Coal Tar, Anthralin, Salicylic Acid, and Lactic Acid

2014 ◽  
pp. 85-95
Author(s):  
Sarah Fitzmaurice ◽  
John Y. M. Koo
Keyword(s):  
Salicylic Acid ◽  
Lactic Acid ◽  
Coal Tar

H+-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo

2002 ◽  
Vol 282 (5) ◽  
pp. C1064-C1075 ◽  
Author(s):  
Akiko Emoto ◽  
Fumihiko Ushigome ◽  
Noriko Koyabu ◽  
Hiroshi Kajiya ◽  
Koji Okabe ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Lactic Acid ◽  
Cell Line ◽  
Intracellular Ph ◽  
Trophoblast Cell ◽  
Monocarboxylate Transporter ◽  
Human Trophoblast ◽  
Inflammatory Drugs ◽  
Ph Dependent ◽  
Trophoblast Cell Line

We investigated the transport of salicylic acid and l-lactic acid across the placenta using the human trophoblast cell line BeWo. We performed uptake experiments and measured the change in intracellular pH (pHi). The uptakes of [14C]salicylic acid andl-[14C]lactic acid were temperature- and extracellular pH-dependent and saturable at higher concentrations. Both uptakes were also reduced by FCCP, nigericin, and NaN3. Various nonsteroidal anti-inflammatory drugs (NSAIDs) strongly inhibited the uptake of l-[14C]lactic acid. Salicylic acid and ibuprofen noncompetitively inhibited the uptake ofl-[14C]lactic acid. α-Cyano-4-hydroxycinnamate (CHC), a monocarboxylate transporter inhibitor, suppressed the uptake ofl-[14C]lactic acid but not that of [14C]salicylic acid. CHC also suppressed the decrease of pHi induced by l-lactic acid but had little effect on that induced by salicylic acid or diclofenac. These results suggest that NSAIDs are potent inhibitors of lactate transporters, although they are transported mainly by a transport system distinct from that for l-lactic acid.

Effects of salicylates on exercise metabolism

1962 ◽  
Vol 17 (4) ◽  
pp. 665-668 ◽  
Author(s):  
John A. Downey ◽  
Robert C. Darling
Keyword(s):  
Salicylic Acid ◽  
Oxygen Consumption ◽  
Lactic Acid ◽  
Cardiovascular System ◽  
Pulmonary Ventilation ◽  
Metabolic Effects ◽  
Moderate Exercise ◽  
Young Males ◽  
Analysis Of Results ◽  
Temperature Controlled

Some metabolic effects of salicylates were measured on ten normal young males steadily performing controlled moderate exercise after administration of acetyl salicylic acid (ASA). Dosages at a rate up to 4.8 g/day were administered over lengthening periods, the last dose 1frac12–2 hr before walking on a power-driven treadmill in a temperature-controlled room. Oxygen consumption was measured, as were pulmonary ventilation, pulse rate, and blood lactic acid. While analysis of results indicated increase in resting O2 consumption within 2 hr of the first dose, no modification of O2 consumption of exercise appeared. Pulmonary ventilation was not increased after one dose, but did increase at rest, during exercise, and recovery after longer dosage; O2 extraction from each unit of ventilation increased after one dose at rest and during exercise; the extraction ratio was still increased at rest after longer administration of ASA, but decreased during exercise and recovery. Increased ventilation was predominantly effected by increased depth of respiration rather than by changes in rate. Pulse rates were not changed and no significant effects on the cardiovascular system were discerned in this respect. Submitted on March 10, 1962

Paints for warts: salicylic acid collodion BNF

1978 ◽  
Vol 16 (17) ◽  
pp. 68.1-68
Keyword(s):  
Clinical Trials ◽  
Salicylic Acid ◽  
Lactic Acid ◽  
Controlled Trials ◽  
Collodion Film

A reader has pointed out that our article on paints for warts (December 9, 1977, p. 97) should have included the BNF preparation, Salicylic Acid Collodion (salicylic acid 12% in flexible collodion). It differs from Salactol and Duofilm in that it contains no lactic acid, and 12% instead of about 17% salicylic acid. Clinical trials with it have not been published, but its ingredients suggest that it should be effective. It seems likely that a higher concentration of salicylic acid than 12% would increase the efficacy of the paint. The contribution of lactic acid is uncertain; if it prevents complete drying of the collodion film it might facilitate the release of salicylic acid to the skin. Controlled trials are needed, and reformulation of the paint should be considered when the BNF is revised.

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