Role of Endogenous Neural Precursor Cells in Multiple

2014 ◽  
pp. 100-124
Keyword(s):  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

Role of drug transporters and heat shock proteins during ethanol exposure to human neural precursor cells and its lineages

2018 ◽  
Vol 51 ◽  
pp. 14-23 ◽  
Author(s):  
Sandeep Kumar Vishwakarma ◽  
Nusrath Fatima ◽  
Chandrakala Lakkireddy ◽  
Nagarapu Raju ◽  
Avinash Bardia ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Drug Transporters ◽  
Ethanol Exposure ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Shock Proteins

Role of endogenous neural precursor cells in demyelination and remyelination after cuprizone-induced injury

2014 ◽  
Vol 275 (1-2) ◽  
pp. 188-189
Author(s):  
Erica Butti ◽  
Giulia Berera ◽  
Francesca Ruffini ◽  
Linda Chaabane ◽  
Giorgia Dina ◽  
...  
Keyword(s):  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

scholarly journals Role of neural precursor cells in promoting repair following stroke

2012 ◽  
Vol 34 (1) ◽  
pp. 78-90 ◽  
Author(s):  
Pooya Dibajnia ◽  
Cindi M Morshead
Keyword(s):  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

scholarly journals Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growth

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1120
Author(s):  
Letizia Messa ◽  
Bianca Barzaghini ◽  
Federica Rey ◽  
Cecilia Pandini ◽  
Gian Vincenzo Zuccotti ◽  
...  
Keyword(s):  
Cell Biology ◽  
Cellular Response ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Functional Enrichment ◽  
Neural Precursor ◽  
Mechanical Stimuli ◽  
3D Scaffold ◽  
Non Coding Rnas

Non-coding RNAs show relevant implications in various biological and pathological processes. Thus, understanding the biological implications of these molecules in stem cell biology still represents a major challenge. The aim of this work is to study the transcriptional dysregulation of 357 non-coding genes, found through RNA-Seq approach, in murine neural precursor cells expanded inside the 3D micro-scaffold Nichoid versus standard culture conditions. Through weighted co-expression network analysis and functional enrichment, we highlight the role of non-coding RNAs in altering the expression of coding genes involved in mechanotransduction, stemness, and neural differentiation. Moreover, as non-coding RNAs are poorly conserved between species, we focus on those with human homologue sequences, performing further computational characterization. Lastly, we looked for isoform switching as possible mechanism in altering coding and non-coding gene expression. Our results provide a comprehensive dissection of the 3D scaffold Nichoid’s influence on the biological and genetic response of neural precursor cells. These findings shed light on the possible role of non-coding RNAs in 3D cell growth, indicating that also non-coding RNAs are implicated in cellular response to mechanical stimuli.

scholarly journals PRDX6 inhibits neurogenesis of neural precursor cells through downregulation of wdfy1 mediated TLR4 signal

2016 ◽  
Author(s):  
Mi Hee Park ◽  
Dong Ju Son ◽  
Kyoung Tak Nam ◽  
So Young Kim ◽  
Sang Yeon Oh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Pc12 Cells ◽  
Molecular Mechanisms ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Peroxiredoxin 6 ◽  
Pc 12 Cells

AbstractImpaired neurogenesis has been associated with brain disorders. The role of peroxiredoxin 6 (PRDX6) in the neurodegenerative diseases is very controversial. To demonstrate the role of PRDX6 in neurogenesis, we compared neurogenesis ability and studied the molecular mechanisms. It was found that the neurogenesis of neural stem cells and expression of the marker protein were lowered in PRDX6 Tg-mice compared with non-tg mice. Moreover, the expression of wdfy1 was dramatically decreased in PRDX6-Tg mice, also, we observed that wdfy1 siRNA decreases the differentiation ability of primary neural stem cells to astrocyte and neuronal cells as well as PC12 cells. However, knockdown of PRDX6 recovered neurogenesis in the brain of PRDX6-Tg mice as well as PC-12 cells. We also showed that TLR4 was dramatically reduced in PRDX6 Tg mice as well as PC-12 cells and PRDX6 overexpression reduced neurogenesis was rescued after treatment of TLR4 siRNA. We further found that reduced TLR4 expression and neurogenesis was reversed in the neuron from PRDX6-Tg mice as well as PC12 cells by introduction of wdfy1 plasmid. Moreover, TLR4 siRNA reduced neurogenesis and wdfy1 expression. This study indicated that PRDX6 inhibits neurogenesis of neural precursor cells through TLR4 dependent downregulation of wdfy1.

Abstract WP149: Post-stroke Vascular Remodeling and the Role of Neural Precursor Cells

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Michael R Williamson ◽  
Andrew K Dunn ◽  
Michael R Drew ◽  
Theresa A Jones
Keyword(s):  
Vascular Remodeling ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Post Stroke

scholarly journals The role of neural precursor cells and self assembling peptides in nerve regeneration

2013 ◽  
Vol 42 (1) ◽  
pp. 60 ◽  
Author(s):  
Xiao Zhao ◽  
Gordon S Liu ◽  
Yang Liu ◽  
Jian Wang ◽  
Kajana Satkunendrarajah ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Self Assembling
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