PHARMACOGENETICS AND PHARMACOGENOMICS IN PERSONALIZED MEDICINE: ROLE OF GENE POLYMORPHISM IN DRUG RESPONSE

2014 ◽  
pp. 35-71
Author(s):  
Rownock Afruza ◽  
Fumiaki Suzuki ◽  
A Nabi
Keyword(s):  
Personalized Medicine ◽  
Gene Polymorphism ◽  
Drug Response

scholarly journals The Role of Network Science in Glioblastoma

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1045
Author(s):  
Marta B. Lopes ◽  
Eduarda P. Martins ◽  
Susana Vinga ◽  
Bruno M. Costa
Keyword(s):  
Personalized Medicine ◽  
Drug Development ◽  
Information Flow ◽  
Clinical Studies ◽  
Network Science ◽  
Cancer Genomics ◽  
High Dimensional ◽  
Network Discovery ◽  
Software Implementations

Network science has long been recognized as a well-established discipline across many biological domains. In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. Glioblastoma (GBM) is an example of such a complex and heterogeneous disease that can be tackled by network science. Identifying the architecture of molecular GBM networks is essential to understanding the information flow and better informing drug development and pre-clinical studies. Here, we review network-based strategies that have been used in the study of GBM, along with the available software implementations for reproducibility and further testing on newly coming datasets. Promising results have been obtained from both bulk and single-cell GBM data, placing network discovery at the forefront of developing a molecularly-informed-based personalized medicine.

scholarly journals Role of toll like receptor-9 (1237 T/C) gene polymorphism in patients with type 2 diabetes and diabetic foot ulcer

2021 ◽  
Vol 1879 (2) ◽  
pp. 022012
Author(s):  
Furqan Naeem Al-Karawi ◽  
Naji Al-Hasnawiand Abeer Thaher ◽  
Thekra Abd Jebur Al-Kashwan
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Toll Like Receptor

scholarly journals Pharmacokinetics and Pharmacodynamics of Meloxicam in East Asian Populations: The Role of Ethnicity on Drug Response

2017 ◽  
Vol 6 (12) ◽  
pp. 823-832 ◽  
Author(s):  
Takahiko Aoyama ◽  
Yoshimasa Ishida ◽  
Masato Kaneko ◽  
Aoi Miyamoto ◽  
Yoshiro Saito ◽  
...  
Keyword(s):  
Drug Response ◽  
East Asian ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Asian Populations

The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men

Urology ◽  
2015 ◽  
Vol 86 (4) ◽  
pp. 730-734
Author(s):  
Amir Fattahi ◽  
Iraj Khodadadi ◽  
Iraj Amiri ◽  
Zeinab Latifi ◽  
Marzieh Ghorbani ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Adenosine Deaminase ◽  
Infertile Men

Reaching Future Scientists, Consumers, & Citizens

2014 ◽  
Vol 76 (6) ◽  
pp. 379-383 ◽  
Author(s):  
Melissa A. Hicks ◽  
Rebecca J. Cline ◽  
Angela M. Trepanier
Keyword(s):  
Personalized Medicine ◽  
Genetic Basis ◽  
Genetic Disorders ◽  
Single Gene ◽  
Personal Health ◽  
Adult Onset ◽  
Biology Textbooks ◽  
Multifactorial Diseases ◽  
Single Gene Disorders

An understanding of how genomics information, including information about risk for common, multifactorial disease, can be used to promote personal health (personalized medicine) is becoming increasingly important for the American public. We undertook a quantitative content analysis of commonly used high school textbooks to assess how frequently the genetic basis of common multifactorial diseases was discussed compared with the “classic” chromosomal–single gene disorders historically used to teach the concepts of genetics and heredity. We also analyzed the types of conditions or traits that were discussed. We identified 3957 sentences across 11 textbooks that addressed multifactorial and “classic” genetic disorders. “Classic” gene disorders were discussed relatively more frequently than multifactorial diseases, as was their genetic basis, even after we enriched the sample to include five adult-onset conditions common in the general population. Discussions of the genetic or hereditary components of multifactorial diseases were limited, as were discussions of the environmental components of these conditions. Adult-onset multifactorial diseases are far more common in the population than chromosomal or single-gene disorders; many are potentially preventable or modifiable. As such, they are targets for personalized medical approaches. The limited discussion in biology textbooks of the genetic basis of multifactorial conditions and the role of environment in modifying genetic risk may limit the public’s understanding and use of personalized medicine.

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