ROBUST REGRESSION DESIGNS FOR NON-NORMAL DISTRIBUTIONS

2014 ◽  
pp. 77-88
Keyword(s):  
Robust Regression ◽  
Normal Distributions

Normal Distributions

1989 ◽  
Author(s):  
Teresa M. Amabile
Keyword(s):  
Normal Distributions

Distribution of in vivo insulin action in Pima Indians as mixture of three normal distributions

Diabetes ◽  
1989 ◽  
Vol 38 (11) ◽  
pp. 1423-1432 ◽  
Author(s):  
C. Bogardus ◽  
S. Lillioja ◽  
B. L. Nyomba ◽  
F. Zurlo ◽  
B. Swinburn ◽  
...  
Keyword(s):  
Insulin Action ◽  
Pima Indians ◽  
Normal Distributions

Common Genetic Variants in ABO and CLEC4M Modulate the Pharmacokinetics of Recombinant FVIII in Severe Hemophilia A Patients

2020 ◽  
Vol 120 (10) ◽  
pp. 1395-1406 ◽  
Author(s):  
Iris Garcia-Martínez ◽  
Nina Borràs ◽  
Marta Martorell ◽  
Rafael Parra ◽  
Carme Altisent ◽  
...  
Keyword(s):  
Blood Group ◽  
Half Life ◽  
Robust Regression ◽  
Hemophilia A ◽  
Illumina Miseq ◽  
Activity Levels ◽  
Severe Hemophilia ◽  
Single Nucleotide Variants ◽  
Common Genetic Variants ◽  
Recombinant Fviii

AbstractThe pharmacokinetic (PK) response of severe hemophilia A (HA) patients to infused factor VIII (FVIII) shows substantial variability. Several environmental and genetic factors are associated with changes in FVIII plasma levels and infused FVIII PK. Based on the hypothesis that factors influencing endogenous FVIII can affect FVIII PK, the contribution of single-nucleotide variants (SNVs) in candidate genes was investigated in 51 severe HA patients. The effects of blood group, F8 variant type, von Willebrand factor antigen and activity levels, age, and weight were also explored. The myPKFiT device was used to estimate individual PK parameters, and SNVs and clinically reportable F8 variants were simultaneously analyzed in an Illumina MiSeq instrument, using the microfluidics-based Fluidigm Access Array system. The contribution of SNVs to FVIII half-life and clearance was addressed by robust regression modeling, taking into account other modulators. In line with previous studies, we provide robust evidence that age, body weight, and blood group, as well as SNVs in ABO and CLEC4M, participate in the variability of FVIII PK in HA patients. Main results: each copy of the rs7853989 (ABO) allele increases FVIII half-life by 1.4 hours (p = 0.0131) and decreases clearance by 0.5 mL/h/kg (p = 5.57E-03), whereas each additional rs868875 (CLEC4M) allele reduces FVIII half-life by 1.1 hours (p = 2.90E-05) and increases clearance by 0.3 mL/h/kg (p = 1.01E-03). These results contribute to advancing efforts to improve FVIII replacement therapies by adjusting to each patient's PK profile based on pharmacogenomic data. This personalized medicine will decrease the burden of treatment and maximize the benefits obtained.

Log-normal distributions in parasitology

1984 ◽  
Vol 93 (6) ◽  
pp. 591-598 ◽  
Author(s):  
Sandeep K Malhotra
Keyword(s):  
Normal Distributions ◽  
Log Normal

scholarly journals Normal approximation for mixtures of normal distributions and the evolution of phenotypic traits

2021 ◽  
Vol 53 (1) ◽  
pp. 162-188
Author(s):  
Krzysztof Bartoszek ◽  
Torkel Erhardsson
Keyword(s):  
Normal Distribution ◽  
Phenotypic Trait ◽  
Phenotypic Traits ◽  
Normal Distributions ◽  
Average Value ◽  
Conditional Moments ◽  
Mixture Of Normal Distributions ◽  
Explicit Bounds ◽  
Mixtures Of Normal Distributions ◽  
Parameter Values

AbstractExplicit bounds are given for the Kolmogorov and Wasserstein distances between a mixture of normal distributions, by which we mean that the conditional distribution given some $\sigma$ -algebra is normal, and a normal distribution with properly chosen parameter values. The bounds depend only on the first two moments of the first two conditional moments given the $\sigma$ -algebra. The proof is based on Stein’s method. As an application, we consider the Yule–Ornstein–Uhlenbeck model, used in the field of phylogenetic comparative methods. We obtain bounds for both distances between the distribution of the average value of a phenotypic trait over n related species, and a normal distribution. The bounds imply and extend earlier limit theorems by Bartoszek and Sagitov.

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