Effects of intergranular adhesive force on behavior of granular material

2004 ◽  
pp. 347-354 ◽  
Author(s):  
S Kato ◽  
T Sakakibara ◽  
H Yoshimori
Keyword(s):  
Granular Material ◽  
Adhesive Force

Ultra-Rapid Freezing of Isolated Skeletal Muscle Fibers

1977 ◽  
Vol 35 ◽  
pp. 576-577
Author(s):  
Joachim R. Sommer ◽  
Nancy R. Wallace
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Granular Material ◽  
Nuclear Envelope ◽  
Intracellular Calcium ◽  
Ruthenium Red ◽  
Threshold Concentration ◽  
Rapid Freezing ◽  
Frog Skeletal Muscle ◽  
Electrical Isolation

After Howell (1) had shown that ruthenium red treatment of fixed frog skeletal muscle caused collapse of the intermediate cisternae of the sarcoplasmic reticulum (SR), forming a pentalaminate structure by obi iterating the SR lumen, we demonstrated that the phenomenon involves the entire SR including the nuclear envelope and that it also occurs after treatment with other cations, including calcium (2,3,4).From these observations we have formulated a hypothesis which states that intracellular calcium taken up by the SR at the end of contraction causes the M rete to collapse at a certain threshold concentration as the first step in a subsequent centrifugal zippering of the free SR toward the junctional SR (JSR). This would cause a) bulk transport of SR contents, such as calcium and granular material (4) into the JSR and, b) electrical isolation of the free SR from the JSR.

Effect of Some Metabolic Inhibitors on Vinblastine-Induced Ribosomal-Granular Material Complexes

1971 ◽  
Vol 29 ◽  
pp. 548-549
Author(s):  
Awtar Krishan ◽  
Dora Hsu
Keyword(s):  
Granular Material ◽  
Rna Synthesis ◽  
Culture Medium ◽  
Actinomycin D ◽  
Metabolic Inhibitors ◽  
Protein And Rna Synthesis ◽  
Apparent Reduction ◽  
Plant Alkaloids ◽  
In Cells

Cells exposed to antitumor plant alkaloids, vinblastine and vincristine sulfate have large proteinacious crystals and complexes of ribosomes, helical polyribosomes and electron-dense granular material (ribosomal complexes) in their cytoplasm, Binding of H3-colchicine by the in vivo crystals shows that they contain microtubular proteins. Association of ribosomal complexes with the crystals suggests that these structures may be interrelated.In the present study cultured human leukemic lymphoblasts (CCRF-CEM), were incubated with protein and RNA-synthesis inhibitors, p. fluorophenylalanine, puromycin, cycloheximide or actinomycin-D before the addition of crystal-inducing doses of vinblastine to the culture medium. None of these compounds could completely prevent the formation of the ribosomal complexes or the crystals. However, in cells pre-incubated with puromycin, cycloheximide, or actinomycin-D, a reduction in the number and size of the ribosomal complexes was seen. Large helical polyribosomes were absent in the ribosomal complexes of cells treated with puromycin, while in cells exposed to cycloheximide, there was an apparent reduction in the number of ribosomes associated with the ribosomal complexes (Fig. 2).

Stress fields in granular material and implications for performance of robot locomotion over granular media

2015 ◽  
Vol 8 (1) ◽  
pp. 2005-2009
Author(s):  
Diandong Ren ◽  
Lance M. Leslie ◽  
Congbin Fu
Keyword(s):  
Mechanical Properties ◽  
Granular Material ◽  
Granular Media ◽  
Rotation Frequency ◽  
Legged Locomotion ◽  
Working Environment ◽  
Navier Stokes ◽  
Maximum Speed ◽  
Sigmoid Curve ◽  
Multi Body

 Legged locomotion of robots has advantages in reducing payload in contexts such as travel over deserts or in planet surfaces. A recent study (Li et al. 2013) partially addresses this issue by examining legged locomotion over granular media (GM). However, they miss one extremely significant fact. When the robot’s wheels (legs) run over GM, the granules are set into motion. Hence, unlike the study of Li et al. (2013), the viscosity of the GM must be included to simulate the kinematic energy loss in striking and passing through the GM. Here the locomotion in their experiments is re-examined using an advanced Navier-Stokes framework with a parameterized granular viscosity. It is found that the performance efficiency of a robot, measured by the maximum speed attainable, follows a six-parameter sigmoid curve when plotted against rotating frequency. A correct scaling for the turning point of the sigmoid curve involves the footprint size, rotation frequency and weight of the robot. Our proposed granular response to a load, or the ‘influencing domain’ concept points out that there is no hydrostatic balance within granular material. The balance is a synergic action of multi-body solids. A solid (of whatever density) may stay in equilibrium at an arbitrary depth inside the GM. It is shown that there exists only a minimum set-in depth and there is no maximum or optimal depth. The set-in depth of a moving robot is a combination of its weight, footprint, thrusting/stroking frequency, surface property of the legs against GM with which it has direct contact, and internal mechanical properties of the GM. If the vehicle’s working environment is known, the wheel-granular interaction and the granular mechanical properties can be grouped together. The unitless combination of the other three can form invariants to scale the performance of various designs of wheels/legs. Wider wheel/leg widths increase the maximum achievable speed if all other parameters are unchanged.

Nanorobots Sense Local Physiochemical Heterogeneities of Tumor Matrisome

2020 ◽  
Author(s):  
Debayan Dasgupta ◽  
Dharma Pally ◽  
Deepak K. Saini ◽  
Ramray Bhat ◽  
Ambarish Ghosh
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Adhesive Force ◽  
Surrounding Tissue ◽  
Quantitative Measurements ◽  
Malignant Breast Tumor ◽  
Malignant Breast ◽  
Cancer Dissemination

The dissemination of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Understanding and quantifying the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer dissemination. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanorobots, to locally probe a 3D tissue culture microenvironment consisting of cancerous and non-cancerous epithelia, embedded within reconstituted basement membrane (rBM) matrix. Our assay is designed to mimic the in vivo histopathological milieu of a malignant breast tumor. We find that nanorobots preferentially adhere to the ECM near cancer cells: this is due to the distinct charge conditions of the cancer-remodeled ECM. Surprisingly, quantitative measurements estimate that the adhesive force increases with the metastatic ability of cancer cell lines, while the spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cancer cell lines studied here. We hypothesized and experimentally confirmed that specific sialic acid linkages specific to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. The findings reported here can lead to promising applications in cancer diagnosis, quantification of cancer aggression, in vivo drug delivery applications, and establishes the tremendous potential of magnetic nanorobots for fundamental studies of cancer biomechanics.

scholarly journals Research on the Constitutive Model for Granular Material

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Wei Zhen-hai ◽  
Wang Meng-shu ◽  
Zhang Ding-li
Keyword(s):  
Constitutive Model ◽  
Granular Material

scholarly journals Force chains in crystalline and frustrated packings of uniform spheres visualized by stress-birefringence

Soft Matter ◽  
2021 ◽  
Author(s):  
David Fischer ◽  
Ralf Stannarius ◽  
Karsten Tell ◽  
Peidong Yu ◽  
Matthias Sperl
Keyword(s):  
Granular Material ◽  
Force Chains ◽  
Force Networks ◽  
The Stability

Force networks play an important role in the stability of configurations when granular material is packed into a container. These networks can redirect part of the weight of grains inside...

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