Heuristic Modelling Applied to Epidermal Homeostasis

2016 ◽  
pp. 485-548
Keyword(s):  
Epidermal Homeostasis

scholarly journals Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling

2011 ◽  
Vol 131 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Anandaroop Mukhopadhyay ◽  
Suguna R. Krishnaswami ◽  
Benjamin D.-Y. Yu
Keyword(s):  
Mouse Skin ◽  
Epidermal Homeostasis

scholarly journals Do DLX3 and CD271 Protect Human Keratinocytes from Squamous Tumor Development?

2019 ◽  
Vol 20 (14) ◽  
pp. 3541 ◽  
Author(s):  
Elisabetta Palazzo ◽  
Alessandra Marconi ◽  
Carlo Pincelli ◽  
Maria I. Morasso
Keyword(s):  
Tumor Development ◽  
Human Keratinocytes ◽  
Epidermal Differentiation ◽  
Trk Receptor ◽  
Neurotrophin 3 ◽  
Homeobox Transcription Factor ◽  
Epidermal Homeostasis ◽  
Transcription Regulators ◽  
And Function ◽  
Normal Epidermis

Well-regulated epidermal homeostasis depends on the function of different classes of factors, such as transcription regulators and receptors. Alterations in this homeostatic balance may lead to the development of cutaneous squamous tumorigenesis. The homeobox transcription factor DLX3 is determinant for a p53-dependent regulation of epidermal differentiation and modulates skin carcinogenesis. The maintenance of skin homeostasis also involves the action of neurotrophins (NTs) and their receptors, Trk and CD271. While Trk receptor overexpression is a hallmark of cancer, there are conflicting data on CD271 expression and function in cutaneous SCC (cSCC). Previous studies have reported NT receptors expression in head and neck SSC (HNSCC). We show that CD271 is expressed at low levels in primary cSCC cells and the number of CD271+ cells correlates with cell cohesion in SCC spheroids. In normal epidermis, CD271 is expressed in proliferative progenitor cells and DLX3 in terminally differentiated keratinocytes. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) increase DLX3 expression. In the absence of a functional BDNF receptor TrkB in keratinocytes, we hypothesize that the BDNF-dependent DLX3 response could be mediated via CD271. Altogether, our results support a putative CD271-DLX3 connection in keratinocytes, which might be crucial to preventing squamous skin cancer.

The hSkn-1a POU transcription factor enhances epidermal stratification by promoting keratinocyte proliferation

2001 ◽  
Vol 114 (10) ◽  
pp. 1913-1923 ◽  
Author(s):  
J. Hildesheim ◽  
U. Kuhn ◽  
C.L. Yee ◽  
R.A. Foster ◽  
K.B. Yancey ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Keratinocytes ◽  
Dominant Negative ◽  
Keratinocyte Differentiation ◽  
Transactivation Domain ◽  
Hacat Keratinocytes ◽  
Primary Human Keratinocytes ◽  
Keratinocyte Proliferation ◽  
Proliferation And Differentiation ◽  
Epidermal Homeostasis

Skn-1a is a POU transcription factor that is primarily expressed in the epidermis and is known to modulate the expression of several genes associated with keratinocyte differentiation. However, the formation of a stratified epidermis requires a carefully controlled balance between keratinocyte proliferation and differentiation, and a role for Skn-1a in this process has not been previously demonstrated. Here, our results show, surprisingly, that human Skn-1a contributes to epidermal stratification by primarily promoting keratinocyte proliferation and secondarily by enhancing the subsequent keratinocyte differentiation. In organotypic raft cultures of both primary human keratinocytes and immortalized HaCaT keratinocytes, human Skn-1a expression is associated with increased keratinocyte proliferation and re-epithelialization of the dermal substrates, resulting in increased numbers of keratinocytes available for the differentiation process. In these same raft cultures, human Skn-1a expression enhances the phenotypic changes of keratinocyte differentiation and the upregulated expression of keratinocyte differentiation genes. Conversely, expression of a dominant negative human Skn-1a transcription factor lacking the C-terminal transactivation domain blocks keratinocytes from proliferating and stratifying. Keratinocyte stratification is dependent on a precise balance between keratinocyte proliferation and differentiation, and our results suggest that human Skn-1a has an important role in maintaining epidermal homeostasis by promoting keratinocyte proliferation.

scholarly journals 207 IL-17E (IL-25) alters epidermal homeostasis in a matter distinct from IL-17A

2019 ◽  
Vol 139 (9) ◽  
pp. S250
Author(s):  
J. Borowczyk-Michalowska ◽  
C. Buerger ◽  
J. Drukala ◽  
D. Wnuk ◽  
V. Lang ◽  
...  
Keyword(s):  
Epidermal Homeostasis

scholarly journals Modeling How Epidermal Homeostasis is Achieved

2014 ◽  
Vol 106 (2) ◽  
pp. 380a
Author(s):  
Jin Seob Kim ◽  
Sean X. Sun
Keyword(s):  
Epidermal Homeostasis

scholarly journals 631 Laminin-511 is a key component of epidermal basement membrane to maintain epidermal homeostasis

2018 ◽  
Vol 138 (5) ◽  
pp. S107
Author(s):  
S. Iriyama ◽  
S. Nishikawa ◽  
E. Takai ◽  
H. Yamanishi ◽  
N. Kunizawa ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Epidermal Homeostasis ◽  
Epidermal Basement Membrane
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