Effect of Postnatal Growth in the Large-for-Gestational-Age Infants

2014 ◽  
pp. 136-165 ◽  
Keyword(s):  
Gestational Age ◽  
Postnatal Growth ◽  
Large For Gestational Age

scholarly journals Childhood Health Outcomes in Term, Large-for-Gestational-Age Babies With Different Postnatal Growth Patterns

2017 ◽  
Vol 187 (3) ◽  
pp. 507-514 ◽  
Author(s):  
Xiaoping Lei ◽  
Dongying Zhao ◽  
Lisu Huang ◽  
Zhongcheng Luo ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Gestational Age ◽  
Postnatal Growth ◽  
Growth Patterns ◽  
Large For Gestational Age ◽  
Childhood Health

scholarly journals Association of cord blood des-acyl ghrelin with Apgar score and anthropometric measures in relation to its maternal one.

2019 ◽  
Vol 12 (3) ◽  
pp. 1147-1154
Author(s):  
Enas R. Abdelhamid ◽  
Alyaa H. Kamhawy ◽  
Hanaa H. Ahmed ◽  
Mones M. Abu Shady ◽  
Ahmed Fathy ◽  
...  
Keyword(s):  
Cord Blood ◽  
Negative Correlation ◽  
Gestational Age ◽  
Apgar Score ◽  
Critical Role ◽  
Significant Negative Correlation ◽  
Postnatal Growth ◽  
Large For Gestational Age ◽  
Anthropometric Measures ◽  
Acyl Ghrelin

Ghrelin is a pleiotropic hormone that governs eating and energy equilibrium as well as promotes the release of growth hormone release. Although cord blood ghrelin has been correlated to the weight at birth and other anthropometric measures, the implication of des-acyl ghrelin in fetal and postnatal growth still not well understood. The goal of this research was to investigate the concentration of des-acyl ghrelin (DAG) in cord blood of appropriate for gestational age (AGA), small for gestational age (SGA) and large for gestational age (LGA) infants in order to elucidate their correlation with birth weight, anthropometric measures as well as apgar score of the newborn and relating them to maternal DAG levels. Cord blood specimens were procured from 25 SGA, 24 AGA infants and 25 LGA infants. Desacyl ghrelin, was quantified by ELIZA. A significant negative correlation has been found between cord ghrelin and neonatal anrthropometric measures( neonatal weight, height, head circumference, mean arm circumference) As well, a significant negative correlation has been detected between cord ghrelin and apgar score at 1 and 5 min. The current results shed the light on the critical role of DAG in the growth during the intrauterine period. Further studies are necessary to identify the exact mechanisms underlying the contribution of DAG in the growth of the fetus.

scholarly journals Adiponectin: serum levels, promoter polymorphism, and associations with birth size and cardiometabolic outcome in young adults born large for gestational age

2010 ◽  
Vol 162 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Ana Carolina Bueno ◽  
Aniette R Espiñeira ◽  
Fábio L Fernandes-Rosa ◽  
Roberto Molina de Souza ◽  
Margaret de Castro ◽  
...  
Keyword(s):  
Gestational Age ◽  
Regulatory Region ◽  
Adult Life ◽  
Serum Levels ◽  
Postnatal Growth ◽  
Assessment Model ◽  
Variant Allele ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Birth Size

ObjectiveTo assess whether the −11391G>A polymorphism in the regulatory region of the adiponectin gene (ADIPOQ) is associated with birth size, postnatal growth, adiponectinemia, and cardiometabolic risk in adult life.DesignCase–control study nested within a prospective cohort of 2063 community subjects born in 1978/1979 and followed since birth to date.MethodsADIPOQ −11391G>A genotype–phenotype associations were evaluated in 116 subjects born large for gestational age (LGA) and 392 gender-matched controls at birth (birth size), at 8–10 years (catch-down growth), and at 23–25 years of age (cardiometabolic profile).ResultsThe −11391A variant allele frequency was higher in LGA subjects (P=0.04). AA genotype was associated with augmented probability of being born LGA (odds ratio=4.14; 95% confidence interval: 1.16–16.7; P=0.03). This polymorphism was associated neither with body composition nor with postnatal growth pattern. At the age of 23–25 years, the −11391A variant allele was associated with higher serum adiponectin levels (GG: 10.7±6.2 versus GA: 12.2±6.5 versus AA: 14.2±6.8 μg/ml; P<0.01). Subjects born LGA presented higher body mass index (BMI; P=0.01), abdominal circumference (P=0.04), blood pressure (P=0.04), and homeostasis assessment model for insulin resistance (P=0.01) than adequate for gestational age. Symmetry at birth did not influence these variables. The occurrence of catch-down of weight was associated with lower BMI and abdominal circumference (P<0.001) at 23–25 years.ConclusionsThe −11391A ADIPOQ gene variant was associated with increased chance of being born LGA and with higher adiponectin levels in early adult life.

scholarly journals G-ROP Criteria for Predicting Retinopathy of Prematurity Among Neonates with Different Birth Weight Percentiles

2022 ◽  
Author(s):  
Asli Okbay Gunes ◽  
Sevilay Topcuoglu ◽  
Gokhan Celik ◽  
Osman Kizilay ◽  
Muhammed Ali Recai Akyurekli ◽  
...  
Keyword(s):  
Birth Weight ◽  
Sensitivity And Specificity ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Small For Gestational Age ◽  
Postnatal Growth ◽  
Large For Gestational Age ◽  
Appropriate For Gestational Age

Abstract Purpose: To determine whether being small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA) affected the sensitivity and specificity of Postnatal Growth and Retinopathy of Prematurity (G-ROP) model. Methods: We applied the G-ROP criteria, except hydrocephalus, for prematures retrospectively. The infants were divided into three subgroups according to birth weight percentiles (SGA, AGA, LGA), and the performance of the G-ROP criteria was tested for each group by calculating sensitivity and specificity for any stage retinopathy of prematurity (ROP) and severe ROP. Severe ROP was defined as ROP needing treatment. Results: Three hundred and ninety neonates screened for ROP were included. The gestational age and birth weight of the neonates were 29.3±2.9 weeks and 1302.9±416 g, respectively. There were 41 (10.5%) SGA, 312 (80%) AGA and 37 (9.5%) LGA neonates. The sensitivity of the model for any ROP was 67.8%, 66.7%, 73.2%, 55.6% for all of the patients in the study, SGA, AGA, and LGA neonates, respectively. The sensitivity of the model for severe ROP in all group and for each subgroup was 100%. The specificity of the model for any ROP was 65.9%, 70.6%, 87.7%, 90% for all of the patients, SGA, AGA, and LGA neonates, respectively. The specificity for severe ROP was 46.4%, 50%, 44%, 63.6% for all of the patients, SGA, AGA, and LGA neonates, respectively.Conclusion: The sensitivity and specificity of the G-ROP model in SGA infants were similar with the whole group, but was different between SGA, AGA and LGA neonates. Although the model did not miss any severe ROP, the specificity of the model for severe ROP was found low.

Postnatal growth and cardiometabolic profile in young adults born large for gestational age

2011 ◽  
Vol 75 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Aniette Renom Espineira ◽  
Fábio Luiz Fernandes-Rosa ◽  
Ana Carolina Bueno ◽  
Roberto Molina de Souza ◽  
Ayrton Custódio Moreira ◽  
...  
Keyword(s):  
Young Adults ◽  
Gestational Age ◽  
Postnatal Growth ◽  
Large For Gestational Age ◽  
Cardiometabolic Profile

scholarly journals Ghrelin levels are decreased in non-obese prepubertal children born large for gestational age

2009 ◽  
Vol 160 (6) ◽  
pp. 951-956 ◽  
Author(s):  
Feyza Darendeliler ◽  
Sukran Poyrazoglu ◽  
Firdevs Bas ◽  
Ozlem Sancakli ◽  
Gulbin Gokcay
Keyword(s):  
Insulin Resistance ◽  
Birth Weight ◽  
Gestational Age ◽  
Energy Homeostasis ◽  
Standard Deviation Score ◽  
Postnatal Growth ◽  
Large For Gestational Age ◽  
Model Assessment ◽  
Prepubertal Children ◽  
Increased Risk

BackgroundGhrelin is the natural ligand of GH secretagogue receptor. It has several metabolic functions including regulation of food intake, energy homeostasis, and body weight. An inverse relationship between fasting plasma ghrelin and insulin concentrations has been shown. Being born large for gestational age (LGA) has an increased risk of developing insulin resistance.ObjectiveThe aim of this study was to evaluate ghrelin levels in LGA born children who have no obesity at prepubertal ages and the effect of intrauterine and postnatal growth on ghrelin levels.Patients and methodsThirty-two (17F, 15M) LGA born non-obese children (mean (±s.e.m.) age 4.4±0.3 years) were evaluated with respect to glucose, insulin, and ghrelin levels. Their data were compared with that of non-obese 45 (19F, 26M) appropriate for gestational age (AGA) children (mean (±s.e.m.) age 4.0±0.1 years).ResultsLGA children, who had similar age and body mass index (BMI) standard deviation score (SDS) as AGA children, had significantly higher insulin (P=0.044) and at a borderline significance higher homeostasis model assessment-insulin resistance levels (P=0.054) than AGA children. Ghrelin level was significantly lower in LGA born than AGA born children (P=0.001) even after controlling for age, sex, and BMI (P=0.006). There were no differences between genders in insulin and ghrelin levels. Multivariate analysis revealed that birth weight was the only significant parameter influencing ghrelin levels (R2=0.13, B=−0.007, P=0.002).ConclusionsLGA born non-obese prepubertal children have lower ghrelin levels when compared with age and BMI matched AGA children. Birth weight seems to have the only significant effect on the reduced ghrelin levels.

Abstract #91: Comparison of Cord Blood Insulin in Large-for-Gestational-Age Infants and Appropriate-for-Age Filipino Infants of Nondiabetic Mothers: A Pilot Study

2004 ◽  
Vol 10 ◽  
pp. 31
Author(s):  
Florence M. Amorado-Santos ◽  
Maria Honolina S. Gomez ◽  
Maria Victoria R. Olivares ◽  
Zayda N. Gamilla
Keyword(s):  
Pilot Study ◽  
Cord Blood ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
Blood Insulin
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