Pathophysiology of Gastric Ulcer Disease

2014 ◽  
pp. 95-98
Author(s):  
Michael Murray
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Disease

scholarly journals Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions

Dose-Response ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 155932582110012
Author(s):  
Shaimaa M. Badr-Eldin ◽  
Usama A. Fahmy ◽  
Hibah M. Aldawsari ◽  
Osama A. A. Ahmed ◽  
Nabil A. Alhakamy ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Delivery System ◽  
Lipoic Acid ◽  
Tween 80 ◽  
Protective Effects ◽  
Alpha Lipoic Acid ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Mucosal Defect ◽  
Polyethylene Glycol 200

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. Alpha-lipoic acid (ALA), a natural potent antioxidant, has been known as a gastroprotective drug yet its low bioavailability may restrict its therapeutic efficacy. This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the pumpkin oil (X1, 10–30%), the surfactant tween 80 (X2, 20–50%), and the co-surfactant polyethylene glycol 200 (X3, 30–60%). The experimental design for the proposed mixture produced 16 formulations with varying ALA-SNEDDS formulation component percentages. The optimized ALA-SNEDDS formula was investigated for gastric ulcer protective effects by evaluating the ulcer index and by the determination of gastric mucosa oxidative stress parameters. Results revealed that optimized ALA-SNEDDS achieved significant improvement in gastric ulcer index in comparison with raw ALA. Histopathological findings confirmed the protective effect of the formulated optimized ALASNEDDS in comparison with raw ALA. These findings suggest that formulation of ALA in SNEDDS form would be more effective in gastric ulcer protection compared to pure ALA.

Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse

2010 ◽  
Vol 31 (S29) ◽  
pp. 24-29 ◽  
Author(s):  
HELEN M. BERSCHNEIDER ◽  
A. T. BLIKSLAGER ◽  
M. C. ROBERTS
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Disease ◽  
Duodenal Reflux

scholarly journals IMMUNOTHERAPY OF GASTRIC ULCER DISEASE, ASSOCIATED WITH HELIСOBACTER PYLORI USING RECOMBINANT IL-2

2017 ◽  
pp. 122-127
Author(s):  
T. A. Smirnova ◽  
O. V. Borovikov ◽  
E. I. Kleshenko ◽  
M. G. Kulagina ◽  
D. A. Kayumova ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Disease

scholarly journals Treatment of Gastric Candidiasis in Patients with Gastric Ulcer Disease: Are Antifungal Agents Necessary?

Gut and Liver ◽  
2009 ◽  
Vol 3 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Min Kyu Jung ◽  
Seong Woo Jeon ◽  
Chang Min Cho ◽  
Won Young Tak ◽  
Young Oh Kweon ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Antifungal Agents ◽  
Ulcer Disease

Features of the course of peptic ulcer disease in children and adolescents

1985 ◽  
Vol 66 (5) ◽  
pp. 377-377
Author(s):  
N. A. Cherkasova ◽  
H. S. Bikbulatova ◽  
V. N. Leonova
Keyword(s):  
Duodenal Ulcer ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Peptic Ulcer Disease ◽  
Children And Adolescents ◽  
Ulcer Disease

There were 26 patients with gastric ulcer and duodenal ulcer (17 boys, 9 girls) aged from 9 to 18 years under observation.

Additional Antacid Does Not Increase the Effect of Cimetidine in Gastric Ulcer Disease

1984 ◽  
Vol 19 (1) ◽  
pp. 56-58 ◽  
Author(s):  
S. J. Rune ◽  
K. G. Jensen ◽  
H. R. Wulff ◽  
F. Bendtsen ◽  
J. Lindskov ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Disease

Helicobacter pylori infestation in gastric ulcer disease

1994 ◽  
Vol 6 (8) ◽  
pp. 733-738
Author(s):  
Wiktor Laszewicz ◽  
Antoni Gabryelewicz ◽  
Pentti Sipponen ◽  
Max Siurala
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Ulcer Disease
Sign in / Sign up

Export Citation Format

Share Document