Mechanisms of Catecholamine and Polypeptide Hormone Action: I (Receptors and Second Messengers)

2012 ◽  
pp. 20-21
Keyword(s):  
Second Messengers ◽  
Hormone Action ◽  
Polypeptide Hormone

The function of glycosyl phosphoinositides in hormone action

1988 ◽  
Vol 320 (1199) ◽  
pp. 345-358 ◽  
Keyword(s):  
Membrane Fraction ◽  
Inositol Phosphate ◽  
Second Messengers ◽  
Chemical Substance ◽  
Hormone Action ◽  
Glycosyl Phosphatidylinositol ◽  
Molecular Events ◽  
Fat Liver ◽  
Hydrolysis Of

The molecular events involved in the cellular actions of insulin remain unexplained. Some of the acute actions of the hormone may be due to the intracellular generation of a chemical substance which modulates certain enzyme activities. Such an enzymemodulating substance has been identified as an inositol phosphate-glycan, produced by the insulin-sensitive hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-Ptdlns) precursor. This precursor glycolipid is structurally similar to the glycosylphosphoinositide membrane protein anchor. The exposure of fat, liver or muscle cells to insulin results in the hydrolysis of glycosyl-Ptdlns, giving rise to the inositol phosphate glycan and diacylglycerol. This hydrolysis reaction is catalysed by a glycosyl-PtdIns-specific phospholipase C. This enzyme has been characterized and purified from a plasma membrane fraction of liver. This reaction also results in the acute release of certain glycosyl-Ptdlns-anchored proteins from the cell surface. Elucidation of the functional role of glycosyl-phosphoinositides in the generation of second messengers or the release of proteins may provide further insights into the pleiotropic nature of insulin action.

A Two-Way Street: Hormone Action and Brain Function

PsycCRITIQUES ◽  
2009 ◽  
Vol 54 (49) ◽  
Author(s):  
Josephine F. Wilson
Keyword(s):  
Brain Function ◽  
Hormone Action

Molecular mechanisms of sex-dependent thyroid hormone action on target tissues

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
H Rakov ◽  
K Engels ◽  
D Zwanziger ◽  
M Renders ◽  
K Brix ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Molecular Mechanisms ◽  
Hormone Action ◽  
Thyroid Hormone Action

THE RELATION BETWEEN AMINE AND POLYPEPTIDE HORMONE IN CALCITONIN-PRODUCING CELLS

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S213
Author(s):  
Frank Sundler ◽  
A. Melander ◽  
Ch. Owman
Keyword(s):  
Polypeptide Hormone

A new tool for investigating the function of the two second messengers of the phosphoinositide system: RHC 80267

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S44-S45
Author(s):  
A. PFEIFFER ◽  
B. NOELKE ◽  
H. ROCHLITZ
Keyword(s):  
Second Messengers
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