Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine

2014 ◽  
pp. 41-56 ◽  
Keyword(s):  
Engineered Nanoparticles

REVIEW ON RECENT ADVANCES IN ENVIRONMENTAL REMEDIATION AND RELATED TOXICITY OF ENGINEERED NANOPARTICLES

2016 ◽  
Vol 15 (4) ◽  
pp. 923-934 ◽  
Author(s):  
Mohammadreza Kamali ◽  
Ana Paula Duarte Gomes ◽  
Zahra Khodaparast ◽  
Tahereh Seifi
Keyword(s):  
Environmental Remediation ◽  
Engineered Nanoparticles ◽  
Recent Advances

Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Triple Negative ◽  
Growth Factor Receptor ◽  
Engineered Nanoparticles ◽  
Efficacy Evaluation ◽  
Dual Action ◽  
Epidermal Growth ◽  
Laminin 411 ◽  
Immunologic Analysis

Engineered nanoparticles are widely used for delivery of drugs but frequently lack proof of safetyfor cancer patient's treatment. All-in-one covalent nanodrugs of the third generation have beensynthesized based on a poly(β-L-malic acid) (PMLA) platform, targeting human triple-negativebreast cancer (TNBC). They significantly inhibited tumor growth in nude mice by blockingsynthesis of epidermal growth factor receptor, and α4 and β1 chains of laminin-411, the tumorvascular wall protein and angiogenesis marker. PMLA and nanodrug biocompatibility and toxicityat low and high dosages were evaluated in vitro and in vivo. The dual-action nanodrug and singleactionprecursor nanoconjugates were assessed under in vitro conditions and in vivo with multipletreatment regimens (6 and 12 treatments). The monitoring of TNBC treatment in vivo withdifferent drugs included blood hematologic and immunologic analysis after multiple intravenousadministrations. The present study demonstrates that the dual-action nanoconju-gate is highlyeffective in preclinical TNBC treatment without side effects, supported by hematologic andimmunologic assays data. PMLA-based nanodrugs of the Polycefin™ family passed multipletoxicity and efficacy tests in vitro and in vivo on preclinical level and may prove to be optimizedand efficacious for the treatment of cancer patients in the future.

Engineered Nanoparticles with Antimicrobial Property

2018 ◽  
Vol 18 (11) ◽  
pp. 1040-1054 ◽  
Author(s):  
Veliyath Gopi Reshma ◽  
Santhakumar Syama ◽  
Sudhakaran Sruthi ◽  
Sebastain Cherian Reshma ◽  
Nirmal Suma Remya ◽  
...  
Keyword(s):  
Antimicrobial Property ◽  
Engineered Nanoparticles

Coating ligands mediated dynamic formation of natural organic matter (NOM) corona on engineered nanoparticles in environments

2021 ◽  
Author(s):  
Chuan-Wang Yang ◽  
Li Yuan ◽  
Hong-Zhi Zhou ◽  
Xin Zhang ◽  
Guo-Ping Sheng
Keyword(s):  
Organic Matter ◽  
Natural Organic Matter ◽  
Engineered Nanoparticles ◽  
Aquatic Systems ◽  
Solution Interface ◽  
Dynamic Formation

Natural organic matter (NOM) can adsorb onto engineered nanoparticles (ENPs) and form NOM-corona on ENPs-solution interface, thus affecting the performance and ecotoxicity of ENPs in aquatic systems. Nevertheless, the formation...

Current trends and challenges in analysis and characterization of engineered nanoparticles in seawater

Talanta ◽  
2021 ◽  
Vol 226 ◽  
pp. 122201
Author(s):  
Andrei R. Timerbaev ◽  
Olga V. Kuznetsova ◽  
Bernhard K. Keppler
Keyword(s):  
Engineered Nanoparticles ◽  
Current Trends

scholarly journals Engineered Nanoparticles with Decoupled Photocatalysis and Wettability for Membrane-Based Desalination and Separation of Oil-Saline Water Mixtures

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1397
Author(s):  
Bishwash Shrestha ◽  
Mohammadamin Ezazi ◽  
Gibum Kwon
Keyword(s):  
Membrane Fouling ◽  
Municipal Wastewater ◽  
Uv Light ◽  
Saline Water ◽  
Membrane Surface ◽  
Sio2 Nanoparticles ◽  
Engineered Nanoparticles ◽  
Water Mixture ◽  
Organic Substances ◽  
Suspended Substances

Membrane-based separation technologies are the cornerstone of remediating unconventional water sources, including brackish and industrial or municipal wastewater, as they are relatively energy-efficient and versatile. However, membrane fouling by dissolved and suspended substances in the feed stream remains a primary challenge that currently prevents these membranes from being used in real practices. Thus, we directly address this challenge by applying a superhydrophilic and oleophobic coating to a commercial membrane surface which can be utilized to separate and desalinate an oil and saline water mixture, in addition to photocatalytically degrading the organic substances. We fabricated the photocatalytic membrane by coating a commercial membrane with an ultraviolet (UV) light-curable adhesive. Then, we sprayed it with a mixture of photocatalytic nitrogen-doped titania (N-TiO2) and perfluoro silane-grafted silica (F-SiO2) nanoparticles. The membrane was placed under a UV light, which resulted in a chemically heterogeneous surface with intercalating high and low surface energy regions (i.e., N-TiO2 and F-SiO2, respectively) that were securely bound to the commercial membrane surface. We demonstrated that the coated membrane could be utilized for continuous separation and desalination of an oil–saline water mixture and for simultaneous photocatalytic degradation of the organic substances adsorbed on the membrane surface upon visible light irradiation.

scholarly journals Describing Phosphorus Sorption Processes on Volcanic Soil in the Presence of Copper or Silver Engineered Nanoparticles

Minerals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 373
Author(s):  
Jonathan Suazo-Hernández ◽  
Erwin Klumpp ◽  
Nicolás Arancibia-Miranda ◽  
Patricia Poblete-Grant ◽  
Alejandra Jara ◽  
...  
Keyword(s):  
Organic Matter ◽  
Crop Production ◽  
Agricultural Soils ◽  
Ph Value ◽  
Consumer Products ◽  
Soil Samples ◽  
Engineered Nanoparticles ◽  
P Availability ◽  
Agricultural Crop ◽  
Phosphorus Sorption

Engineered nanoparticles (ENPs) present in consumer products are being released into the agricultural systems. There is little information about the direct effect of ENPs on phosphorus (P) availability, which is an essential nutrient for crop growthnaturally occurring in agricultural soils. The present study examined the effect of 1, 3, and 5% doses of Cu0 or Ag0 ENPs stabilized with L-ascorbic acid (suspension pH 2–3) on P ad- and desorption in an agricultural Andisol with total organic matter (T-OM) and with partial removal of organic matter (R-OM) by performing batch experiments. Our results showed that the adsorption kinetics data of H2PO4− on T-OM and R-OM soil samples with and without ENPs were adequately described by the pseudo-second-order (PSO) and Elovich models. The adsorption isotherm data of H2PO4− from T-OM and R-OM soil samples following ENPs addition were better fitted by the Langmuir model than the Freundlich model. When the Cu0 or Ag0 ENPs doses were increased, the pH value decreased and H2PO4− adsorption increased on T-OM and R-OM. The H2PO4− desorption (%) was lower with Cu0 ENPs than Ag0 ENPs. Overall, the incorporation of ENPs into Andisols generated an increase in P retention, which may affect agricultural crop production.

scholarly journals Delivery of cancer therapies by synthetic and bio-inspired nanovectors

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Tina Briolay ◽  
Tacien Petithomme ◽  
Morgane Fouet ◽  
Nelly Nguyen-Pham ◽  
Christophe Blanquart ◽  
...  
Keyword(s):  
Recent Literature ◽  
Biological Properties ◽  
Engineered Nanoparticles ◽  
Oncolytic Viruses ◽  
Cancer Therapies ◽  
Different Types ◽  
Therapeutic Molecules ◽  
Tumor Specificity ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background As a complement to the clinical development of new anticancer molecules, innovations in therapeutic vectorization aim at solving issues related to tumor specificity and associated toxicities. Nanomedicine is a rapidly evolving field that offers various solutions to increase clinical efficacy and safety. Main Here are presented the recent advances for different types of nanovectors of chemical and biological nature, to identify the best suited for translational research projects. These nanovectors include different types of chemically engineered nanoparticles that now come in many different flavors of ‘smart’ drug delivery systems. Alternatives with enhanced biocompatibility and a better adaptability to new types of therapeutic molecules are the cell-derived extracellular vesicles and micro-organism-derived oncolytic viruses, virus-like particles and bacterial minicells. In the first part of the review, we describe their main physical, chemical and biological properties and their potential for personalized modifications. The second part focuses on presenting the recent literature on the use of the different families of nanovectors to deliver anticancer molecules for chemotherapy, radiotherapy, nucleic acid-based therapy, modulation of the tumor microenvironment and immunotherapy. Conclusion This review will help the readers to better appreciate the complexity of available nanovectors and to identify the most fitting “type” for efficient and specific delivery of diverse anticancer therapies.

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