Robust Synthetic Gene Network Designs based on Library-search Method

2014 ◽  
Keyword(s):  
Gene Network ◽  
Search Method ◽  
Synthetic Gene ◽  
Library Search ◽  
Synthetic Gene Network

scholarly journals Robust synthetic gene network design via library-based search method

2011 ◽  
Vol 27 (19) ◽  
pp. 2700-2706 ◽  
Author(s):  
Chih-Hung Wu ◽  
Hsiao-Ching Lee ◽  
Bor-Sen Chen
Keyword(s):  
Network Design ◽  
Gene Network ◽  
Search Method ◽  
Synthetic Gene ◽  
Synthetic Gene Network

scholarly journals Phenotypic states become increasingly sensitive to perturbations near a bifurcation in a synthetic gene network

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Kevin Axelrod ◽  
Alvaro Sanchez ◽  
Jeff Gore
Keyword(s):  
Gene Network ◽  
Environmental Variability ◽  
Synthetic Gene ◽  
Phenotypic Switching ◽  
Proper Function ◽  
Critical Transition ◽  
Environmental Perturbations ◽  
The Face ◽  
Synthetic Gene Network ◽  
Open Question

Microorganisms often exhibit a history-dependent phenotypic response after exposure to a stimulus which can be imperative for proper function. However, cells frequently experience unexpected environmental perturbations that might induce phenotypic switching. How cells maintain phenotypic states in the face of environmental fluctuations remains an open question. Here, we use environmental perturbations to characterize the resilience of phenotypic states in a synthetic gene network near a critical transition. We find that far from the critical transition an environmental perturbation may induce little to no phenotypic switching, whereas close to the critical transition the same perturbation can cause many cells to switch phenotypic states. This loss of resilience was observed for perturbations that interact directly with the gene circuit as well as for a variety of generic perturbations-such as salt, ethanol, or temperature shocks-that alter the state of the cell more broadly. We obtain qualitatively similar findings in natural gene circuits, such as the yeast GAL network. Our findings illustrate how phenotypic memory can become destabilized by environmental variability near a critical transition.

Internal noise stochastic resonance of synthetic gene network

2005 ◽  
Vol 401 (1-3) ◽  
pp. 307-311 ◽  
Author(s):  
Zhiwei Wang ◽  
Zhonghuai Hou ◽  
Houwen Xin
Keyword(s):  
Stochastic Resonance ◽  
Gene Network ◽  
Internal Noise ◽  
Synthetic Gene ◽  
Synthetic Gene Network

Synthetic Gene Network for Entraining and Amplifying Cellular Oscillations

2002 ◽  
Vol 88 (14) ◽  
Author(s):  
Jeff Hasty ◽  
Milos Dolnik ◽  
Vivi Rottschäfer ◽  
James J. Collins
Keyword(s):  
Gene Network ◽  
Synthetic Gene ◽  
Synthetic Gene Network

Synthetic Gene Network with Positive Feedback Loop Amplifies Cellulase Gene Expression in Neurospora crassa

2018 ◽  
Vol 7 (5) ◽  
pp. 1395-1405 ◽  
Author(s):  
Toru Matsu-ura ◽  
Andrey A. Dovzhenok ◽  
Samuel T. Coradetti ◽  
Krithika R. Subramanian ◽  
Daniel R. Meyer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neurospora Crassa ◽  
Positive Feedback ◽  
Gene Network ◽  
Feedback Loop ◽  
Synthetic Gene ◽  
Cellulase Gene ◽  
Positive Feedback Loop ◽  
Synthetic Gene Network
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