions with the underlying collagen fibrils to be directly visualized. Conclusions: With continued development, this experimental model could be an important tool for accessing how the integration of multiple biophysical and biochemical signals regulate corneal keratocyte differentiation.

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