Optimum Biased-Coin Designs with Covariates

2013 ◽  
pp. 175-224
Keyword(s):  
Biased Coin

scholarly journals Exact properties of Efron’s biased coin randomization procedure

2010 ◽  
Vol 38 (3) ◽  
pp. 1546-1567 ◽  
Author(s):  
Tigran Markaryan ◽  
William F. Rosenberger
Keyword(s):  
Biased Coin

ED90 of spinal 2-chloroprocaine 1% in ambulatory knee arthroscopy up to 45 min: a randomized biased-coin- up-and-down sequential allocation trial

2022 ◽  
pp. rapm-2021-103089
Author(s):  
Elsbeth J Wesselink ◽  
Seppe J Koopman ◽  
Rien van der Vegt ◽  
Peter M van de Ven ◽  
Jan P van der Aa ◽  
...  
Keyword(s):  
Hospital Discharge ◽  
Knee Arthroscopy ◽  
Final Analysis ◽  
Sensory Block ◽  
Complete Recovery ◽  
Open Label ◽  
Urine Retention ◽  
Quick Recovery ◽  
Smooth Flow ◽  
Biased Coin

BackgroundA short acting spinal anesthetic facilitates smooth flow since quick recovery of motor function will facilitate unassisted ambulation. The aim of this study was to estimate the effective dose (ED90) of intrathecal 2-chloroprocaine 1% in outpatient knee arthroscopy.MethodsTwo cohorts were included in two different hospitals. In cohort I, a randomized biased-coin up-and-down design with 40 patients was used to find the ED90. Four dose-levels of plain 2-chloroprocaine 1% were used: 25, 30, 35 and 40 mg. The identified primary outcome, the ED90, was validated in 50 patients in cohort II with an open label design. Secondary outcomes included time to complete recovery from motor and sensory block with spinal injection as time zero, peak sensory block level, urine retention and time until hospital discharge.ResultsForty patients were included in the final analysis in cohort I. The ED90 was estimated at 27.8 mg, successful spinal anesthesia was obtained in 38 patients (95%). Fifty patients were included in the final analysis in cohort II, 49 patients had successful anesthesia with a fixed round dose of 28 mg. In this Cohort, peak sensory block was T10/T11 (range: (L4–T4)). The median time to full recovery of the motor block was 60 min (45–60) and 90 min (75–105) for the sensory block. The mean time to hospital discharge was 2.9 hours (0.7).ConclusionThe ED90 of 2-chloroprocaine 1% in knee arthroscopy was estimated to be 27.8 mg. In an external population, the ED90 resulted in successful anesthesia in 98% of the patients (95% CI 89% to 100%).Trial registration numberNetherlands Trial Registry (NL6769).

scholarly journals Robust quantum state engineering through coherent localization in biased-coin quantum walks

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Helena Majury ◽  
Joelle Boutari ◽  
Elizabeth O’Sullivan ◽  
Alessandro Ferraro ◽  
Mauro Paternostro
Keyword(s):  
Quantum State ◽  
Quantum Walks ◽  
Quantum State Engineering ◽  
Biased Coin

scholarly journals On the modified Palm version

2018 ◽  
Vol 50 (A) ◽  
pp. 271-280
Author(s):  
Hermann Thorisson
Keyword(s):  
Limit Theorem ◽  
Abelian Groups ◽  
Random Measure ◽  
Random Measures ◽  
Locally Compact ◽  
Standard Version ◽  
Biased Coin

Abstract The interpretation of the ‘standard’ Palm version of a stationary random measure ξ is that it behaves like ξ conditioned on containing the origin in its mass. The interpretation of the ‘modified’ Palm version is that it behaves like ξ seen from a typical location in its mass. In this paper we shall focus on the modified Palm version, comparing it with the standard version in the transparent case of mixed biased coin tosses, and then establishing a limit theorem that motivates the above interpretation in the case of random measures on locally compact second countable Abelian groups possessing Følner averaging sets.

scholarly journals Natural Biased Coin Encoded in the Genome Determines Cell Strategy

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103569 ◽  
Author(s):  
Faezeh Dorri ◽  
Hamid Mahini ◽  
Ali Sharifi-Zarchi ◽  
Mehdi Totonchi ◽  
Ruzbeh Tusserkani ◽  
...  
Keyword(s):  
Biased Coin
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