Berberine—Alkaloid with Broad Spectrum of Pharmacological Activities

2014 ◽  
pp. 64-78
Keyword(s):  
Broad Spectrum ◽  
Pharmacological Activities ◽  
Berberine Alkaloid

Steroidal pyrazolines as a promising scaffold in drug discovery

2020 ◽  
Vol 12 (10) ◽  
pp. 949-959
Author(s):  
Ranju Bansal ◽  
Ranjit Singh
Keyword(s):  
Drug Discovery ◽  
Broad Spectrum ◽  
Chemical Reactivity ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Review Article ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Wide Range

Steroidal pyrazolines constitute an interesting and promising scaffold for drug discovery as they display diverse chemical reactivity and a wide range of biological activities. Literature reports indicate potent anticancer potential of steroidal pyrazolines along with broad-spectrum antimicrobial activities. Strong neuroprotective effects with steroids possessing pyrazoline moiety have also been observed. Among all the therapeutically active steroidal pyrazolines, D-ring-substituted derivatives are highly potent and the least toxic. The current and futuristic research approaches in this area are focused towards the exploration of this promising scaffold to develop molecules with widespread pharmacological activities. This review article mainly covers the synthetic and pharmacological aspects of steroidal pyrazolines, which will assist the medicinal chemists working in this area in their scientific endeavors.

Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds

2020 ◽  
Vol 27 ◽  
Author(s):  
Qing-Shan Li ◽  
Bang-Nian Shen ◽  
Zhen Zhang ◽  
Ban-Feng Ruan ◽  
Shuying Luo
Keyword(s):  
Broad Spectrum ◽  
Anticancer Agents ◽  
Present Review ◽  
Pyrazole Derivatives ◽  
Anticancer Activities ◽  
Structural Units ◽  
Pharmacological Activities ◽  
The Relationship

: As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In present review, it covers the pyrazoline derivatives reported by literatures from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents that containing 2-pyrazoline scaffold.

Aryltetralin-type lignan of Podophyllum: a comprehensive review

2021 ◽  
Vol 11 ◽  
Author(s):  
Dharmendra Kumar ◽  
Mogana Rajagopal ◽  
Gabriel Akyirem Akowuah ◽  
Yong-Xin Lee ◽  
Chua Wei Chong ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Chemical Synthesis ◽  
Chemical Modification ◽  
Broad Spectrum ◽  
Anticancer Agent ◽  
Review Article ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Podophyllotoxin Derivatives

: Podophyllotoxin is a nonalkaloidtoxin aryltetralin lactone lignan, occurring naturally and extracted from the rhizomes and roots of Podophyllum species. Podophyllotoxin and its derivatives have shown to possess a broad spectrum of pharmacological activities, mainly antineoplastic and antiviral properties. Podophyllotoxin is served as a potential anticancer agent and also the precursor for the chemical synthesis of some clinically important anticancer agents.The chemical modification and pharmacological investigation of podophyllotoxin derivatives have become a concern nowadays. Research interest has been stimulated in the innovation of podophyllotoxin derivatives as the semi-synthetic anticancer agent, especially etoposide and teniposide. Podophyllotoxin and its derivatives are available in several formulations and also found to be effective in combination therapy. This review article aims to provide an overview of the role of podophyllotoxin, its mechanism of action, pharmacological activities, pharmacokinetics, available formulations, and its effects in combination therapy. This article also reviewed the biosynthesis, structure and modifications of podophyllotoxin and its derivatives as an anticancer agent.

scholarly journals Functional Studies of Plant Latex as a Rich Source of Bioactive Compounds: Focus on Proteins and Alkaloids

2021 ◽  
Vol 22 (22) ◽  
pp. 12427
Author(s):  
Joanna Gracz-Bernaciak ◽  
Oliwia Mazur ◽  
Robert Nawrot
Keyword(s):  
Plant Physiology ◽  
Broad Spectrum ◽  
Gene Editing ◽  
Defense System ◽  
Chelidonium Majus ◽  
Pharmacological Activities ◽  
General Role ◽  
Functional Studies ◽  
Crucial Part ◽  
Plant Latex

Latex, a sticky emulsion produced by specialized cells called laticifers, is a crucial part of a plant’s defense system against herbivory and pathogens. It consists of a broad spectrum of active compounds, which are beneficial not only for plants, but for human health as well, enough to mention the use of morphine or codeine from poppy latex. Here, we reviewed latex’s general role in plant physiology and the significance of particular compounds (alkaloids and proteins) to its defense system with the example of Chelidonium majus L. from the poppy family. We further attempt to present latex chemicals used so far in medicine and then focus on functional studies of proteins and other compounds with potential pharmacological activities using modern techniques such as CRISPR/Cas9 gene editing. Despite the centuries-old tradition of using latex-bearing plants in therapies, there are still a lot of promising molecules waiting to be explored.

scholarly journals A Review: Medicinally Important Nitrogen Sulphur Containing Heterocycles

2020 ◽  
Vol 14 (1) ◽  
pp. 49-64
Author(s):  
Praveen K. Sharma ◽  
Andleeb Amin ◽  
M. Kumar
Keyword(s):  
Broad Spectrum ◽  
Mode Of Action ◽  
Mammalian Cells ◽  
Heterocyclic Compounds ◽  
Structural Features ◽  
Present Review ◽  
Pharmacological Activities ◽  
Sulfur Heterocycles ◽  
Biological And Pharmacological Activities

Nitrogen sulphur containing heterocycles have specific properties due to which they can be used as a potential material in a different type of industries such as medicinal/pharmaceutical, paint, packing and textile, required for various chemical, physical operations and their use as products. Especially dyes, paint, agrochemicals, medicine, etc. make them more significant. In present days, Nitrogen-Sulfur heterocycles are repeatedly attracting the interest of chemists due to their exceptional bioactive behavior. The present study is a review of the work carried out by a chemist in the discovery of new, effective, medicinally important heterocyclic compounds. The present review basically focused on nitrogen-sulfur heterocycles of potential therapeutic interest, especially with thiazole, thiazine, pyrimidine, morpholine and piperazine heterosystems, benzothiazines, pyrazole-benzothiazines, morpholine-benzothiazines, piperazine-benzothiazines and pyrimidine-benzothiazoles, mainly due to their unique structural features, which enable them to exhibit a number of biological and pharmacological activities. Due to a novel mode of action, a broad spectrum of activity, lesser toxicity towards mammalian cells, and suitable profiles towards humans have triggered the use of Nitrogen Sulphur containing heterocycles in designing and synthesizing their derivatives with better properties. The overall objective of the review is to discuss the importance of novel biodynamic structurally diverse heterocycles of potential therapeutic interest: pyrimidine, morpholine, piperazine, pyrozole, benothiazoles, pyrimidobenzothiazoles, 4H-1,4-benzothiazines, pyrazolyl-benzothiazines, morpholinyl-benzothiazines and piperazinylbenzothiazines in order to have access to important commercial molecules for the search of better future.

scholarly journals Bioactive Compounds and Health Benefits ofArtemisiaSpecies

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1985035 ◽  
Author(s):  
Manisha Nigam ◽  
Maria Atanassova ◽  
Abhay P. Mishra ◽  
Raffaele Pezzani ◽  
Hari Prasad Devkota ◽  
...  
Keyword(s):  
Free Radicals ◽  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Health Benefits ◽  
General Information ◽  
Pharmacological Activities ◽  
Ancient Times ◽  
Cancer Inflammation

Artemisia L. is a genus of small herbs and shrubs found in northern temperate regions. It belongs to the important family Asteraceae, one of the most numerous plant groupings, which comprises about 1000 genera and over 20000 species. Artemisia has a broad spectrum of bioactivity, owing to the presence of several active ingredients or secondary metabolites, which work through various modes of action. It has widespread pharmacological activities and has been used as traditional medicine since ancient times as an anthelmintic, antispasmodic, antirheumatic, and antibacterial agent and for the treatment of malaria, hepatitis, cancer, inflammation, and menstrual-related disorders. This review comprises the updated information about the ethnomedical uses and health benefits of various Artemisia spp. and general information about bioactive compounds and free radicals.

A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Saurabh Mittal ◽  
Mohammad Kashif Iqubal ◽  
Babar Iqbal ◽  
Madan Mohan Gupta ◽  
Javed Ali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antioxidant Activity ◽  
Natural Products ◽  
Neurodegenerative Disease ◽  
Broad Spectrum ◽  
Therapeutic Application ◽  
Pharmacological Activities ◽  
Bioavailability Enhancement ◽  
Prevention And Treatment ◽  
Novel Drug

AbstractNatural products are increasing used in preventing and treating various diseases. Mangiferin belongs to the xanthone family, and has potential antiangiogenic, anticancer, immunomodulatory and anti-inflammatory activity along with the antioxidant activity. It is also used in the treatment of cardiac problem, diabetes and neurodegenerative disease. Finding of various researchers proves that mangiferin has a broad spectrum therapeutic application. Motive of this review is to describe the various studies performed on mangiferin for its different pharmacological activities. It also discusses various challenges associated with mangiferin such as stability and bioavailability. Strategies and approaches to improve bioavailability of mangiferin have also been discussed. Both research and review articles were used to write the manuscript. They were collected from various search engines like Pub Med, Science Direct and Google Scholar, using keywords like mangiferin, polyphenol, bioavailability enhancement, solubility enhancement, and antioxidant. Mangiferin being a potent antioxidant is effective in the treatment of various diseases. With novel drug delivery approaches we can overcome poor solubility and bioavailability problem which eventually can result to better utilisation of mangiferin in treating a variety of diseases and make mangiferin a revolutionary drug.

scholarly journals Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

2021 ◽  
Vol 22 (2) ◽  
pp. 634
Author(s):  
Giuseppe Venturella ◽  
Valeria Ferraro ◽  
Fortunato Cirlincione ◽  
Maria Letizia Gargano
Keyword(s):  
Clinical Trials ◽  
Bioactive Compounds ◽  
Broad Spectrum ◽  
Scientific Community ◽  
Genetic Purity ◽  
Pharmacological Activities ◽  
Medicinal Mushrooms ◽  
Important Health

Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical studies are reported in this review. Besides, we analyzed the therapeutic use and pharmacological activities of mushrooms.

scholarly journals Tumbuhan Duku: Senyawa Bioaktif, Aktivitas Farmaklogis dan Prospeknya dalam Bidang Kesehatan

2018 ◽  
Vol 5 (2) ◽  
pp. 84-93
Author(s):  
Laila Hanum ◽  
Rina S. Kasiamdari
Keyword(s):  
Key Words ◽  
Bioactive Compounds ◽  
Broad Spectrum ◽  
Medical Application ◽  
Pharmacological Activities ◽  
Tropical Plant ◽  
Fruit Skin ◽  
Potential Sources ◽  
Antioxidative Stress ◽  
Lansium Domesticum

Lansium domesticum Corr. (Meliaceae) is the popular tropical plant producing economic edible fruits found mainly in Southeast Asia. Seed, leaf, bark, stalks and fruit skin extracts of this plant are potential sources for compounds with broad spectrum of pharmacological activities such as antitumor, anticancer, antimalaria, antimelanogenesis, antibacteria and it may lead to the discovery of a new compouds used for antimutagenic and antioxidative stress. Bioactive compounds, pharmacological activities and prospect this plant in medical application will be discussed in this paper. Key words: Lansium domesticum, bioactive compounds, pharmacological activities, medical application. 

scholarly journals Synthetic Transformations and Medicinal Significance of 1,2,3-Thiadiazoles Derivatives: An Update

2021 ◽  
Vol 11 (12) ◽  
pp. 5742
Author(s):  
Ali Irfan ◽  
Sami Ullah ◽  
Ayesha Anum ◽  
Nazish Jabeen ◽  
Ameer Fawad Zahoor ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Review Article ◽  
Present Review ◽  
Hybrid Structures ◽  
Activity Relationship ◽  
Pharmacological Activities ◽  
Structure Activity ◽  
Synthetic Transformations

The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid structures showed myriad biomedical activities such as antifungal, antiviral, insecticidal, antiamoebic, anticancer and plant activators, etc. In the present review, various synthetic transformations and approaches are highlighted to furnish 1,2,3-thiadiazole scaffolds along with different pharmaceutical and pharmacological activities by virtue of the presence of the 1,2,3-thiadiazole framework on the basis of structure–activity relationship (SAR). The discussion in this review article will attract the attention of synthetic and medicinal researchers to explore 1,2,3-thiadiazole structural motifs for future therapeutic agents.

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