Optimum Biased-Coin Designs with Covariates

Keyword(s):  
2010 ◽  
Vol 38 (3) ◽  
pp. 1546-1567 ◽  
Author(s):  
Tigran Markaryan ◽  
William F. Rosenberger
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2022 ◽  
pp. rapm-2021-103089
Author(s):  
Elsbeth J Wesselink ◽  
Seppe J Koopman ◽  
Rien van der Vegt ◽  
Peter M van de Ven ◽  
Jan P van der Aa ◽  
...  

BackgroundA short acting spinal anesthetic facilitates smooth flow since quick recovery of motor function will facilitate unassisted ambulation. The aim of this study was to estimate the effective dose (ED90) of intrathecal 2-chloroprocaine 1% in outpatient knee arthroscopy.MethodsTwo cohorts were included in two different hospitals. In cohort I, a randomized biased-coin up-and-down design with 40 patients was used to find the ED90. Four dose-levels of plain 2-chloroprocaine 1% were used: 25, 30, 35 and 40 mg. The identified primary outcome, the ED90, was validated in 50 patients in cohort II with an open label design. Secondary outcomes included time to complete recovery from motor and sensory block with spinal injection as time zero, peak sensory block level, urine retention and time until hospital discharge.ResultsForty patients were included in the final analysis in cohort I. The ED90 was estimated at 27.8 mg, successful spinal anesthesia was obtained in 38 patients (95%). Fifty patients were included in the final analysis in cohort II, 49 patients had successful anesthesia with a fixed round dose of 28 mg. In this Cohort, peak sensory block was T10/T11 (range: (L4–T4)). The median time to full recovery of the motor block was 60 min (45–60) and 90 min (75–105) for the sensory block. The mean time to hospital discharge was 2.9 hours (0.7).ConclusionThe ED90 of 2-chloroprocaine 1% in knee arthroscopy was estimated to be 27.8 mg. In an external population, the ED90 resulted in successful anesthesia in 98% of the patients (95% CI 89% to 100%).Trial registration numberNetherlands Trial Registry (NL6769).


2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Helena Majury ◽  
Joelle Boutari ◽  
Elizabeth O’Sullivan ◽  
Alessandro Ferraro ◽  
Mauro Paternostro

2018 ◽  
Vol 50 (A) ◽  
pp. 271-280
Author(s):  
Hermann Thorisson

Abstract The interpretation of the ‘standard’ Palm version of a stationary random measure ξ is that it behaves like ξ conditioned on containing the origin in its mass. The interpretation of the ‘modified’ Palm version is that it behaves like ξ seen from a typical location in its mass. In this paper we shall focus on the modified Palm version, comparing it with the standard version in the transparent case of mixed biased coin tosses, and then establishing a limit theorem that motivates the above interpretation in the case of random measures on locally compact second countable Abelian groups possessing Følner averaging sets.


PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103569 ◽  
Author(s):  
Faezeh Dorri ◽  
Hamid Mahini ◽  
Ali Sharifi-Zarchi ◽  
Mehdi Totonchi ◽  
Ruzbeh Tusserkani ◽  
...  
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