Phosphate Homeostasis and Metabolic Bone Disease

2014 ◽  
pp. 150-179
Keyword(s):  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Phosphate Homeostasis ◽  
Metabolic Bone

Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences

2019 ◽  
Vol 104 (5) ◽  
pp. F560-F566 ◽  
Author(s):  
Amish Chinoy ◽  
Mohamed Zulf Mughal ◽  
Raja Padidela
Keyword(s):  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Diuretic Therapy ◽  
Fragility Fractures ◽  
Third Trimester ◽  
Phosphate Homeostasis ◽  
Metabolic Bone ◽  
Routine Handling ◽  
Postnatal Factors

Metabolic bone disease of prematurity (MBDP) is characterised by skeletal demineralisation, and in severe cases it can result in fragility fractures of long bones and ribs during routine handling. MBDP arises from prenatal and postnatal factors. Infants who are born preterm are deprived of fetal mineral accumulation, 80% of which occurs in the third trimester. Postnatally, it is difficult to maintain a comparable intake of minerals, and medications, such as corticosteroids and diuretic therapy, lead to bone resorption. With improvements in neonatal care and nutrition, the incidence of MBDP in preterm infants appears to have decreased, although the recent practice of administering phosphate supplements alone will result in secondary hyperparathyroidism and associated bone loss, worsening MBDP. Postnatal immobilisation and loss of placental supply of oestrogen also contribute to skeletal demineralisation. There is no single diagnostic or screening test for MBDP, with pitfalls existing for most radiological and biochemical investigations. By reviewing the pathophysiology of calcium and phosphate homeostasis, one can establish that plasma parathyroid hormone is important in determining the aetiology of MBDP – primarily calcipaenia or phosphopaenia. This will then direct treatment with the appropriate supplements while considering optimal physiological calcium to phosphate ratios.

Vitamin D levels and signs of metabolic bone disease in adolescents with idiopathic scoliosis

2013 ◽  
Author(s):  
Adodra Annika ◽  
Kouklinos Andreas ◽  
Julies Priscilla ◽  
Shaw Mathew ◽  
Jacobs Benjamin
Keyword(s):  
Vitamin D ◽  
Idiopathic Scoliosis ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Metabolic Bone ◽  
Vitamin D Levels

Femoral Neck Stress Fractures and Metabolic Bone Disease

2001 ◽  
Vol 15 (3) ◽  
pp. 181-185 ◽  
Author(s):  
Michael P. Muldoon ◽  
Douglas E. Padgett ◽  
Donald E. Sweet ◽  
Patricia A. Deuster ◽  
Gregory R. Mack
Keyword(s):  
Femoral Neck ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Stress Fractures ◽  
Metabolic Bone

Metabolic bone disease

2014 ◽  
pp. 221-230
Author(s):  
Mubashshar Ahmad ◽  
Gavin De Kiewiet
Keyword(s):  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Metabolic Bone

scholarly journals A rare case of metabolic bone disease

2007 ◽  
Vol 44 (2) ◽  
pp. 192-195 ◽  
Author(s):  
Rajeev Srivastava ◽  
Fiona Jenkinson ◽  
Michael J Murphy
Keyword(s):  
Bone Disease ◽  
Rare Case ◽  
Metabolic Bone Disease ◽  
Metabolic Bone
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