scholarly journals Interleukin-6 and Cyclooxygenase-2 Downregulation by Fatty-Acid Fractions of Ranunculus Constantinopolitanus

2014 ◽  
pp. 39-61
Author(s):  
Sabreen Fostok ◽  
Rima Ezzeddine ◽  
Fadia Homaidan ◽  
Jamal Al-Saghir ◽  
Ralph Salloum ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Interleukin 6 ◽  
Cyclooxygenase 2

scholarly journals Interleukin-6 and Cyclooxygenase-2 downregulation by fatty-acid fractions of Ranunculus constantinopolitanus

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Sabreen F Fostok ◽  
Rima A Ezzeddine ◽  
Fadia R Homaidan ◽  
Jamal A Al-Saghir ◽  
Ralph G Salloum ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Interleukin 6 ◽  
Cyclooxygenase 2

scholarly journals Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Diabetes ◽  
2006 ◽  
Vol 55 (10) ◽  
pp. 2688-2697 ◽  
Author(s):  
A. L. Carey ◽  
G. R. Steinberg ◽  
S. L. Macaulay ◽  
W. G. Thomas ◽  
A. G. Holmes ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Kinase ◽  
Glucose Uptake ◽  
Fatty Acid Oxidation ◽  
Interleukin 6 ◽  
Glucose Disposal ◽  
Acid Oxidation ◽  
Amp Activated Protein Kinase

Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility

2021 ◽  
Author(s):  
Sasha Z. Prisco ◽  
Lynn M. Hartweck ◽  
Lauren Rose ◽  
Patricia D.A. Lima ◽  
Thenappan Thenappan ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Fatty Acid ◽  
Pulmonary Artery ◽  
Right Ventricular ◽  
Interleukin 6 ◽  
Acid Oxidation ◽  
Mitochondrial Morphology ◽  
Interacting Proteins ◽  
Transmission Electron

Background: Right ventricular dysfunction (RVD) is the leading cause of death in pulmonary arterial hypertension (PAH), but no RV-specific therapy exists. We showed microtubule-mediated junctophilin-2 dysregulation (MT-JPH2 pathway) causes t-tubule disruption and RVD in rodent PAH, but the druggable regulators of this critical pathway are unknown. GP130 (glycoprotein 130) activation induces cardiomyocyte microtubule remodeling in vitro; however, the effects of GP130 signaling on the MT-JPH2 pathway and RVD resulting from PAH are undefined. Methods: Immunoblots quantified protein abundance, quantitative proteomics defined RV microtubule-interacting proteins (MT-interactome), metabolomics evaluated the RV metabolic signature, and transmission electron microscopy assessed RV cardiomyocyte mitochondrial morphology in control, monocrotaline, and monocrotaline-SC-144 (GP130 antagonist) rats. Echocardiography and pressure-volume loops defined the effects of SC-144 on RV-pulmonary artery coupling in monocrotaline rats (8–16 rats per group). In 73 patients with PAH, the relationship between interleukin-6, a GP130 ligand, and RVD was evaluated. Results: SC-144 decreased GP130 activation, which normalized MT-JPH2 protein expression and t-tubule structure in the monocrotaline RV. Proteomics analysis revealed SC-144 restored RV MT-interactome regulation. Ingenuity pathway analysis of dysregulated MT-interacting proteins identified a link between microtubules and mitochondrial function. Specifically, SC-144 prevented dysregulation of electron transport chain, Krebs cycle, and the fatty acid oxidation pathway proteins. Metabolomics profiling suggested SC-144 reduced glycolytic dependence, glutaminolysis induction, and enhanced fatty acid metabolism. Transmission electron microscopy and immunoblots indicated increased mitochondrial fission in the monocrotaline RV, which SC-144 mitigated. GP130 antagonism reduced RV hypertrophy and fibrosis and augmented RV-pulmonary artery coupling without altering PAH severity. In patients with PAH, higher interleukin-6 levels were associated with more severe RVD (RV fractional area change 23±12% versus 30±10%, P =0.002). Conclusions: GP130 antagonism reduces MT-JPH2 dysregulation, corrects metabolic derangements in the RV, and improves RVD in monocrotaline rats.

scholarly journals Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice

2008 ◽  
Vol 28 (9) ◽  
pp. 1877-1886 ◽  
Author(s):  
Rozenn Mingam ◽  
Aurélie Moranis ◽  
Rose-Marie Bluthé ◽  
Véronique De Smedt-Peyrusse ◽  
Keith W. Kelley ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Interleukin 6 ◽  
Signalling Pathway ◽  
Sickness Behaviour

Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues

2019 ◽  
Vol 127 (4) ◽  
pp. 309-317 ◽  
Author(s):  
Celeste Sánchez-Romero ◽  
Adalberto Mosqueda-Taylor ◽  
Wilson Delgado-Azañero ◽  
Oslei Paes de Almedia ◽  
Ronell Bologna-Molina
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Cyclooxygenase 2
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