Two Faces Of Adult Blood Vessel Formation: Vasculogenesis And Angiogenesis

2016 ◽  
pp. 112-152
Keyword(s):  
Blood Vessel ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Vasculogenesis And Angiogenesis

scholarly journals Vasculogenesis and angiogenesis in modular collagen–fibrin microtissues

2014 ◽  
Vol 2 (10) ◽  
pp. 1497-1508 ◽  
Author(s):  
A. W. Peterson ◽  
D. J. Caldwell ◽  
A. Y. Rioja ◽  
R. R. Rao ◽  
A. J. Putnam ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Vessel ◽  
Tissue Development ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Surrounding Matrix ◽  
Vasculogenesis And Angiogenesis ◽  
Vessel Networks

Vessel networks can be generated within modular protein microbeads containing endothelial cells and fibroblasts. Embedding these microtissues in a surrounding matrix emulates aspects of new blood vessel formation, a process that is critical in tissue development, remodeling, and regeneration.

scholarly journals Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels

Blood ◽  
2006 ◽  
Vol 107 (9) ◽  
pp. 3546-3554 ◽  
Author(s):  
Lorena Zentilin ◽  
Sabrina Tafuro ◽  
Serena Zacchigna ◽  
Nikola Arsic ◽  
Lucia Pattarini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blood Vessel ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
Experimental Models ◽  
Large Set ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Sprouting Angiogenesis ◽  
Vasculogenesis And Angiogenesis

Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel formation during both vasculogenesis and angiogenesis. The prolonged expression of VEGF in the normoperfused skeletal muscles of adult rodents after gene transfer using AAV vectors induces the formation of a large set of new capillaries and small arteries. Notably, this process is accompanied by the massive infiltration by mononuclear cells. This observation raises the possibility that these cells might represent circulating progenitors that are eventually incorporated in the newly formed vessels. Here we explore this possibility by exploiting 4 different experimental models based on (a) the transplantation of male bone marrow into female recipients; (b) the transplantation of Tie2-GFP transgenic bone marrow; (c) the transplantation of bone marrow in the presence of erythropoietin (EPO), a mobilizer of endothelial progenitor cells (EPCs); and (d) the reimplantation of ex vivo–expanded EPCs. In all 4 models, VEGF acted as a powerful attractor of bone marrow–derived mononuclear cells, bearing different myeloid and endothelial markers proper of the EPCs to the sites of neovascularization. In no case, however, were the attracted cells incorporated in the newly formed vasculature. These observations indicate that new blood vessel formation induced by VEGF occurs through bona fide sprouting angiogenesis; the contribution of the infiltrating bone marrow–derived cells to this process still remains enigmatic.

scholarly journals Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development

2021 ◽  
Vol 22 (6) ◽  
pp. 2804
Author(s):  
Yasuo Yoshitomi ◽  
Takayuki Ikeda ◽  
Hidehito Saito-Takatsuji ◽  
Hideto Yonekura
Keyword(s):  
Endothelial Cells ◽  
Transcription Factor ◽  
Blood Vessel ◽  
Vascular Endothelial Cells ◽  
Vascular Development ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial ◽  
Blood Vessel Formation ◽  
Vessel Formation

Blood vessels are essential for the formation and maintenance of almost all functional tissues. They play fundamental roles in the supply of oxygen and nutrition, as well as development and morphogenesis. Vascular endothelial cells are the main factor in blood vessel formation. Recently, research findings showed heterogeneity in vascular endothelial cells in different tissue/organs. Endothelial cells alter their gene expressions depending on their cell fate or angiogenic states of vascular development in normal and pathological processes. Studies on gene regulation in endothelial cells demonstrated that the activator protein 1 (AP-1) transcription factors are implicated in angiogenesis and vascular development. In particular, it has been revealed that JunB (a member of the AP-1 transcription factor family) is transiently induced in endothelial cells at the angiogenic frontier and controls them on tip cells specification during vascular development. Moreover, JunB plays a role in tissue-specific vascular maturation processes during neurovascular interaction in mouse embryonic skin and retina vasculatures. Thus, JunB appears to be a new angiogenic factor that induces endothelial cell migration and sprouting particularly in neurovascular interaction during vascular development. In this review, we discuss the recently identified role of JunB in endothelial cells and blood vessel formation.

Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs

Biomaterials ◽  
2012 ◽  
Vol 33 (7) ◽  
pp. 2097-2108 ◽  
Author(s):  
Duohong Zou ◽  
Zhiyuan Zhang ◽  
Jiacai He ◽  
Kai Zhang ◽  
Dongxia Ye ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Active Form ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Constitutively Active

scholarly journals Trans-Resveratrol Inhibits Early Blood Vessel Formation (Vasculogenesis) Without Impairment of Embryonic Growth

2008 ◽  
Vol 107 (2) ◽  
pp. 118-127 ◽  
Author(s):  
Paulo Fernando Dias ◽  
Fernanda Vieira Berti ◽  
Jarbas Mota Siqueira Jr ◽  
Marcelo Maraschin ◽  
Antônio Ricardo Gagliardi ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Blood Vessel Formation ◽  
Vessel Formation ◽  
Embryonic Growth
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