Surface Modification of Biomaterials at the Nanoscale: Biomimetic Scaffolds for Tissue Engineering Applications

2014 ◽  
pp. 191-226 ◽  
Author(s):  
Duron Lee ◽  
Keshia Ashe ◽  
Cato Laurencin
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Engineering Applications ◽  
Biomimetic Scaffolds

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

Chitosan in Surface Modification for Bone Tissue Engineering Applications

2019 ◽  
Vol 14 (12) ◽  
pp. 1900171 ◽  
Author(s):  
Balakrishnan Abinaya ◽  
Tandiakkal Prakash Prasith ◽  
Badrinath Ashwin ◽  
Syamala Viji Chandran ◽  
Nagarajan Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

Laser surface modification of poly(ε-caprolactone) (PCL) membrane for tissue engineering applications

Biomaterials ◽  
2005 ◽  
Vol 26 (7) ◽  
pp. 763-769 ◽  
Author(s):  
K.S. Tiaw ◽  
S.W. Goh ◽  
M. Hong ◽  
Z. Wang ◽  
B. Lan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Laser Surface ◽  
Engineering Applications ◽  
Laser Surface Modification

scholarly journals Argon and Argon–Oxygen Plasma Surface Modification of Gelatin Nanofibers for Tissue Engineering Applications

Membranes ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 31
Author(s):  
Abolfazl Mozaffari ◽  
Mazeyar Parvinzadeh Gashti ◽  
Mohammad Mirjalili ◽  
Masoud Parsania
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Plasma Treatment ◽  
Ftir Spectroscopy ◽  
Oxygen Plasma ◽  
Attenuated Total Reflection ◽  
Oxygen Plasma Treatment ◽  
Engineering Applications ◽  
Plasma Surface Modification ◽  
Plasma Surface

In the present study, we developed a novel approach for functionalization of gelatin nanofibers using the plasma method for tissue engineering applications. For this purpose, tannic acid-crosslinked gelatin nanofibers were fabricated with electrospinning, followed by treatment with argon and argon–oxygen plasmas in a vacuum chamber. Samples were evaluated by using scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, contact angle (CA) and X-ray diffraction (XRD). The biological activity of plasma treated gelatin nanofibers were further investigated by using fibroblasts as cell models. SEM studies showed that the average diameter and the surface morphology of nanofibers did not change after plasma treatment. However, the mean surface roughness (RMS) of samples were increased due to plasma activation. ATR-FTIR spectroscopy demonstrated several new bands on plasma treated fibers related to the plasma ionization of nanofibers. The CA test results stated that the surface of nanofibers became completely hydrophilic after argon–oxygen plasma treatment. Finally, increasing the polarity of crosslinked gelatin after plasma treatment resulted in an increase of the number of fibroblast cells. Overall, results expressed that our developed method could open new insights into the application of the plasma process for functionalization of biomedical scaffolds. Moreover, the cooperative interplay between gelatin biomaterials and argon/argon–oxygen plasmas discovered a key composition showing promising biocompatibility towards biological cells. Therefore, we strongly recommend plasma surface modification of nanofiber scaffolds as a pretreatment process for tissue engineering applications.

scholarly journals Correction: Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

2015 ◽  
Vol 44 (15) ◽  
pp. 5745-5745 ◽  
Author(s):  
Xiangkui Ren ◽  
Yakai Feng ◽  
Jintang Guo ◽  
Haixia Wang ◽  
Qian Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Engineering Applications

Correction for ‘Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications’ by Xiangkui Ren et al., Chem. Soc. Rev., 2015, DOI: 10.1039/c4cs00483c.

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