Autof luorescence Diagnostics of Ophthalmic Diseases

Clinical Application and Efficacy of Silver Drug in Ophthalmology: A Literature Review and New Formulation of EYE Drops with Drug Silver (I) Complex of Metronidazole with Improved Dosage Form

Biomedicines ◽

10.3390/biomedicines9020210 ◽

2021 ◽

Vol 9 (2) ◽

pp. 210

Author(s):

Arleta Waszczykowska ◽

Dominik Żyro ◽

Justyn Ochocki ◽

Piotr Jurowski

Keyword(s):

Dosage Form ◽

Complex Analysis ◽

Bacterial Resistance ◽

Eye Drops ◽

Ophthalmic Diseases ◽

The Stability ◽

New Formulation ◽

Additional Therapy ◽

Antibacterial Potential

The use of silver preparations in medicine is becoming increasingly popular. The basic aim of this evaluation was to review the literature on the clinical (in vivo) and antibacterial potential of silver preparations in ophthalmic diseases. The second goal was to summarize the results of experimental research on the use of silver preparations in ophthalmology. The third objective was to present a method for stabilizing eye drops containing silver (I) complex. Analysis of the pH stability of the silver (I) complex with metronidazole in the prepared dosage form (eye drops) was carried out. Most silver preparations are clinically used for topical application. Few experimental results indicate the usefulness of intraocular or systemic administration of silver (I) preparations as an alternative or additional therapy in infectious and angiogenic eye diseases. The development of a new formulation increases the stability of the dosage form. New forms of silver (I) products will certainly find application in the treatment of many ophthalmic diseases. One of the most important features of the silver (I) complex is its capacity to break down bacterial resistance. The new eye drops formula can significantly improve comfort of use. Due to their chemical nature, silver (I) compounds are difficult to stabilize, especially in the finished dosage form.

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Diagnosis of Ophthalmic Diseases in Fundus Image Using various Machine Learning Techniques

2021 6th International Conference on Communication and Electronics Systems (ICCES) ◽

10.1109/icces51350.2021.9488928 ◽

2021 ◽

Author(s):

Aasawari M. Patankar ◽

Snehal S. Thorat

Keyword(s):

Machine Learning ◽

Machine Learning Techniques ◽

Fundus Image ◽

Learning Techniques ◽

Ophthalmic Diseases

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Strategies for Gene Mapping in Inherited Ophthalmic Diseases

Asia-Pacific Journal of Ophthalmology ◽

10.1097/apo.0000000000000228 ◽

2016 ◽

Vol 5 (4) ◽

pp. 282-292

Author(s):

Sundar Srilekha ◽

Bhavna Rao ◽

Divya M. Rao ◽

D. Sudha ◽

Sathya Priya Chandrasekar ◽

...

Keyword(s):

Gene Mapping ◽

Ophthalmic Diseases

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The microbiome and ophthalmic disease

Experimental Biology and Medicine ◽

10.1177/1535370218813616 ◽

2018 ◽

Vol 244 (6) ◽

pp. 419-429 ◽

Cited By ~ 13

Author(s):

Adam D Baim ◽

Asadolah Movahedan ◽

Asim V Farooq ◽

Dimitra Skondra

Keyword(s):

Ocular Surface ◽

Open Angle Glaucoma ◽

Age Related Macular Degeneration ◽

Therapeutic Interventions ◽

Gastrointestinal Microbiota ◽

Treatment And Prevention ◽

Age Related ◽

Microbiome Research ◽

Ophthalmic Diseases ◽

Ophthalmic Disease

Progress in microbiome research has accelerated in recent years. Through the use of 16S rRNA assays and other genomic sequencing techniques, researchers have provided new insights about the communities of microorganisms that inhabit human and animal hosts. There is mounting evidence about the importance of these ‘microbiotas’ in a wide variety of disease states, suggesting potential targets for preventative and therapeutic interventions. Until recently, however, the microbiome received relatively little attention in ophthalmology. This review explores emerging research on the roles that ocular and extraocular microbiotas may play in the pathogenesis and treatment of ophthalmic diseases. These include diseases of the ocular surface as well as autoimmune uveitis, age-related macular degeneration, and primary open angle glaucoma. Many questions remain about the potential impacts of microbiome research on the diagnosis, treatment, and prevention of ophthalmic disease. In light of current findings, we suggest directions for future study as this exciting area of research continues to expand. Impact statement This review describes a growing body of research on relationships between the microbiome and eye disease. Several groups have investigated the microbiota of the ocular surface; dysregulation of this delicate ecosystem has been associated with a variety of pro-inflammatory states. Other research has explored the effects of the gastrointestinal microbiota on ophthalmic diseases. Characterizing the ways these microbiotas influence ophthalmic homeostasis and pathogenesis may lead to research on new techniques for managing ophthalmic disease.

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Associations of cardiovascular diseases and type 2 diabetes with ophthalmic diseases in a population sample over 55 years old

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2021-2886 ◽

2021 ◽

Vol 20 (7) ◽

pp. 2886

Author(s):

A. O. Direev ◽

I. V. Munts ◽

E. S. Mazurenko ◽

M. Yu. Shapkina ◽

A. N. Ryabikov ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Diseases ◽

Carotid Atherosclerosis ◽

Population Sample ◽

Age Related Macular Degeneration ◽

Hypertensive Retinopathy ◽

Multivariate Models ◽

Age Related ◽

Ophthalmic Diseases

Aim. To study associations of cardiovascular diseases and type 2 diabetes (T2D) with ophthalmic diseases in a population sample of men and women from middle to old age (Novosibirsk).Material and methods. The population cohort was initially studied in 2003-2005 (n=9360, 45-69 years old, Novosibirsk, the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) project). At the second survey (2015-2017) in a random subsample (n=1011), the following ophthalmic diseases were identified: hypertensive retinopathy (HR), diabetic retinopathy (DR), cataract, glaucoma, age-related macular degeneration (AMD), optic disc abnormalities, etc.Results. The prevalence of HR signs in persons with and without hypertension (HTN) was 81 and 46%, respectively (p<0,001). This association persisted regardless of other factors (odds ratio, 2,27 (95% confidence interval: 1,78-4,17). The prevalence of AMD, cataract and DR increased in HTN, but associations were largely explained by metabolic factors in multivariate models. People with T2D more often than without T2D had signs of DR (9,3 vs 0,4%, p<0,001), AMD (22 vs 17%, p=0,042) and glaucoma (14 vs 7%, p=0,001). Associations of T2D with DR and glaucoma persisted regardless of other factors. Individuals with carotid atherosclerosis (CA) were 1,6 times more likely to have HR than those without CA when adjusted for sex, age, and smoking (p=0,013).Conclusion. In the surveyed population sample of mainly elderly people, a number of associations between cardiometabolic and common ophthalmic diseases were revealed. The identified comorbidities may have important therapeutic and prophylactic applications in an aging population.

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Polymeric Membrane for Verteporfirin Purification

Materiale Plastice ◽

10.37358/mp.17.1.4775 ◽

2017 ◽

Vol 54 (1) ◽

pp. 14-17 ◽

Cited By ~ 1

Author(s):

Stefania Simionescu ◽

Sofia Teodorescu ◽

Rodica Mariana Ion ◽

Elena Voicila ◽

Gheorghe Nechifor

Keyword(s):

Active Substance ◽

Polymeric Membrane ◽

Basic Form ◽

Polysulfone Membrane ◽

Analytical Results ◽

Before And After ◽

Ophthalmic Diseases ◽

Tumor Types ◽

Polymer Type

Verteporfirin is the active substance of the medicine Visudyne (the basic form porphyrin of the medicine) approved and in use for ophthalmic diseases and tumor types. Because the informations from literature about degraded of this porphyrins are greatly reduced, we propose in this paper to separate the different degraded forms of this porphyrin by using polysulfone membrane polymer type. In this paper are presented some analytical results of verteporfirin before and after passing degraded form of the porphyrins over these membranes.

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Experience in the Cationorm® use in the treatment of dry eye syndrome in patients after adenoviral keratoconjunctivitis

Ophthalmology journal ◽

10.17816/ov10361-66 ◽

2017 ◽

Vol 10 (3) ◽

pp. 61-66

Author(s):

Vitaly O Sokolov ◽

Natalya V Morozova ◽

Galina V Polovinkina ◽

Mariya L Borisova ◽

Inna N Zvontsova ◽

...

Keyword(s):

Incidence Rate ◽

Dry Eye ◽

Dry Eye Syndrome ◽

Clinical Use ◽

Adenoviral Infection ◽

Saint Petersburg ◽

Ophthalmic Diseases

The dry eye syndrome ranges among widespread and persisting ophthalmic diseases. It is also called a disease of civilization. Among the causes particularly often leading to the dry eye syndrome adenoviral infection has to be listed. Over the last years, in Saint Petersburg, an increasing incidence rate of the epidemic adenoviral keratoconjunctivitis is noted, which is proceeding in severe membranous and infiltrative forms, involving the cornea. Occurring therewith secondary dry eye syndrome demands using effective medications. In the article, the experience in Cationorm® (Santen, Japan) clinical use for secondary dry eye syndrome treatment is disclosed. (For citation: Sokolov VO, Morozova NV, Polovinkina GV, et al. Experience in the Cationorm® use in the treatment of dry eye syndrome in patients after adenoviral keratoconjunctivitis. Ophthalmology Journal. 2017;10(3):61-66. doi: 10.17816/OV10361-66).

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