Skin Barrier Repair in Atopic Dermatitis Therapy

2014 ◽  
pp. 159-164
Author(s):  
William Abramovits ◽  
Peter Elias
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis

2020 ◽  
Vol 21 (20) ◽  
pp. 7607
Author(s):  
Hai Le Thanh Nguyen ◽  
Juan Valentin Trujillo-Paez ◽  
Yoshie Umehara ◽  
Hainan Yue ◽  
Ge Peng ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Antimicrobial Peptides ◽  
Tight Junction ◽  
Tight Junctions ◽  
Skin Barrier ◽  
Physical Barrier ◽  
Cutaneous Infections ◽  
Barrier Disruption ◽  
Barrier Repair ◽  
Skin Barrier Repair

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are susceptible to cutaneous infections that may progress to complications, including staphylococcal septicemia. Although most studies have focused on filaggrin mutations, the physical barrier and antimicrobial barrier also play critical roles in the pathogenesis of AD. Within the physical barrier, the stratum corneum and tight junctions play the most important roles. The tight junction barrier is involved in the pathogenesis of AD, as structural and functional defects in tight junctions not only disrupt the physical barrier but also contribute to immunological impairments. Furthermore, antimicrobial peptides, such as LL-37, human β-defensins, and S100A7, improve tight junction barrier function. Recent studies elucidating the pathogenesis of AD have led to the development of barrier repair therapy for skin barrier defects in patients with this disease. This review analyzes the association between skin barrier disruption in patients with AD and antimicrobial peptides to determine the effect of these peptides on skin barrier repair and to consider employing antimicrobial peptides in barrier repair strategies as an additional approach for AD management.

scholarly journals Activation of Epidermal Toll-Like Receptor 2 Enhances Tight Junction Function: Implications for Atopic Dermatitis and Skin Barrier Repair

2013 ◽  
Vol 133 (4) ◽  
pp. 988-998 ◽  
Author(s):  
I-Hsin Kuo ◽  
Amanda Carpenter-Mendini ◽  
Takeshi Yoshida ◽  
Laura Y. McGirt ◽  
Andrei I. Ivanov ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Tight Junction ◽  
Skin Barrier ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

2013 ◽  
Author(s):  
Ellen H. van den Bogaard ◽  
Judith G.M. Bergboer ◽  
Mieke Vonk-Bergers ◽  
Ivonne M.J.J. van Vlijmen-Willems ◽  
Stanleyson V. Hato ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Coal Tar ◽  
Skin Barrier ◽  
Barrier Repair ◽  
Skin Barrier Repair

Canadian Consensus on Skin Barrier Repair Therapy in Atopic Dermatitis

2012 ◽  
Vol 16 (1_suppl) ◽  
pp. S1-S15 ◽  
Author(s):  
Richard Thomas ◽  
Ian Landells ◽  
Charles Lynde ◽  
Michelle Withers ◽  
Miriam Weinstein ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Barrier Repair ◽  
Skin Barrier Repair
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