scholarly journals META-ANALYSES OF THE RELATION BETWEEN SILICONE BREAST IMPLANTS AND THE RISK OF CONNECTIVE-TISSUE DISEASES

2014 ◽  
pp. 177-182
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Breast Implants ◽  
Silicone Breast Implants ◽  
Meta Analyses

Silicone Breast Implants and the Risk of Connective-Tissue Diseases and Symptoms

1995 ◽  
Vol 332 (25) ◽  
pp. 1666-1670 ◽  
Author(s):  
Jorge Sánchez-Guerrero ◽  
Graham A. Colditz ◽  
Elizabeth W. Karlson ◽  
David J. Hunter ◽  
Frank E. Speizer ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Breast Implants ◽  
Silicone Breast Implants

scholarly journals Silicone Breast Implants, Breast Cancer and Specific Connective Tissue Diseases: A Systematic Review of the Data in the Epidemiological Literature

1998 ◽  
Vol 17 (4) ◽  
pp. 497-527 ◽  
Author(s):  
Steven H. Lamm
Keyword(s):  
Breast Cancer ◽  
Connective Tissue ◽  
Cohort Studies ◽  
Lupus Erythematosus ◽  
Connective Tissue Diseases ◽  
Significant Risk ◽  
Breast Implants ◽  
Epidemiological Studies ◽  
Case Control Studies ◽  
Silicone Breast Implants

Unanswered concerns about the systemic safety of silicone breast implants (BI) underlay the Food and Drug Administration's moratorium pronouncement in 1992. Since then, many epidemiological studies have been reported that examined either the association between BI and cancer, particularly breast cancer, or the association between BI and connective tissue diseases (CTD), particularly scleroderma. These studies are reviewed, and their data are synthesized. Three breast cancer easel control studies that examine BI as a risk factor show no association between BI and breast cancer. Nor do four BI cohort studies. The data appear to show a reduced risk. No association has been seen between Bl and either breast sarcomas or total cancers. Case-control studies do not show an association between BI and scleroderma (four studies), rheumatoid arthritis (three studies), systemic lupus erythematosus (two studies), or other connective tissue diseases. Eight cohort studies of women with breast implants sought an association between BI and CTD. Seven had negative results. One found a statistically significant risk of self-reported CTD of 1.24 (upper confidence limit = 1.41), but medical record review for diagnostic confirmation has not yet been performed. In toto, the epidemiological studies do not indicate an association between breast implants and breast cancer, though they suggest possibly a negative association. In toto, the epidemiological studies do not indicate an association between breast implants and specific connective tissue diseases, though one study's current results present a small statistically significant association with self-reported CTD.

scholarly journals Silicone breast implants and connective tissue diseases

BMJ ◽  
1994 ◽  
Vol 309 (6958) ◽  
pp. 822-823 ◽  
Author(s):  
J Sanchez-Guerrero ◽  
M H Liang
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Breast Implants ◽  
Silicone Breast Implants

scholarly journals Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Yamen Homsi ◽  
John Andrew Carlson ◽  
Samer Homsi
Keyword(s):  
Connective Tissue ◽  
Immunosuppressive Therapy ◽  
Polyarteritis Nodosa ◽  
Breast Lesion ◽  
Connective Tissue Diseases ◽  
Breast Implants ◽  
Silicone Implants ◽  
Necrotizing Vasculitis ◽  
Silicone Breast Implants ◽  
The Relationship

Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis of small and medium sized arteries. We report a case of a 49-year old woman who presented with PAN following exposure to silicone breast implants. Although the relationship between silicone implants and connective tissue diseases has been investigated in the literature, no prior reports were found documenting PAN after silicone mammoplasty. While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. More robust research is needed to understand the connection between silicone breast implants and autoimmunity.

Sign in / Sign up

Export Citation Format

Share Document