Bayesian Approach to QTL Mapping

2016 ◽  
pp. 205-238
Keyword(s):  
Qtl Mapping ◽  
Bayesian Approach

A new Bayesian approach for QTL mapping of family data

2021 ◽  
Author(s):  
Daiane Aparecida Zuanetti ◽  
Luis Aparecido Milan
Keyword(s):  
Qtl Mapping ◽  
Random Effects ◽  
Bayesian Approach ◽  
Variance Component ◽  
Mendelian Inheritance ◽  
Family Data ◽  
Data Sets ◽  
Mendelian Segregation ◽  
Gaw17 Data ◽  
The Bayesian Approach

In this paper, we propose a new Bayesian approach for QTL mapping of family data. The main purpose is to model a phenotype as a function of QTLs’ effects. The model considers the detailed familiar dependence and it does not rely on random effects. It combines the probability for Mendelian inheritance of parents’ genotype and the correlation between flanking markers and QTLs. This is an advance when compared with models which use only Mendelian segregation or only the correlation between markers and QTLs to estimate transmission probabilities. We use the Bayesian approach to estimate the number of QTLs, their location and the additive and dominance effects. We compare the performance of the proposed method with variance component and LASSO models using simulated and GAW17 data sets. Under tested conditions, the proposed method outperforms other methods in aspects such as estimating the number of QTLs, the accuracy of the QTLs’ position and the estimate of their effects. The results of the application of the proposed method to data sets exceeded all of our expectations.

Verbal statistical learning: Prior knowledge impacts word identification but not metacognition

2020 ◽  
Author(s):  
Laetitia Zmuda ◽  
Charlotte Baey ◽  
Paolo Mairano ◽  
Anahita Basirat
Keyword(s):  
Task Performance ◽  
Prior Knowledge ◽  
Statistical Learning ◽  
Cognitive Processes ◽  
Bayesian Approach ◽  
Word Identification ◽  
Artificial Language ◽  
Artificial Languages ◽  
Transitional Probabilities ◽  
Fully Bayesian

It is well-known that individuals can identify novel words in a stream of an artificial language using statistical dependencies. While underlying computations are thought to be similar from one stream to another (e.g. transitional probabilities between syllables), performance are not similar. According to the “linguistic entrenchment” hypothesis, this would be due to the fact that individuals have some prior knowledge regarding co-occurrences of elements in speech which intervene during verbal statistical learning. The focus of previous studies was on task performance. The goal of the current study is to examine the extent to which prior knowledge impacts metacognition (i.e. ability to evaluate one’s own cognitive processes). Participants were exposed to two different artificial languages. Using a fully Bayesian approach, we estimated an unbiased measure of metacognitive efficiency and compared the two languages in terms of task performance and metacognition. While task performance was higher in one of the languages, the metacognitive efficiency was similar in both languages. In addition, a model assuming no correlation between the two languages better accounted for our results compared to a model where correlations were introduced. We discuss the implications of our findings regarding the computations which underlie the interaction between input and prior knowledge during verbal statistical learning.

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