Immunopathological Mechanisms and Oxidative Stress Damage in Multiple Sclerosis

2014 ◽  
pp. 549-588
Author(s):  
Sayonara Oliveira ◽  
Ana Kallaur ◽  
Damacio Kaimen-Maciel ◽  
Edna Vissoci Reiche
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Hervé Hervé Ngatanko Abaïssou ◽  
Eglantine Wado ◽  
Emmanuel Asongalem Acha ◽  
Ciobica Alin
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

2011 ◽  
Vol 71 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Lucian Hritcu ◽  
Alin Ciobica ◽  
Marius Stefan ◽  
Marius Mihasan ◽  
Lavinia Palamiuc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Memory Deficits ◽  
Rodent Model ◽  
Stress Damage ◽  
And Oxidative Stress

Benefit Agmatine Effects in Experimental Multiple Sclerosis. CNS Nitrosative and Oxidative Stress Suppression / Protektivni Efekti Agmatina U Eksperimentalnoj Multiploj Sklerozi. Supresija Nitrozativnog I Oksidativnog Stresa U CNS-U

2014 ◽  
Vol 31 (4) ◽  
pp. 233-243
Author(s):  
Ivana Stojanović ◽  
Srđan Ljubisavljević ◽  
Ivana Stevanović ◽  
Slavica Stojnev ◽  
Radmila Pavlović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Clinical Symptoms ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Autoimmune Encephalomyelitis ◽  
Sod Activity ◽  
Neuroprotective Effects ◽  
Sprague Dawley Rats ◽  
And Oxidative Stress

Summary The aim of this study was to investigate the exogenous agmatine influence on nitrosative and oxidative stress parameters in acute phase of multiple sclerosis (MS) experimental model, experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous injection of myelin basic protein (50 μg per animal). Sprague-Dawley rats were divided into five groups: I group - (CG), treated by PBS (i.p.), II group - (EAE), III group - (CFA), treated with Complete Freund’s adjuvant (0.2 ml subcutaneously), IV group - (EAE+AGM), treated by agmatine (75 mg/kg bw i.p.) upon EAE induction and V group - (AGM), received only agmatine in the same dose. The animals were treated every day during experiment - from day 0 to 15, and clinically scored every day. They were sacrificed on day 16 from MBP application. NO2+NO3, S-nitrosothiols (RSNO), malondyaldehide (MDA) and reduced glutathione (GSH) concentrations and superoxide dismutase (SOD) activity were determined in rat whole encephalitic mass (WEM) and cerebellum homogenates. Agmatine exerted strong protective effects on EAE clinical symptoms (p<0.05). In EAE brain homogenates, NO2+NO3, RSNO and MDA concentrations were increased compared to CG values. Agmatine treatment diminished NO2+NO3, RSNO and MDA levels in EAE animals (p<0.05). In EAE rats, GSH level and SOD activity were decreased compared to CG values, but agmatine treatment increased both parameters compared to EAE untreated animals (p<0.05). Immunohistochemical staining supported the clinical and biochemical findings in all groups. The CNS changes in EAE are successfully supressed by agmatine application, which could be the the new aspect of the neuroprotective effects of agmatine.

scholarly journals Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Genaro G. Ortiz ◽  
Fermín P. Pacheco-Moisés ◽  
Oscar K. Bitzer-Quintero ◽  
Ana C. Ramírez-Anguiano ◽  
Luis J. Flores-Alvarado ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Tissue Injury ◽  
Autoimmune Disorder ◽  
Demyelinating Lesions ◽  
The Central Nervous System ◽  
The Brain ◽  
And Oxidative Stress

Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune disorder including breakdown of the blood-brain barrier (BBB), the recruitment of lymphocytes, microglia, and macrophages to lesion sites, the presence of multiple lesions, generally being more pronounced in the brain stem and spinal cord, the predominantly perivascular location of lesions, the temporal maturation of lesions from inflammation through demyelination, to gliosis and partial remyelination, and the presence of immunoglobulin in the central nervous system and cerebrospinal fluid. Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. Pro-inflammatory cytokines amplify the inflammatory cascade by compromising the BBB, recruiting immune cells from the periphery, and activating resident microglia. inflammation-associated oxidative burst in activated microglia and macrophages plays an important role in the demyelination and free radical-mediated tissue injury in the pathogenesis of MS. The inflammatory environment in demyelinating lesions leads to the generation of oxygen- and nitrogen-free radicals as well as proinflammatory cytokines which contribute to the development and progression of the disease. Inflammation can lead to oxidative stress and vice versa. Thus, oxidative stress and inflammation are involved in a self-perpetuating cycle.

Multiple sclerosis and oxidative stress—a clinical perspective

2013 ◽  
Vol 7 (1) ◽  
pp. 76-86 ◽  
Author(s):  
M. S. Kostic ◽  
J. S. Rajkovic ◽  
M. S. Potic Floranovic ◽  
I. D. Dimov ◽  
D. D. Pavlovic
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Clinical Perspective ◽  
And Oxidative Stress

Genistein abrogates pre-hemolytic and oxidative stress damage induced by 2,2′-Azobis (Amidinopropane)

Life Sciences ◽  
2006 ◽  
Vol 78 (11) ◽  
pp. 1202-1210 ◽  
Author(s):  
Andréa Name Colado Simão ◽  
Andréia Akemi Suzukawa ◽  
Maria Fernanda Casado ◽  
Rossinei Danieli Oliveira ◽  
Flávia Alessandra Guarnier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Relationship between inflammation and oxidative stress and its effect on multiple sclerosis

Neurología ◽  
2021 ◽  
Author(s):  
E.J. Ramos-González ◽  
O.K. Bitzer-Quintero ◽  
G. Ortiz ◽  
J.J. Hernández-Cruz ◽  
L.J. Ramírez-Jirano
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
And Oxidative Stress

Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis

2021 ◽  
Vol 20 ◽  
Author(s):  
Begoña M. Escribano ◽  
Ana Muñoz-Jurado ◽  
Evelio Luque ◽  
Cristina Conde ◽  
Montse Feijóo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Oxidative Damage ◽  
Clinical Status ◽  
Lipid Peroxides ◽  
Redox System ◽  
Dark Agouti ◽  
Glutathione Redox System ◽  
And Oxidative Stress ◽  
Glutathione Redox

Background and Objectives: Experimental autoimmune encephalomyelitis (EAE) in rats closely reproduces multiple sclerosis (MS), a disease characterized by neuroinflammation and oxidative stress, that also appears to extend to other organ compartments. The origin of MS is a matter for discussion, but it would seem that altering certain bacterial populations present in the gut may lead to a proinflammatory condition due to the bacterial lipopolysaccharides (LPS) in the so-called brain-gut axis. The casein and lactose in milk confer anti-inflammatory properties and immunomodulatory effects. The objectives of this study were: to evaluate the effects of administration of casein and lactose on the oxidative damage and the clinical status caused by EAE, and to verify whether both, casein and lactose, had any effect on the LPS and its transport protein -LBP-. Methods: Twenty male dark Agouti rats were divided into: control rats (control), EAE rats and EAE rats to which casein and lactose, EAE+casein and EAE+lactose, respectively, were administered. Fifty-one days after casein and lactose administration, the rats were sacrificed and different organs were studied (brain, spinal cord, blood, heart, liver, kidney, small and large intestine). In the latter, products derived from oxidative stress were studied (lipid peroxides and carbonylated proteins) as well as the glutathione redox system, various inflammation factors (total nitrite, Nuclear Factor-kappa B p065, the Rat Tumour Necrosis Factor-α) and the LPS and LBP values. Results and Conclusion: Casein and lactose administration improved the clinical aspect of the disease at the same time as reducing inflammation and oxidative stress, exerting its action on the glutathione redox system or increasing GPx levels.

Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress

2018 ◽  
Vol 14 (1) ◽  
pp. 15-23
Author(s):  
Ada Paloma Soto-Brambila ◽  
Genaro Gabriel Ortiz ◽  
Paloma Rivero-Moragrega ◽  
Ana Laura Briones-Torres ◽  
Luis Javier Gonzalez-Ortiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Immune System ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
And Oxidative Stress

scholarly journals Mangifera indicaFruit Extract Improves Memory Impairment, Cholinergic Dysfunction, and Oxidative Stress Damage in Animal Model of Mild Cognitive Impairment

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Wipawee Thukham-Mee ◽  
Kornkanok Ingkaninan ◽  
Sakchai Wittaya-Areekul
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Impairment ◽  
Cholinergic Neurons ◽  
Protective Agent ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

To date, the effective preventive paradigm against mild cognitive impairment (MCI) is required. Therefore, we aimed to determine whetherMangifera indicafruit extract, a substance possessing antioxidant and cognitive enhancing effects, could improve memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. Male Wistar rats, weighing 180–200 g, were orally given the extract at doses of 12.5, 50, and 200 mg·kg−1BW for 2 weeks before and 1 week after the bilateral injection of AF64A (icv). At the end of study, spatial memory, cholinergic neurons density, MDA level, and the activities of SOD, CAT, and GSH-Px enzymes in hippocampus were determined. The results showed that all doses of extract could improve memory together with the decreased MDA level and the increased SOD and GSH-Px enzymes activities. The increased cholinergic neurons density in CA1 and CA3 of hippocampus was also observed in rats treated with the extract at doses of 50 and 200 mg·kg−1BW. Therefore, our results suggested thatM. indica, the potential protective agent against MCI, increased cholinergic function and the decreased oxidative stress which in turn enhanced memory. However, further researches are essential to elucidate the possible active ingredients and detail mechanism.

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