scholarly journals Cluster Analysis Of Obesity And Asthma Phenotypes

2016 ◽  
pp. 269-286
Keyword(s):  
Cluster Analysis ◽  
Asthma Phenotypes

Sex-Specific Asthma Phenotypes, Inflammatory Patterns, and Asthma Control in a Cluster Analysis

2019 ◽  
Vol 7 (2) ◽  
pp. 556-567.e15 ◽  
Author(s):  
Han-Pin Hsiao ◽  
Meng-Chih Lin ◽  
Chao-Chien Wu ◽  
Chin-Chou Wang ◽  
Tsu-Nai Wang
Keyword(s):  
Cluster Analysis ◽  
Asthma Control ◽  
Asthma Phenotypes

Identification of asthma phenotypes based on extrapulmonary treatable traits

2020 ◽  
pp. 2000240 ◽  
Author(s):  
Patricia Duarte Freitas ◽  
Rafaella França Xavier ◽  
Vanessa Marie McDonald ◽  
Peter Gerard Gibson ◽  
Laura Cordova-Rivera ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cluster Analysis ◽  
Health Status ◽  
Asthma Control ◽  
Severe Asthma ◽  
Sedentary Time ◽  
Depression Symptoms ◽  
Uncontrolled Asthma ◽  
Asthma Phenotypes ◽  
Physically Inactive

BackgroundAsthma is a heterogeneous and complex disease, and the description of asthma phenotypes based on extrapulmonary treatable traits has not been previously reported.Objectiveto identify and characterise clusters based on clinical, functional, anthropometrical, and psychological characteristics in participants with moderate-to-severe asthma.MethodsThis is a cross-sectional multicentre study involving centres from Brazil and Australia. Participants (N=296) with moderate-to-severe asthma were consecutively recruited. Physical activity and sedentary time, clinical asthma control, anthropometric data, pulmonary function, psychological, and health-status were evaluated. Participants were classified by hierarchical cluster analysis and the clusters compared using ANOVA, Kruskal-Wallis, and Chi-square tests. Multiple logistic and linear regression models were performed to evaluate the association between variables.ResultsWe identified four clusters: (1)controlled asthma who were physically active, (2)uncontrolled asthma who were physically inactive and more sedentary, (3)uncontrolled asthma with low physical activity, who were also obese and experienced anxiety and/or depression symptoms (4)very uncontrolled asthma, who were physically inactive, more sedentary, obese and experienced anxiety and/or depression symptoms. Higher levels of sedentary time, female sex, and anxiety symptoms were associated with increased odds of exacerbation risk while being more active showed a protective factor for hospitalisation. Asthma control was associated with sex, the occurrence of exacerbation, physical activity, and health-status.ConclusionTraits such as physical inactivity, obesity, and symptoms of anxiety and/or depression were associated with worse asthma outcomes, and closely and inextricably with asthma control. This cluster analysis supports the importance of assessing extrapulmonary traits to improve personalised management and outcomes for people with moderate and severe asthma.

scholarly journals Cluster Analysis and Clinical Asthma Phenotypes

2008 ◽  
Vol 178 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Pranab Haldar ◽  
Ian D. Pavord ◽  
Dominic E. Shaw ◽  
Michael A. Berry ◽  
Michael Thomas ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Asthma Phenotypes ◽  
Clinical Asthma

Identification of asthma phenotypes using cluster analysis

2018 ◽  
Author(s):  
Patricia D Freitas ◽  
Rafaella F Xavier ◽  
Simone T C da Silva ◽  
Regina M Carvalho-Pinto ◽  
Rafael Stelmach ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Asthma Phenotypes

scholarly journals Cluster Analysis of Obesity and Asthma Phenotypes

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36631 ◽  
Author(s):  
E. Rand Sutherland ◽  
Elena Goleva ◽  
Tonya S. King ◽  
Erik Lehman ◽  
Allen D. Stevens ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Asthma Phenotypes

scholarly journals Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

2014 ◽  
Vol 133 (6) ◽  
pp. 1557-1563.e5 ◽  
Author(s):  
Wendy C. Moore ◽  
Annette T. Hastie ◽  
Xingnan Li ◽  
Huashi Li ◽  
William W. Busse ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Severe Asthma ◽  
Asthma Phenotypes

scholarly journals Acute Exacerbation of Asthma Phenotypes and Prognosis Identified by Cluster Analysis

2019 ◽  
Vol 143 (2) ◽  
pp. AB3
Author(s):  
Xin Zhang ◽  
Li Zhang ◽  
Ying Liu ◽  
Gang Wang ◽  
Rui Liang ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Acute Exacerbation ◽  
Asthma Phenotypes
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